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Patent # Description
US-9,371,312 Crystalline solids of a MetAP-2 inhibitor and methods of making and using same
The disclosure is in part directed to crystalline forms of 6-O-(4-dimethylaminoethoxy)cinnamoyl fumagillol and variants thereof.
US-9,371,311 Benzoimidazol-2-yl pyrimidine derivatives
The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H.sub.4 receptor modulators and processes for the preparation...
US-9,371,310 Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by coupling 3-bromopyridine with commercially available 3-aminopyrazole, purifying the...
US-9,371,309 Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of...
US-9,371,308 Polymeric photoinitiators
A polymeric photoinitiator, most suitably a polyurethane photoinitiator, is obtained by step-growth co-polymerization of at least one monomer (A) with at least...
US-9,371,307 Serine protease inhibitors
Potent low molecular weight, highly selective, competitive non-peptidic serine protease inhibitors and their use in treating serine protease-associated diseases...
US-9,371,306 Cyclic (poly)glycerol sulphates and preparation and use thereof
The present invention relates to novel cyclic sulphates of (poly)glycerol, particularly to the novel compound of ...
US-9,371,305 Deuterated benzopyran compounds and application thereof
The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or...
US-9,371,304 Compound separated from monascus-fermented rice,the preparation method and uses thereof
The present invention discloses a compound separated from Monascus-fermented rice, the preparation method and uses thereof. Specifically, the present invention...
US-9,371,303 Diphenylmethane derivatives as SGLT2 inhibitors
A compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine...
US-9,371,302 Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer
Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention...
US-9,371,301 Prenylarene compound and use thereof
A compound represented by the general formula (C): ##STR00001## (wherein R.sup.101 represents a substituted or unsubstituted aromatic heterocyclic group,...
US-9,371,300 Catalytic epoxidation process
Methods and compositions are provided for the manufacture of an epoxide. In one embodiment, the invention provides a process for the manufacture of an epoxide...
US-9,371,299 Thiadiazolidinediones as GSK-3 inhibitors
The present invention relates to new thiadiazolidinediones of formula (I), or any pharmaceutically acceptable salt, solvate or prodrug thereof, and its use in...
US-9,371,298 Processes for the preparation of isothiazole derivatives
Processes and intermediates for the preparation of compounds of the Formula I ##STR00001## and the pharmaceutically acceptable salts, prodrugs, solvates and...
US-9,371,297 Macrocyclic ghrelin receptor modulators and methods of using the same
The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth...
US-9,371,296 Bicyclic 1,3,4-oxadiazole derivatives as sphingosine-1-phosphate receptors' modulators
The present invention relates to bicyclic 1,3,4-oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use...
US-9,371,295 Compounds for use in the treatment of disorders that are ameliorated by inhibition of HDAC
The present invention relates to compounds of formula (I) and (IV), and pharmaceutically acceptable salts, tautomers, stereoisomers thereof, which are...
US-9,371,294 Cycloalkenyl aryl derivatives for CETP inhibitor
The present invention relates to cycloalkenyl aryl derivatives, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof, or solvates...
US-9,371,293 Isoxazoline compound composition
The present invention relates to a composition comprising an isoxazoline compound, the isoxazoline compound being dispersed in a solid vehicle of one or more...
US-9,371,292 Quinazoline derivative, preparation method therefor, intermediate, composition and application thereof
Disclosed are as represented by Formula (I) a quinazoline derivative and a pharmaceutical acceptable salt thereof, or, an enantiomer, a non-enantiomer, a...
US-9,371,291 Process for the manufacture of the calcium salt of rosuvastatin ...
A process for the manufacture of the calcium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyri- ...
US-9,371,290 Pyridazinone compounds
The invention relates to pyridazinone and pyridone compounds having formula (I) or (I'), and pharmaceutically acceptable salts, hydrates, and solvates thereof...
US-9,371,289 Phenoxyethyl dihydro-1H-isoquinoline compounds
The present invention provides a compound of the Formula I: wherein R is H or F; or a pharmaceutically acceptable salt thereof. ##STR00001##
US-9,371,288 Crystalline forms of a prolyl hydroxylase inhibitor
The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of...
US-9,371,287 Process for making modulators of cystic fibrosis transmembrane conductance regulator
The invention provides a process for the preparation of a compound of Formula 1, ##STR00001## comprising coupling a carboxylic acid of Formula 2 ##STR00002##...
