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Treatment of glycogen storage disease type II
Methods of treating glycogen storage disease type II, by administering acid .alpha.-glucosidase, are described, as are compositions for use in treatment of...
Surfactant protein D for the treatment of disorders associated with lung
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of...
Method for treating breast cancer with prolactin receptor agonists
Disclosed herein are compositions and methods useful for the treatment of cancer, such as breast cancer. In some embodiments, the methods and compositions...
Methods for weight loss and ketogenic compositions
The present disclosure relates to a weight-loss composition including protein and fat and methods of use. The weight loss composition is substantially free of...
Protein A compositions and methods of use
Methods and compositions for modulating an immune response in a subject are provided. Methods include administering to the subject a composition comprising an...
Compositions and methods of treating head and neck cancer
The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In...
Oncolytic viruses and methods for treating neoplastic disorders
The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and...
Compositions and methods for treating and preventing hyperlipidemia, fatty
liver, atherosclerosis and other...
The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, ...
Methods of treating urogenital-neurological disorders using modified
The present specification discloses modified Clostridial toxins, compositions comprising such toxins and methods of treating urogenital-neurological disorders...
Compositions and methods for treating ischemia
The presently-disclosed subject matter provides methods for preventing ischemia in a cell, treating ischemia in a subject, and preventing an infarction in a...
N-acyldipeptide derivatives and their uses
N-acyldipeptide derivatives are described. Compositions comprising the N-acyldipeptide derivatives are therapeutically effective for topical or systemic...
Methods and compounds for intensive skin repair and healing including
active organic and synthetic compounds
A skin treatment compound includes Lidocaine and aloe vera. The aloe vera is Barbadensis Miller species. Optionally, the skin treatment compound includes...
Formulation of a mixture of free-B-ring flavonoids and flavans as a
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds--Free-B-ring flavonoids and...
Provided is a formulation including a variety of Chinese herbs for the treatment of a disease, such as cancer, and side effects associated with the treatment of...
Medical composition containing Stauntonia hexaphylla extract
Disclosed is an antipyretic drug comprising a Stauntonia Hexaphylla leaf extract as an active ingredient. The antipyretic drug is developed based on the finding...
Extract of the above-ground portions of gynandropsis gynandra or cleome
gynandra, and cosmetic, dermatological...
The invention relates to a composition, such as a cosmetic, dermatological, or pharmaceutical composition, including an extract of the above-ground portions of...
K2 composition and the preparation method and use of the same
A method for providing a K2-enriched FU-LING extract is provided. The method comprises the following steps: (a) mixing a FU-LING with a solvent to provide a...
Topical compositions and methods for alleviating or inhibiting symptoms
associated with carpal tunnel syndrome,...
A composition for, and method of, alleviating or inhibiting one or more symptoms associated with carpal tunnel syndrome, acid reflux, psoriasis, cartilage...
Non-replicating probiotic micro-organisms protect against upper
respiratory tract infections
The present invention relates to non-replicating probiotic micro-organisms and their health benefits. For example, the present invention relates to compositions...
Compositions and methods for reducing inflammation
Blue-green algae, such as Aphanizomenon flos aquae (AFA) or Spirulina (Arthrospira) can be fractionated. Anti-inflammatory aqueous fractions of blue-green algae...
Processed adipose tissue
The present disclosure provides tissue products produced from adipose-containing tissues, as well as methods for producing such tissue products. The tissue...
Method for treatment of advanced solid tumors
The present invention relates to the use of Volasertib or a salt thereof or a hydrate thereof in combination with Cisplatin or Carboplatin or a salt thereof or...
Pharmaceutical compositions containing biocidal co-polymers of poly(styrenes), poly(acrylates), poly(acrylamides), and poly(C.sub.1-C.sub.6)alkylene glycols are...
Wound healing compositions comprising microspheres
Pharmaceutical or medical compositions for treating a wound are provided, the composition comprise microspheres as an active ingredient and water as a carrier...
