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Patent # Description
US-9,388,458 Methods, systems, and compositions for detection of microbial DNA by PCR
This invention provides methods, systems, and compositions for detecting low abundance microbial DNA in a sample by PCR. Methods of the present invention are...
US-9,388,457 Locus specific amplification using array probes
Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets. In preferred aspects the amplification and...
US-9,388,456 Compositions and methods for performing a stringent wash step in hybridization applications
The invention provides methods and compositions for performing a stringent wash step in a hybridization assay between at least one molecule and a target. The...
US-9,388,455 Double stranded linear nucleic acid probe
A double-stranded nucleic acid hybridization probe and methods of using the same are described. The probe described is particularly suited for real-time RT-PCR...
US-9,388,454 Method for producing protein-nucleic acid conjugate, and method for detecting target substance
Provided is a method for producing a nucleic acid probe that can detect a target substance with good sensitivity. A method for producing a nucleic acid probe,...
US-9,388,453 Non-replicative transduction particles and transduction particle-based reporter systems
Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The...
US-9,388,452 Methods for modeling protein stability
The present invention relates to a method for determining the highest temperature that is suitable for performing accelerated protein stability studies, as well...
US-9,388,451 Medical device design, manufacture and testing systems
Described are methods and systems for testing lumens of cannulated delivery components or assemblies thereof that may be used to deliver cells to a patient....
US-9,388,450 FRET based multiplex probes
The present invention includes compositions and methods for fluorescence-based multiplex probe to simultaneously detect one or more enzymatic activities...
US-9,388,449 Monitoring protein trafficking using beta-galactosidase reporter fragment complementation
Methods and materials are disclosed for use in an enzyme fragment complementation assay using complementary fragments of .beta.-galactosidase to study the...
US-9,388,448 System and method for processing samples
A system and method for processing samples. The system can include a loading chamber, a detection chamber positioned in fluid communication with the loading...
US-9,388,447 Method for culturing mammalian cells to improve recombinant protein production
The present invention relates to methods for mammalian cell culture. The methods make use of independent tyrosine and cystine feed streams.
US-9,388,446 Methods of producing hybrid antibodies
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and...
US-9,388,445 Enhancement of in vitro translation by nanoparticle conjugates
Provided herein are kits and methods suitable for enhancing in vitro translation of a nuclei acid sequence of interest.
US-9,388,444 Use of glucosyltransferase gene
The isolation and characterization of a glucosyltransferase gene from Candida bombicola is disclosed. Use of the glucosyltransferase enzyme for the production...
US-9,388,443 Lactonase derived from Candida bombicola and uses thereof
The present disclosure relates to an enzyme derived from Candida bombicola that is capable of lactonizing or polymerizing carbohydrate-containing compounds,...
US-9,388,442 Reconfigureable processing enclosures
Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) or other materials are processed to produce useful intermediates and products, such...
US-9,388,441 Genetically modified microorganisms capable of producing .beta.-glucans and methods for producing .beta.-glucans
The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified...
US-9,388,440 Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an ...
The present invention provides an enzymatic process for the preparation of (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by the reduction of...
US-9,388,439 Acetyltransferase from wickerhamomyces ciferrii
The invention relates to novel enzymes that provide acetylated sphingoid bases.
US-9,388,438 Enone reductases
The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related...
US-9,388,437 Acyltransferases and uses thereof in fatty acid production
The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides,...
US-9,388,436 Fatty acid desaturase and uses thereof
The present invention relates to nucleic acids derived from Limonomyces roseipellis. The invention also relates to the individual coding sequences and to...
US-9,388,435 Microbial oils with lowered pour points, dielectric fluids produced therefrom, and related methods
Methods and compositions for the production of dielectric fluids from lipids produced by microorganisms are provided, including oil-bearing microorganisms and...
US-9,388,434 Synthesis of short chain fatty acids from bacteria
The present invention relates to an engineered bacteria for producing short chain fatty acid with the overexpression of a long chain (>C12) acyl-ACP...
US-9,388,433 Method for producing polymer, method for producing organic acid, and organic acid-producing microorganism
The present invention provides a method of producing a polymer, which comprises the step of performing a polymerization reaction using, as a starting material,...
US-9,388,432 Processing biomass
Carbon-containing materials, such as biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) or coal are processed to produce useful...
US-9,388,431 Enhanced production of isoprene using host cells having decreased ispA activity
This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with...
US-9,388,430 Cas9-recombinase fusion proteins and uses thereof
Some aspects of this disclosure provide compositions, methods, and kits for improving the specificity of RNA-programmable endonucleases, such as Cas9. Also...
US-9,388,429 Method for propagating adenoviral vectors encoding inhibitory gene products
The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic...
US-9,388,428 Compositions and methods related to viruses of the genus Negevirus
Certain embodiments are directed to Negevirus and their polynucleotides and polypeptides.
US-9,388,427 In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a...
US-9,388,426 Methods and compositions for inactivating glutamine synthetase gene expression
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a...
US-9,388,425 Tunable genetic switch for regulating gene expression
The present invention relates generally the field of genetics, in particular methods, compositions and systems for controlling the inducible expression of...
US-9,388,424 Soybean variety DLL1335
The soybean variety DLL1335 is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and soybean lint as well as to...
US-9,388,423 Plants having enhanced yield-related traits and a method for making the same
The present invention relates generally to the field of molecular biology and concerns a method for enhancing yield-related traits in plants by modulating...
US-9,388,422 Cellulosic processing trait development using a thermoregulated, intein-modified xylanase
In planta consolidated bioprocessing has the advantages of decreasing biomass pretreatment costs, utilizing excess plant protein production capacity for enzyme...
US-9,388,421 Enhanced expression method
The present invention concerns a method of producing a desired heterologous gene product wherein said heterologous gene product is expressed from a strong...
US-9,388,420 Alkynyl-derivatized cap analogs, preparation and uses thereof
Alkynyl-derivatized cap analogs, alkynyl-modified capped RNA, 1,4-disubstituted triazole-derivatized capped RNA, methods of preparation, methods of isolation,...
US-9,388,419 Methods for producing 3-hydroxypropionic acid and other products
This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA...
US-9,388,418 Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
An aptamer-mRNA conjugate is provided. The aptamer-mRNA conjugate may include an aptamer component that binds a membrane associated protein on a target cell and...
US-9,388,417 Synthesis-regulating sRNA and method for preparing same
The present invention relates to a novel customized sRNA that reduces gene expression in prokaryotic cells, a preparation method thereof, and the use thereof,...
US-9,388,416 Modified oligonucleotides for telomerase inhibition
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is...
US-9,388,415 Modified oligonucleotides for telomerase inhibition
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is...
US-9,388,414 Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating...
US-9,388,413 Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative...
US-9,388,412 Inhibitors of microRNAs that regulate production of atrial natriuretic peptide (ANP) as therapeutics and uses...
The present invention relates to methods, kits and compositions to treat hypertension and other cardiovascular diseases in a subject, in particular, a method of...
US-9,388,411 miRNA-212/132 family as a therapeutic target
The present invention refers to inhibitors of microRNAs, particularly of microRNAs miR-212 and/or miR-132 for use in medicine, particularly in the diagnosis,...
US-9,388,410 Alternative export pathways for vector expressed RNA interference
The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using...
US-9,388,409 Identification and use of target genes for control of plant parasitic nematodes
The invention relates to identifying and evaluating target coding sequences for control of plant parasitic nematodes by inhibiting one or more biological...
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