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Patent # Description
US-9,388,408 Oligonucleotide-based inhibitors comprising locked nucleic acid motif
The present invention relates to chemical modification motifs for oligonucleotides. The oligonucleotides of the present invention, such as chemically modified...
US-9,388,407 Methods and devices for nucleic acid synthesis
Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary...
US-9,388,406 System useful for reporting protein-protein interactions in the bacterial periplasm
One aspect of the present invention relates to a reporter system for detection of protein-protein interactions in the periplasm of a prokaryotic host cell. The...
US-9,388,405 Method for identifying a subpopulation of mammalian cells with distinctive ribosome translation profiles
The present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. translational activities....
US-9,388,404 Protein disulfide isomerase assay method for the in vitro diagnosis of colorectal cancer
A method for the in vitro diagnosis of colorectal cancer that comprises determining the presence of the protein disulfide isomerase tumor marker in a biological...
US-9,388,403 Nitrile hydratase
Improving wild nitrile hydratase enables the provision of a protein which has nitrile hydratase activity and which has further improved heat resistance, amide...
US-9,388,402 Method for improved isolation of recombinantly produced proteins
The present invention provides a method for increasing the yield of a protein produced by cultivating eukaryotic cells and adding an ionic substance to the...
US-9,388,401 Antidotes for factor Xa inhibitors and methods of using the same
The present invention relates antidotes to anticoagulants targeting factor Xa. The antidoes are factor Xa protein derivatives that bind to the factor Xa...
US-9,388,400 Composition for use in mycobacteria diagnosis
The present invention relates to a composition having the activity of degrading the cell wall of a Mycobacterium species comprising: (a) a first fusion protein...
US-9,388,399 Development of strains of the thermotolerant yeast Hansenula polymorpha capable of alcoholic fermentation of...
Genes SWA2 and GAM1 from the yeast, Schwanniomyces occidentalis, encoding .alpha.-amylase and glucoamylase, respectively, were cloned and expressed in H....
US-9,388,398 Alteration and modulation of protein activity by varying post-translational modification
Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a...
US-9,388,397 Deimmunized gelonin molecules and therapies
Recombinant gelonin polypeptides with decreased antigenicity are provided. Cell-targeted constructs comprising said recombinant gelonin polypeptides are also...
US-9,388,396 Chimeric DNA polymerases
The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA...
US-9,388,395 Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host...
US-9,388,394 Vaccines against clostridium difficile comprising recombinant toxins
The present invention relates to recombinant C. difficile toxin A (TcdA) and toxin B (TcdB) and binary toxin A (CDTa) proteins comprising specifically defined...
US-9,388,393 Mutant hydroxyphenylpyruvate dioxygenase polypeptides and methods of use
Compositions and methods for conferring hydroxyphenyl pyruvate dioxygenase (HPPD) herbicide resistance or tolerance to plants are provided. Compositions include...
US-9,388,392 Ketol-acid reductoisomerase enzymes and methods of use
Provided herein are polypeptides having ketol-acid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided...
US-9,388,391 Biocatalysts for Ezetimibe synthesis
The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of...
US-9,388,390 Method for preparing virus-like particle and recombinant baculovirus used therein
A recombinant baculovirus is provided for preparing picornavirus virus-like particles (VLP), wherein Chitinase A (ChiA) and Cathepsin V (v-cath) genes of the...
US-9,388,389 JFH-1 based HCV cell culture systems for NS5A of genotypes 1-7
The present inventors developed hepatitis C virus recombinants expressing NS5A from genotype 1a, 1b, 2a, 3a, 4a, 5a, 6a or 7a in the context of a genotype 2a...
US-9,388,388 Methods for making cells with an extra-embryonic endodermal precursor phenotype
The invention is directed to methods for making cells in vitro that have an extra-embryonic endodermal precursor phenotype. The method involves culturing cells...
US-9,388,387 Differentiation of human embryonic stem cells
The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to...
US-9,388,386 Differentiation of human embryonic stem cells into single hormonal insulin positive cells
The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides methods to...
US-9,388,385 Methods for treating obesity and/or metabolic syndrome
The present disclosure provides methods of treating or preventing obesity or causing weight loss or treating or preventing metabolic syndrome comprising...
US-9,388,384 Mesenchymal stem cells produced from human pluripotent stem cells
Provided is a method for producing mesenchymal stem cells from human pluripotent stem cells, the method including: a) forming embryonic bodies from human...
