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Patent # Description
US-9,371,362 Prostate specific antigen agents and methods of using same for prostate cancer imaging
The invention provides a family of agents that target the prostate specific antigen, which can be used as imaging agents or therapeutic agents. The agents can...
US-9,371,361 Method of producing FR901228
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including...
US-9,371,360 Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (PSMA) and uses thereof
The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of PSMA...
US-9,371,359 Lissencephaly therapeutic agent
An object of the present invention is to provide a medicament and method for treating lissencephaly patients. The present invention provides a lissencephaly...
US-9,371,358 Tubulysin analogues
The present invention relates to novel tubulysin compounds (tubulysin analogs) as well as pharmaceutical formulations thereof. The present invention further...
US-9,371,357 Inhibitors of viral integrase and methods of use
Described herein are compositions and methods for inhibiting HIV integrase activity. Also described are methods of identifying agents that inhibit HIV integrase...
US-9,371,356 Separation of biocomponents from manure
A process for separating amino acids and peptides from raw and digested farm manure is disclosed. The raw manure may be recovered from sand bedding used in the...
US-9,371,355 Process for production of fibrinogen
The present invention relates to a method or process for the manufacture of a virus and prion save native fibrinogen concentrate of high purity and low amounts...
US-9,371,354 DNA-linked nanoparticle building blocks for nanostructure assembly and methods of producing the same
A method of producing a nanoparticle assembly. The method includes attaching a first DNA molecule to a bead to form a first DNA-bead complex; and combining a...
US-9,371,353 Oligonucleotide with protected base
The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction...
US-9,371,352 Modified glycolipids and methods of making and using the same
The invention is directed to compositions and methods related to proteins that are physically associated with ceramide-like glycolipids for use as activators of...
US-9,371,351 Glycomimetics as Pseudomonas aeruginosa lectin inhibitors
The present invention relates to fucose- and mannose-derived glycomimetics and their general use in prophylaxis or treatment of Pseudomonas aeruginosa...
US-9,371,350 Trehalose derivatives and pharmaceutical compositions for treating neurodegenerative diseases
The invented inositol and trehalose derivatives, prepared by introducing multiple units of the guanidine group to the backbone molecules, show excellent...
US-9,371,349 Low temperature, vacuum assisted chlorination of sucrose-6-esters free of overchlorinated by-products as...
Disclosed is a method of chlorinating a carbohydrate or derivative thereof, for example, a sucrose-6-ester at the 4,1', and 6' positions, with irreversible...
US-9,371,348 Photocleavable oligonucleotide and uses thereof
This invention relates to methods and compositions of oligonucleotide constructs having a photocleavable linker. Specifically, provided herein are methods and...
US-9,371,347 dppf-like compounds and method of manufacture and use
A method of .beta.-hydride elimination and subsequent 2,1-insertion from a transient nickel(II) acrylate hydride intermediate (Structure I). ##STR00001## Also...
US-9,371,346 Preparing a nickel phosphorus ligand complex
The present invention relates to a method of preparing a nickel complex including nickel and at least one phosphorus-containing ligand by reacting at least a...
US-9,371,345 Metathesis catalysts containing onium groups
Disclosed herein is a general method for the preparation of complexes containing a quaternary onium group in an inert ligand. Some of these complexes may be...
US-9,371,344 Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of...
US-9,371,343 Nickel metal compositions and nickel complexes derived from basic nickel carbonates
Nickel-metal-containing solids for use in manufacturing nickel metal complexes are disclosed. The nickel-metal-containing solids are made by reducing basic...
US-9,371,342 Isoprene oligomer, polyisoprene, processes for producing these materials, rubber composition, and pneumatic tire
The invention relates to an isoprene oligomer that contains a trans structural moiety and a cis structural moiety, which can be represented by the following...
US-9,371,341 Cyclic aminoorganoxysilane compound and its production method
A method for producing a cyclic aminoorganoxysilane compound is provided. The method comprises the step of conducting dehydrochlorination coupling of a...
US-9,371,340 Dehydrogenative silylation, hydrosilylation and crosslinking using cobalt catalysts
Disclosed herein are cobalt complexes containing terdentate pyridine di-imine ligands and their use as efficient and selective dehydrogenative silylation,...