US-9,371,286 Pharmaceutical composition with enhanced efficacy for inhibiting angiogenesis
The present invention relates to a pharmaceutical composition for inhibiting angiogenesis and a novel sulfonyl amide derivative compound which can be useful for...
US-9,371,285 Insulin secretion promoting agents
The present disclosure relates to novel compounds, compositions containing same and methods for treating or preventing a condition associated with a deficient...
US-9,371,284 Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses
The novel positively charged pro-drugs of NSAIAs in the general formulas (1, 2a, 2b, 2c, or 2d) "Structure 1, 2a, 2b, 2c, or 2d" were designed and synthesized....
US-9,371,283 Polycyclic tetracycline compounds
The present invention is directed to a compound represented by Structural Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. The...
US-9,371,282 Somatostatin receptor subtype 4 (SSTR4) agonists
3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating...
US-9,371,281 Indole derivatives as inhibitors of histone deacetylase
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also...
US-9,371,280 Substituted pyrrolidine-2-carboxamides
There are provided compounds of the formula ##STR00001## wherein X, Y, Z, R.sub.1, R.sub.2 and R.sub.3 are as described herein and enantiomers and...
US-9,371,279 Transesterification process of retinol esters
The present invention relates to a transesterification process of specific compounds comprising isoprenoid units.
US-9,371,278 Sulfur derivatives as chemokine receptor modulators
The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as...
US-9,371,277 Benzamide compounds and related methods of use
Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's...
US-9,371,276 Compositions and methods for the treatment of hyperglycemia and metabolic syndrome
The invention relates to the compounds and compositions of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI or its pharmaceutical...
US-9,371,275 5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis
There is provided a compound of Formula (I) ##STR00001## and salts thereof, where R.sub.1 is an oxime or an alkylated oxime; the alkylated oxime comprises a...
US-9,371,274 Compound having read-through activity
[Problem] Provision of a novel compound having read-through activity and a drug for the treatment of nonsense mutation-type disease containing this compound....
US-9,371,273 Ether-amide compounds and preparation and uses thereof
Ether-amide compounds having the formula R.sup.aR.sup.bC(OR.sup.1)--CHR.sup.c--CONR.sup.2R.sup.3 are described. Also described, are processes for the...
US-9,371,272 Method for producing hydrogen or heavy hydrogens, method for producing hydrogenated (protiated, deuterated or...
Objects are to provide efficient methods for producing hydrogen or heavy hydrogens and for hydrogenating (protiating, deuterating or tritiating) an organic...
US-9,371,271 Method for manufacturing tertiary amino group-containing lipid
In production of a cationic lipid having at least one methylene group sandwiched between adjacent two cis form double bonds in the molecule, isomerization from...
US-9,371,270 Compound for organic light-emitting device and organic light-emitting device including the same
Embodiments of the present disclosure are directed to a compound represented by Formula 1, and to organic light-emitting diodes including the compound. In some...
US-9,371,269 Method for preparing dialkyl carbonate
The present invention provides a method for preparing dialkyl carbonate from urea or alkyl carbamate and alkyl alcohol using an ionic liquid comprising a...
US-9,371,268 Method for producing asymmetric chain carbonate
An asymmetric chain carbonate can be produced in a single-step reaction comprising a step of reacting methyl nitrite, carbon monoxide, and 0.05-1.5 moles of an...
US-9,371,267 Cerium catalyzed production of secondary alcohols and plasticizers based on the secondary alcohols
A method for preparation of secondary alcohols with a high proportion of hydroxyl group at the C2 position is disclosed. Alkyl carboxylates, high in...
US-9,371,266 Copper-zirconia catalyst and method of use and manufacture
Catalysts and methods for their manufacture and use for the dehydrogenation of alcohols are disclosed. The catalysts and methods utilize a highly dispersible...
US-9,371,265 Compositions and methods related to inhibitors of JAK kinase
Embodiments are directed to JAK kinase inhibiting prodrug compounds of Formula Ib, containing a promoiety that results in alcohol derivative of the parent...
US-9,371,264 Treprostinil derivative compounds and methods of using same
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary...
US-9,371,263 Protective effects of curcumin against hemorrhagic stroke injury
Disclosed herein are compounds, compositions and methods for preventing and treating diseases such as intracerebral hemorrhage, cancer, or conditions associated...
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