US-9,388,383 Method for collecting red blood cells
A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood...
US-9,388,382 Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from...
The present invention is related generally to embryonic-like stem cells isolated from human umbilical cord blood, designated herein as cord blood-stem cells...
US-9,388,381 Methods and compositions for increased safety of stem cell-derived populations
The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to...
US-9,388,380 Method for producing continuous cell lines
The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said...
US-9,388,379 Dynamically alterable cell support
A dynamically alterable cell support may be altered at a large scale to induce mechanical removal of adherent cells in culture without the use of a removal...
US-9,388,378 Candida sake strain for producing long chain dicarboxylic acids
A strain of Candida sake, CAT H430, is provided. The methods of using CAT H430 for producing dicarboxylic acids are also provided.
US-9,388,377 Regenerative cell extraction unit and regenerative cell extraction system
Provided is a regenerative cell extraction system. The regenerative cell extraction system includes: a regenerative cell separation unit which separates fat...
US-9,388,376 Method for counting subject matters to be counted in container
A method for counting counted targets disposed in a liquid enclosed in a container, includes adjusting a thickness of at least a part of the container; setting...
US-9,388,375 Methods and apparatus for gas stream mass transfer with a liquid
A method and system for achieving a gas-liquid mass transfer includes delivering into a compartment of a container a liquid, the liquid having an exposed top...
US-9,388,374 Microfluidic cell culture systems
In one embodiment, a microfluidic structure comprises a culture chamber having an object flow inlet disposed between a pair of object flow outlets. A...
US-9,388,373 Microscale bioprocessing system and method for protein manufacturing
A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic...
US-9,388,372 Bioreactor using macroalgae
The invention features a bioreactor for the growth of macroalgae and methods for using the bioreactor to maintain optimal nutrient levels for the organisms in...
US-9,388,371 Electrolytic copper foil, cleaning fluid composition and method for cleaning copper foil
An electrolytic copper foil includes a copper foil body; and a IIA-group metal adhered to a surface of the copper foil body, wherein a signal strength of the...
US-9,388,370 Thermolysin-like protease for cleaning insect body stains
A substrate or coating is provided that includes a protease with enzymatic activity toward a component of a biological stain. Also provided is a process for...
US-9,388,369 Wash water maintenance for sustainable practices
Methods for use of enzymes for sustainable wash water maintenance are disclosed. The invention relates to use of enzymes for removing soils from wash water...
US-9,388,368 Cleaning compositions containing a polyetheramine
The present invention relates generally to cleaning compositions and, more specifically, to cleaning compositions containing a polyetheramine that is suitable...
US-9,388,367 Esterquat composition having high triesterquat content
A composition comprising (a) an esterquat that is a quaternized reaction product of an alkanol amine and a fatty acid, wherein from at least 90 wt % to up to...
US-9,388,366 Solid concentrated fabric softener composition
A solid fabric softening composition is disclosed which includes a quaternary ammonium fabric softening compound which is stabilized to form a solid with a...
US-9,388,365 Wooden wicks including a booster for a candle and method of making
A wooden wick for use in a wax candle comprising a strip of predetermined wood having each of a first predetermined length, a first predetermined width and a...
US-9,388,364 Liquefaction processes and systems and liquefaction process intermediate compositions
Liquefaction processes are provided that can include: providing a biomass slurry solution having a temperature of at least 300.degree. C. at a pressure of at...
US-9,388,363 Ultrasonic and megasonic method for extracting palm oil
A process for extracting palm oil includes an ultrasonic horn press and a megasonic clarifier. The ultrasonic horn press uses ultrasonic vibrations to rupture...
US-9,388,362 Friction modifiers and a method of making the same
A lubricating oil additive composition comprising the reaction product of an (a) an alkylated aromatic ether alcohol, (b) a source of boron, and (c) a...
US-9,388,361 Lubricating oil additive composition and lubricating oil composition
A lubricating oil additive composition contains a borated succinimide derivative and an amino alcohol compound. A lubricating oil composition containing the...
US-9,388,360 Nanostructure of a revitalizing agent and method for producing a stable form of a nanostructure of a...
The invention relates to the production of materials which can be used in lubricating compositions for treating friction assemblies and also for restoring the...
US-9,388,359 High octane unleaded aviation gasoline
High octane unleaded aviation gasoline having low aromatics content and a T10 of at most 75.degree. C., T40 of at least 75.degree. C., a T50 of at most...
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