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Patent # Description
US-9,382,307 Methods and composition for measuring the amount of vitamin D derivatives
Methods and compositions for measuring the amount of vitamin D derivatives are disclosed. Fluorescence Resonance Energy Transfer (FRET) in combination with a...
US-9,382,306 Octapeptide compounds derived from somatostatin and the therapeutic use thereof
The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal ...
US-9,382,305 Relaxin fusion polypeptides and uses thereof
The present invention provides Relaxin fusion polypeptides A-L-B with a non-wild type array of the Relaxin A-chain and Relaxin B-chain, wherein the A- and...
US-9,382,304 Engineered polypeptides having enhanced duration of action with reduced immunogenicity
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration, and reduced...
US-9,382,303 Vaccine for treatment of tautopathy
This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a...
US-9,382,302 Lutzomyia longipalpis polypeptides and methods of use
Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including...
US-9,382,301 Tubulin-interacting protein, caltubin, promotes axonal growth
A novel isolated protein, referred to herein as "caltubin", is provided. Caltubin promotes axonal regeneration, and prevents or at least reduces axonal...
US-9,382,300 Use of recombinant polypeptides from the genus Lupinus as antimicrobial or insecticidal on plants
This invention is related to a protein from the seeds, cotyledons or plantlets of Lupinus genus, as well as to the way of producing the protein in recombinant...
US-9,382,299 Polypeptides targeting glycosylated MUC2 proteins, methods of synthesis, their nucleic acids and uses thereof
The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence...
US-9,382,298 Polypeptide
The invention relates to a polypeptide, a corresponding nucleic acid molecule, a construct and/or vector and/or cell comprising such nucleic acid molecule...
US-9,382,297 Mutated protein of protein A having reduced affinity in acidic region and antibody-capturing agent
A modified protein of an extracellular domain of protein A, which has the reduced ability to bind to immunoglobulin in an acidic region, compared with the...
US-9,382,296 Truncated L1 protein of human papillomavirus type 58
Provided are an N-terminal truncated L1 protein of the Human Papillomavirus Type 58, a coding sequence and preparation method thereof, and a virus-like particle...
US-9,382,295 Cyclic depsipeptide compounds and their uses
The present invention relates to novel cycloundecadepsipeptide compounds and their analoges which bind and inhibit cyclophilins, have reduced immunosuppressive...
US-9,382,294 Broad spectrum antibiotic compounds and use thereof
The discovery of a non-ribosomal peptide synthetase (NRPS) gene cluster in the genome of Clostridium thermocellum that produces a secondary metabolite that is...
US-9,382,293 Modified kisspeptin peptides and uses thereof
The present application provides synthetic modified peptides of five to seven natural or non-natural amino acids as well as pharmaceutical compositions...
US-9,382,292 Cyclic tetrapeptides and therapeutic applications thereof
There are provided compounds of formula I: ##STR00001## wherein k, m, n, p, R, R', R'', R''', R.sup.3, R.sup.4, R.sup.7 and R.sup.8 are as defined in the...
US-9,382,291 Gamma amino acid building blocks
The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene...
US-9,382,290 Aptamer-modified polymeric materials for the binding of factors in a wound environment
The present invention provides aptamer-modified polymers and materials thereof, which may be used for the binding of factors in a wound bed. For example, the...
US-9,382,289 Tubulysin compounds, methods of making and use
Tubulysin compounds of the formula (I) ##STR00001## where R.sup.1, R.sup.2, R.sup.3a, R.sup.3b, R.sup.4, R.sup.5, W, and n are as defined herein, are...
US-9,382,288 Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
The present invention relates to compounds derived from steroids of the general formula (I) ##STR00001## wherein L represents a linker and R.sup.# represents...
US-9,382,287 Methotrexate adjuvants to reduce toxicity and methods for using the same
Methods are provided for using methotrexate (MTX) active agents in which reduced host toxicity is observed. Aspects of the methods include administering to a...
US-9,382,286 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is...
US-9,382,285 Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins, angiopoietins or...
US-9,382,284 Neuraminidase inhibitor compounds, compositions and methods for the use thereof in anti-viral treatments
Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for...
US-9,382,283 Oxygen assisted organosolv process, system and method for delignification of lignocellulosic materials and...
An oxygen assisted Organosolv process for a more efficient delignification and producing bio-products by decomposing lignocellulosic materials comprises...
US-9,382,282 Metal catalyzed oxidation of lignin and related compounds
Disclosed are methods for the benzylic oxidation of the lignin and related compounds. The methods include contacting lignin with a mixture containing manganese...
