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Patent # Description
US-9,365,592 Bonding composition
To provide a bonding composition where high joint strength can be obtained due to joining at a comparatively low temperature and under a pressureless condition,...
US-9,365,591 Fluoroergoline analogs
Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or...
US-9,365,590 Selenophene-fused aromatic compound and manufacturing method thereof
The present disclosure relates to a method for more easily and economically producing a selenophene-fused aromatic compound derivative containing various...
US-9,365,589 C5, C6 oxacyclic-fused thiazine dioxide compounds as BACE inhibitors, compositions, and their use
In its many embodiments, the present invention provides certain C2-ring-substituted iminothiazine compounds, including compounds Formula (I): (structurally...
US-9,365,588 Benzoxazines as modulators of ion channels
The invention relates to benzoxazines useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the...
US-9,365,587 Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
The invention is a process for the preparation of a compound of the following formula (I): ##STR00001## wherein R is --CHO, --CH(OH).sub.2 or...
US-9,365,586 Method for producing dithiine tetracarboximides
The present invention relates to a process for preparing dithiinetetracarboximides by reaction of succinic monoamides with thionyl chloride, with continuous...
US-9,365,585 Semiconducting polymers
The invention relates to novel polymers containing repeating units based on benzodithiophene or derivatives thereof, monomers and methods for their preparation,...
US-9,365,584 Thieno [2,3-B] pyridinedione activators of AMPK and therapeutic uses thereof
The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by...
US-9,365,583 Substituted pyrazoles and uses thereof
The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various...
US-9,365,582 Macrocyclic inhibitors of hepatitis C virus
Inhibitors of HCV replication of formula (I) ##STR00001## and the salts and stereoisomers thereof, wherein each dashed line (represented by - - - - -)...
US-9,365,581 Deuterated amlexanox
Provided herein is technology relating to deuterated amiexanox and particularly, but not exclusively, to compositions comprising deuterated amiexanox, methods...
US-9,365,580 Polymorphic forms of naltrexone
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and...
US-9,365,579 Tricyclic compounds
The invention provide a compound of Formula (I) ##STR00001## pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomer and...
US-9,365,578 Biaryl ether sulfonamides and their use as therapeutic agents
This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention...
US-9,365,577 Pyrimidinone compounds as human neutrophil elastase inhibitors
Pyrimidinone compounds defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HINE...
US-9,365,576 Pyrrolopyrrolidinone compounds
The invention relates to compounds of formula (I): ##STR00001## as described herein, pharmaceutical preparations comprising such compounds, uses and methods...
US-9,365,575 Kinase inhibitors
The present invention relates to compounds of Formula I ##STR00001## or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar.sup.1...
US-9,365,574 Soluble guanylate cyclase activators
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate...
US-9,365,573 Method for synthesizing sapropterin dihydrochloride
Disclosed is a method for synthesizing sapropterin dihydrochloride. The present disclosure reduces a synthesis route of the sapropterin dihydrochloride,...
US-9,365,572 PI3K and/or mTOR inhibitor
The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, a stereoisomer or a solvate thereof, wherein R.sup.1,...
US-9,365,571 Piperidino-pyrimidine derivatives for the treatment of viral infections
This invention relates to piperidino-pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral...
US-9,365,570 Substituted 6, 5-fused bicyclic heteroaryl compounds
The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these...
US-9,365,569 Antagonists acting at multiple prostaglandin receptors for the treatment of inflammation
Compounds, processes for their preparation, pharmaceutical compositions containing such compounds and their use in treating therapeutic conditions, in...
US-9,365,568 Pyrrolopyridines as kinase inhibitors
Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable...
US-9,365,567 Alkoxy substituted imidazoquinolines
Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates,...
US-9,365,566 Cinnoline derivatives
Disclosed are compounds of Formula 1, ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are...
US-9,365,565 Salts of aza-bicyclic di-aryl ethers and pharmaceuticals thereof
The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors,...
US-9,365,564 3,3-disubstituted-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1H-pyrazol-4-yl)-thio- phen-3-yl]-methanones as inhibitors...
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
US-9,365,563 TRPV1 antagonists including dihydroxy substituent and uses thereof
The invention relates to compounds of formula IA ##STR00001## and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount...
US-9,365,562 1,3 substituted azetidine PDE10 inhibitors
The present invention is directed to substituted azetidine compounds which are useful as therapeutic agents for the treatment of central nervous system...
US-9,365,561 C5 benzothiazolyl sulfone compound, method of preparing preparing the same, method of preparing polyene...
Disclosed are a novel C5 benzothiazolyl sulfone compound having an acetal protecting group, a method of preparing the same, and a method of efficiently...
US-9,365,559 Crystal form of Dabrafenib and preparation method of use thereof
The invention relates to Crystal Hydrate Form VI of Dabrafenib and preparation method thereof, wherein Crystal Hydrate Form VI of Dabrafenib has the advantage...
US-9,365,558 Dihydropyridinone MGAT2 inhibitors
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the...
US-9,365,557 Substituted pyrazin-2-amines as inhibitors of ATR kinase
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable...
US-9,365,556 3,5-diaminopyrazole kinase inhibitors
Provided herein are 3,5-diaminopyrazoles, for example, compounds of Formula IA, that are useful for modulating regulated-in-COPD kinase activity, and...
US-9,365,555 PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
US-9,365,554 Viral polymerase inhibitors
The present invention relates to viral polymerase inhibitors of formula (I) or salts, N-oxides, solvates, hydrates, racemates, enantiomers or isomers thereof,...
US-9,365,553 Heterocyclic compound and H1 receptor antagonist
A heterocyclic compound useful as an antiallergic agent is provided. A compound represented by the following formula (1) or a salt thereof: ##STR00001## ...
US-9,365,552 Pyridine and pyrazine derivative for the treatment of CF
The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis,...
US-9,365,551 2-(benzyloxy) benzamides as LRRK2 kinase inhibitors
The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to...
US-9,365,550 Benzimidazoles as CNS active agents
The present invention relates to compounds of general formula ##STR00001## wherein R.sup.1 hydrogen, lower alkyl, halogen or lower alkyl substituted by...
US-9,365,549 Hepatitis C virus inhibitors
The invention provides compounds of formulas (I) or (II): ##STR00001## wherein the variables are defined in the specification, or a pharmaceutically-acceptable...
US-9,365,548 Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor
Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by...
US-9,365,547 Substituted pyridinone-pyridinyl compounds
The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory...
US-9,365,546 Substituted pyridinone-pyridinyl compounds
The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory...
US-9,365,545 Therapeutic compounds and compositions
Compounds of general formula I: ##STR00001## and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein....
US-9,365,544 Process for the preparation of intermediates for the synthesis of Dabigatran Etexilate, and crystalline forms...
The present invention relates to new processes for the preparation of synthesis intermediate products useful in the preparation of Dabigatran Etexilate on an...
US-9,365,543 N-Thio-anthranilamid compounds and their use as pesticides
N-Thio-anthranilamid compounds of formula (I) ##STR00001## wherein A is A.sup.1 ##STR00002## wherein the variables and the indices are as defined per the...
US-9,365,542 Modulators of resistant androgen receptor
The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making...
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