US-9,371,339 Saturated and unsaturated silahydrocarbons via iron and cobalt pyridine diimine catalyzed olefin silylation
The present invention relates to processes for the synthesis of saturated and unsaturated silahydrocarbons using iron-containing or cobalt-containing catalysts....
US-9,371,338 Organosilane precursors for ALD/CVD silicon-containing film applications
Disclosed are Si-containing thin film forming precursors, methods of synthesizing the same, and methods of using the same to deposit silicon-containing films...
US-9,371,337 .beta.-lactamase inhibitors
Disclosed herein inter alia are Boron containing compounds and methods for treating infections related to antibiotic resistant microorganisms.
US-9,371,336 Compounds for treating spinal muscular atrophy
Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
US-9,371,335 Spirothienopyran-piperidine derivatives as ORL-1 receptor antagonists for their use in the treatment of alcohol...
The use of ORL-1 receptor antagonists of the formula: ##STR00001## for the treatment of alcohol use disorders is described.
US-9,371,334 Synthesis of substituted salicylaldehyde derivatives
Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde...
US-9,371,333 Chromene derivatives and their analoga as Wnt pathway antagonists
Compounds of formula (IIc); wherein X.sup.3 and X.sup.4 independently from each other are N or CR.sup.8 wherein R.sup.8 may be same or different; Y.sup.1,...
US-9,371,332 Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with...
Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic...
US-9,371,331 Modulators of methyl modifying enzymes, compositions and uses thereof
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
US-9,371,330 Substituted pyrazino[1,2-a]pyrimidines useful as CBP/catenin antagonists for enhancing asymmetric division of...
Provided are: composition and methods for: treating aging or an age-related condition, symptom or disease; stimulating hair growth, regrowth or pigmentation (or...
US-9,371,329 Fused heterocyclic compounds as ion channel modulators
The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including...
US-9,371,328 Imidazopyridazinecarbonitriles useful as kinase inhibitors
The invention provides compounds of Formula (I) ##STR00001## and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein...
US-9,371,327 PDE1 inhibitor compounds
The present invention relates to optionally substituted (5- or 7-oxy)-3,4-dihydro-(optionally 4-oxo, 4-thioxo or ...
US-9,371,326 Method for synthesizing sapropterin dihydrochloride
Disclosed is a method for synthesizing sapropterin dihydrochloride. The present disclosure reduces a synthesis route of the sapropterin dihydrochloride, and...
US-9,371,325 Purinone derivative hydrochloride
The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-di- hydro-8H-purin-8-one hydrochloride has Btk-selective...
US-9,371,324 Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
The invention relates to particular substituted heterocycle fused gamma-carbolines, of Formula I as described herein, their prodrugs, in free, solid,...
US-9,371,323 Spirocycles as inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1
The present invention relates to certain spirocyclic compounds that are inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1 (11.beta.HSD1),...
US-9,371,322 Bicyclic aza-amides for treatment of psychiatric disorders
The present invention relates to compounds of formula (I) having a bicyclic aza-amides scaffold, pharmaceutically acceptable salts of these compounds and...
US-9,371,321 Azaindole derivatives
Disclosed are compounds of Formula 1, ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5,...
US-9,371,320 Heterocyclic compound
The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune...
US-9,371,319 Pyrrolopyridineamino derivatives as MPS1 inhibitors
The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as "PPA derivatives"), particularly ...
US-9,371,318 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
Compounds of formula (I) described herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention...
US-9,371,317 Sweet flavor modifier
The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The...
US-9,371,316 Pyridine derivatives
The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing...
US-9,371,315 N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamide salts and use thereof as herbicides
Salts of N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of the general formula (I) are described as herbicides. ##STR00001## In this formula (I), W,...
US-9,371,314 Pyridyl benzothiophenes as kinase inhibitors
This invention is directed to compounds, which are useful as protein kinase (PK) inhibitors and can be used to treat such diseases as cancer, blood vessel...
US-9,371,313 Process for extracting compound from cranberry leaves and related products
Provided are methods of producing proanthocyanidin (PAC)-containing solutions, powders, and beverages, as are PAC-containing solutions, powders, and beverages...
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