US-9,382,281 Nickel pre-catalysts and related compositions and methods
Described herein are nickel pre-catalysts and related compositions and methods. The nickel pre-catalysts may be activated to form catalysts which may be...
US-9,382,280 Diamine compound and metal complexes, and method for producing optically active compounds
The present invention relates to a diamine compound represented by the general formula (1), a ruthenium-diamine complex, an iridium-diamine complex, and a...
US-9,382,279 Copper catalyzed halogenaton and reaction products
A Cu(I)-catalyzed 1,3-halogen migration reaction effectively recycles an activating group by transferring a halogen from an sp.sup.2 to a benzylic carbon with...
US-9,382,278 Process for preparing ceftaroline fosamil
The present invention relates to a novel process for preparing ceftaroline fosamil via intermediates of Formulae (1), (3) or (4) of this process. ##STR00001##
US-9,382,277 Pyrimido-pyridazinone compounds and methods of use thereof
The present application provides novel pyrimido-pyridazinone compounds and methods for preparing and using these compounds. These compounds are useful in...
US-9,382,276 Water-soluble O-carbonyl phosphoramidate prodrugs for therapeutic administration
The present invention provides certain water-soluble O-carbonyl phosphoramidate prodrugs of the following formula I: ##STR00001## or pharmaceutically...
US-9,382,275 Preparation of phosphorus--containing antiwear composition for use in lubricant compositions
A process is provided for preparing a salt of a hydroxy-substituted di-ester of phosphoric acid, comprising: (a) reacting a phosphating agent with a monohydric...
US-9,382,274 Aqueous redox flow batteries featuring improved cell design characteristics
Provided are compositions having the formula M.sub.nTi(L1)(L2)(L3) wherein L1 is a catecholate, and L2 and L3 are each independently selected from catecholates,...
US-9,382,273 Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof
Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof.
US-9,382,272 Methods of making lubiprostone and intermediates thereof
There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing...
US-9,382,271 Process for the preparation of high purity norbornene alkanols and derivatives thereof
A process for the preparation of a variety of high purity norbornene alkanol monomers and their derivatives is disclosed and claimed. Specifically, a process...
US-9,382,270 Substituted silacyclopropane precursors and their use for the deposition of silicon-containing films
Provided are silacyclopropane-based compounds and methods of making the same. Also provided are methods of using said compounds in film deposition processes to...
US-9,382,269 Halogen free syntheses of aminosilanes by catalytic dehydrogenative coupling
Compounds and method of preparation of Si--X and Ge--X compounds (X.dbd.N, P, As and Sb) via dehydrogenative coupling between the corresponding unsubstituted...
US-9,382,268 Sulfur containing organosilane precursors for ALD/CVD silicon-containing film applications
Disclosed are sulfur containing organosilane precursors, methods of synthesizing the same, and methods of using the same to deposit silicon-containing films...
US-9,382,267 Small molecule inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
The present invention relates to novel compounds, their use as anti-cancer agents and their synthesis. In particular, the compounds contain cluster boron...
US-9,382,266 Rapamycin analogue
There is provided inter alia a compound of formula (I) or a pharmaceutically acceptable salt thereof and its use in therapy. ##STR00001##
US-9,382,265 Oxazolidone compound, preparing method and application thereof
The present invention relates to the field of a pharmaceutical compound, and more specifically, relates to a new oxazolidone compound, an enantiomer, a...
US-9,382,264 Conveniently prepared naphthalene and perylene derivatives as building blocks for organic electronic materials...
The present invention provides the compounds of formulae (3) and (1), wherein n is 0 or 1, R.sup.11 and R.sup.12 are the same and are selected from the group...
US-9,382,263 Therapeutically active oxazoline derivatives
Compounds of formula (I) i.e. monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives substituted by an...
US-9,382,262 Compounds useful in the synthesis of halichondrin B analogs
In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts...
US-9,382,261 Substituted quinazolinones as HCV inhibitors
Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, salts, and solvates thereof, wherein R and R' have the meaning as...
US-9,382,260 Buprenorphine analogs
The present invention is directed to Buprenorphine Analog compounds of Formula I, II, III, IV or V and including various stereoisomers (such as Formula IA shown...
US-9,382,259 Compounds with oxime ester and/or acyl groups
There are provided compounds comprising optionally substituted (FORMULA I) fused with one or two optionally substituted (FORMULA II), wherein A and E each...
US-9,382,258 Agents for treating pain and uses thereof
This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and...
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