Prebiotic formulations and methods of use
The invention provides methods and compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal...
Method of providing patient specific immune response in amyloidoses and
protein aggregation disorders
A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response...
Combination, kit and method of reducing intraocular pressure
The present invention is directed to a composition or a kit comprising a combination of a prostaglandin analog and an adenosine receptor A.sub.1 agonist and to...
Tannin inhibitors of HIV
The invention provides a method to prevent or treat HIV-infection with synthetic tannins, and pharmaceutical compositions comprising synthetic tannins.
Compositions, methods of treatment and diagnostics for treatment of
hepatic steatosis alone or in combination...
The present invention is directed to pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and/or prevention of an...
Amelioration of intestinal fibrosis and treatment of Crohn's disease
Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or...
Combination hormone replacement therapy (HRT) and melatonin to prevent and
treat mammary cancer
A combination hormone and melatonin therapy is provided to reduce the risk of developing, or to reduce the severity of, breast cancer by administering at least...
Modified release preparations containing oxcarbazepine and derivatives
Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise...
Method for reducing radiation-induced normal tissue damage
The present invention provides compositions and methods for increasing therapeutic gain in radiotherapy and chemotherapy for proliferating malignant or...
Method for diagnosing or prediagnosing a beta-amyloidopathy or an
The invention relates to a method for the diagnosis or prediagnosis of a .beta.-amyloidopathy or an .alpha.-synucleopathy accompanied by a cerebral protein...
Heterocyclic compounds for the inhibition of PASK
Disclosed herein are new heterocyclic compounds having structural Formula IIa ##STR00001## and compositions and their application as pharmaceuticals for the...
Targeting GLI proteins in human cancer by small molecules
The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a GLI polypeptide....
Macrocyclic LRRK2 kinase inhibitors
The present invention relates to novel macrocylic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors...
Macrocyclic FLT3 kinase inhibitors
The present invention relates to macrocylic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of...
Sildenafil sublingual spray formulation
The invention is directed to sublingual spray formulations containing sildenafil. The invention is further directed to methods of treating male sexual...
Substituted pyrazolopyrimidines as Akt kinase inhibitors
Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. ##STR00001##
Use of ghrelin receptor inverse agonists or antagonists for treating sleep
The present invention relates to methods of treating sleep disorders in patients comprising administration of a ghrelin receptor inverse agonist or antagonist....
Mixed lineage kinase inhibitors and method of treatments
Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their...
Methods for fine particle manufacture
Processes for preparing micronized particles comprising a poorly water soluble bioactive agent are provided. The processes utilize a superheated aqueous phase...
Compositions and methods for increasing the metabolic lifetime of
dextromethorphan and related pharmacodynamic...
This disclosure relates to methods of increasing the metabolic lifetime of dextromethorphan administering threohydroxybupropion or bupropion to a human being....
Buprenorphine-wafer for drug substitution therapy
The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral,...
Morphinan-derivatives for treating diabetes and related disorders
The invention relates to a morphinan-derivative that targets NMDA receptors on pancreatic islets and has the general formula (I) ##STR00001## wherein ...
Small molecule compounds to treat hearing loss
The invention is directed, in part, to compositions comprising small molecule compounds to treat or prevent hearing loss. Compositions of the present invention...
2.times.2.times.2 week dosing regimen for treating actinic keratosis with
Pharmaceutical formulations and methods for the topical or transdermal delivery of 1-isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine or ...
Imidazoquinolines as dual lipid kinase and mTOR inhibitors
The invention relates to the use of compounds of formula (I) ##STR00001## in the treatment of mammalian target of rapamycin (mTOR) kinase dependent diseases,...
Pyridonyl guanidine F.sub.1F.sub.0-ATPase inhibitors and therapeutic uses
The invention provides pyridonyl guanidine compounds that inhibit F.sub.1F.sub.0-ATPase, and methods of using pyridonyl guanidine compounds as therapeutic...