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Pentamethylenediisocyanate, method for producing
pentamethylenediisocyanate, polyisocyanate composition,...
A Pentamethylene diisocyanate is obtained by phosgenating pentamethylenediamine or its salt obtained by a biochemical method, and contains 5 to 400 ppm of a...
Process for imparting grease, oil and water repellence to substrates
A process for imparting grease, oil and water repellence to a substrate comprises applying by means of a printing process on at least a portion of the surface...
Abrasion-resistant and alkali-resistant coatings or moulded bodies having
a low-energy surface
The invention relates to a composition for producing abrasion-resistant and alkali-resistant layers or molded bodies having a low-energy surface, said...
Polyurethane elastomers for use in subsea pipeline insulation
Polyurethane systems that cure similarly to systems based on mercury catalysts contain 1,4-butanediol and a zinc carboxylate catalyst. These systems cure and...
Curing compositions having low-free amounts of methylenedianiline
A process for preparing a curing composition of a coordination complex comprising methylenedianiline (MDA) and a salt, and less than 1000 of free MDA. The...
Polymer and method for using the same
The invention relates to a polymer derived from: reaction of glycidyl (meth)acrylate, allyl glycidyl ether or [(vinyloxy)methyl]oxirane with ammonia or primary...
Catalyst system with three metallocenes for producing broad molecular
weight distribution polymers
Disclosed herein are polymerization processes for the production of olefin polymers. These polymerization processes use a catalyst system containing three...
Apparatus and process for making high-pressure polyethylene polymers and
Embodiments of the invention provide an apparatus for the manufacture of polyethylene and polyethylene copolymers. The apparatus includes a primary compressor...
Nucleation in aqueous polymerization of fluoromonomer
A process is provided for polymerizing fluoromonomer in an aqueous medium, wherein a dispersion of essentially surfactant-free hydrocarbon-containing oleophilic...
System and method for rapid transitioning of polyolefin processes from one
product to another
A gas-phase polyolefin reactor system for rapidly transitioning from one polyolefin product to another is disclosed. The reactor system comprises a control...
Hydrogenation of diene-based polymers
This invention relates to a process for the hydrogenation of diene-based copolymers in the presence of catalysts on specific carrier materials containing at...
Method for producing cross-linked hyaluronic acid
A method for producing a cross-linked hyaluronic acid in accordance with the present invention comprises: (a) cross-linking at least one polymer at a...
Low energy method for the preparation of non-derivatized nanocellulose
A low energy method for the preparation of nanocellulose using selected organic or inorganic swelling agents. The use of these swelling agents allows opening up...
Thermal regulating building materials and other construction components
containing phase change materials
A material for energy management and peak energy reduction in a building structure, comprises an insulative base material, a first phase change material, and a...
Methods for producing alkali cellulose and cellulose ether
A degree of polymerization of cellulose ether is accurately controlled, and quality and a manufacturing process of the cellulose ether are stabilized. There is...
Methods for preparing alkali cellulose and cellulose ether
Provided is a method for efficiently preparing alkali cellulose having a uniform alkali distribution. More specifically, provided are a methods for preparing...
The present application relates to CTLA4-Ig immunoadhesins that target CD80 and CD86, and their use, particularly for therapeutic purposes.
Anti-CD22 anti-idiotypic antibodies and uses thereof
The present invention describes the generation of an anti-idiotype single-chain Fv (scFv) antibody specific for the murine (RFB4), chimeric (SM03) and humanized...
Anti B7-H3 antibody
An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or...
Monoclonal antibodies and detection methods for
Described herein are monoclonal antibodies and methods useful for determining and quantitating the presence of a phosphinothricin-N-acetyl-transferase enzyme....
Class I anti-CEA antibodies and uses thereof
The present invention provides compositions and methods of use of humanized, chimeric or human Class I anti-CEA antibodies or fragments thereof, preferably...
Treatment of complex regional pain syndrome using denosumab
Disclosed herein are methods of treating pain using comprising RANK/RANKL antagonists.
Anti-human IL-23 receptor antibody and encoding polynucleotides
[Problem] An object of the present invention is to provide an anti-human IL-23R antibody having excellent activity and/or cross-reactivity compared to...
Cytokine receptors associated with myelogenous haematological
proliferative disorders and uses thereof
The disclosure relates to methods and compositions effective in the diagnosis, prognosis and treatment of human hematopoietic cancers. In particular, the...
Anti-human XCR1 antibodies
An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes...
High affinity antibody antagonists of interleukin-13 receptor alpha 1
High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of...
Composition for prevention or treatment of ischemic cardiac disease,
comprising inhibitor against age-albumin...
Disclosed is a pharmaceutical composition for the prevention or treatment of ischemic heart diseases, comprising as an active ingredient an inhibitor which acts...
Methods and compositions for bi-specific targeting of CD19/CD22
Methods and composition involving genetically engineered targeting conjugates with reversed orientation of VL and VH chains are provided. For example, in...
Compositions and methods for diagnosing and treating an inflammation
A method of treating a graft rejection disease in a subject in need thereof, the method comprising administering to said subject a therapeutically effective...
Anti-ASIC1 antibodies and uses thereof
The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1)....
Polyclonal-monoclonal ELISA assay for detecting N-terminus pro-BNP
A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids,...
Single domain antibodies directed against tumor necrosis factor-alpha and
The present invention relates to polypeptides derived from single domain heavy chain antibodies directed to Tumor Necrosis Factor-alpha. It further relates to...
Antitumor agent and therapeutic effect prediction method for patients with
KRAS-mutated colorectal cancer
This invention provides a method for predicting a therapeutic effect of chemotherapy that uses an antitumor agent comprising ...
Methods for treating malaria by administering an antibody that
specifically binds angiopoietin-2 (ang-2)
The present invention provides methods for treating malaria by administering to a patient in need thereof a pharmaceutical composition comprising an antibody...
The present disclosure relates to, inter alia, antibodies, or antigen-binding fragments thereof, that bind to C5a and to use of the antibodies in methods for...
Anti-C5 antibodies having improved pharmacokinetics
The disclosure provides antibodies that are useful for, among other things, inhibiting terminal complement (e.g., the assembly and/or activity of the C5b-9 TCC)...
Anti-PHF-tau antibodies and their uses
Anti-PHF-tau antibodies and methods of making and using them are disclosed.
Recombinant monoclonal antibodies and corresponding antigens for colon and
The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with...
HCV core lipid binding domain monoclonal antibodies
The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core...
Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric
domain, immunisation method,...
Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric domain, immunization method, and treatment method for rotavirus infections, wherein said...
Human cytomegalovirus neutralizing antibodies and use thereof
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody...
Engineering of immunoglobulin domains
The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide bond in the framework region...
Coagulation factor VII polypeptides
The present invention relates to modified coagulation Factor VII polypeptides exhibiting increased resistance to antithrombin inactivation and enhanced...
Extended recombinant polypeptides and compositions comprising same
The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids...
Compositions and methods for immunomodulation in an organism
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need...
Selective delivery molecules and methods of use
Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells...
Influenza virus vaccines and uses thereof
Provided herein are chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use.
Modified compstatin with peptide backbone and C-terminal modifications
Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved...
Dual-targeted therapeutic peptide for nasopharyngeal carcinoma,
nanoparticles carrying same and uses thereof
Disclosed is a dual-targeted therapeutic peptide for nasopharyngeal carcinoma formed by covalently linking a targeted therapeutic peptide for nasopharyngeal...
Peptides and their use
The invention relates to peptides, and peptide variants thereof, in which substantially all of the amino acids in the amino sequence of said peptide are the...