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Patent # Description
US-9,388,206 Chromophores with perfluoroalkyl substituents
The present invention relates to specific metal complexes of dithiolenes with perfluoroalkyl substituted imidazolidine-2-chalcogenone-4,5-dithione ligands, a...
US-9,388,205 Ni complex and its derivatives, producing method, and the use thereof as an antioxidant
The present invention relates to a novel nickel complex and its derivatives, which mimic the active site of Ni-containing superoxide dismutase (NiSOD). The...
US-9,388,204 Extraction solvent control for reducing stable emulsions
Disclosed herein are methods for recovering diphosphite-containing compounds from mixtures comprising organic mononitriles and organic dinitriles, using...
US-9,388,203 Pharmaceutical process and intermediates
The present disclosure provides for processes and intermediates in the large-scale manufacture of the compound of formula (I) or hydrates thereof. ##STR00001##
US-9,388,202 Luminescent probes for biological labeling and imaging, method for preparing same
The present invention relates to organic compounds that are usable as ligands for preparing complexes of lanthanides or of certain transition metals which are...
US-9,388,201 Urea-containing silanes, process for preparation thereof and use thereof
The invention relates to urea-containing silanes of the formula I ##STR00001## which are prepared by, in a first step, reacting an aminosilane of the formula...
US-9,388,200 Urea-containing mercaptosilanes, process for preparation thereof and use thereof
The invention relates to urea-containing mercaptosilanes of the formula I ##STR00001## which are prepared by reacting a halosilane of the formula II ...
US-9,388,199 Pyrrolidine derivatives and their use as complement pathway modulators
The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention and its therapeutic uses as complement...
US-9,388,198 Heterocyclic amide derivatives as P2X.sub.7 receptor antagonists
The invention relates to heterocyclic amide derivatives of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, n and X are as defined in the...
US-9,388,197 Heterocyclic amide derivatives as P2X7 receptor antagonists
The invention relates to heterocyclic amide derivatives of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, n, m, p and X are as...
US-9,388,196 Thiazole derivatives as alpha 7 nAChR modulators
Disclosed is a compound of formula (I) wherein Y, Ring D, m and R.sup.1-R.sup.4 are as described herein, as a modulator of nicotinic acetylcholine receptors...
US-9,388,195 Heterocyclic compound
Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): ##STR00001## ...
US-9,388,194 Acrylic compound having tetraoxaspiro backbone for radiation curing compositions
Disclosed is a process for obtaining an acrylic compound having a tertaoxaspiro backbone and at least one acrylic unsaturation. Said compound is in embodiments...
US-9,388,193 Dipicolylamine derivatives and their pharmaceutical uses
Dipicolylamine compounds of Formula (I) set forth herein. Also disclosed are pharmaceutical compositions containing metal ions and these compounds. Further...
US-9,388,192 Benzimidazole derivatives as Kinase Inhibitors
The present invention relates to derivatives of benzimidazoles of formula (I) as disclosed herein as well as pharmaceutical compositions comprising said...
US-9,388,191 Fused imidazole derivatives useful as IDO inhibitors
Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating...
US-9,388,190 Liver X receptor modulators
Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions...
US-9,388,189 Pyrrolotriazinone derivatives as PI3K inhibitors
New pyrrolotriazinone derivatives having the chemical structure of Formula (I) are disclosed; as well as process for theft preparation, pharmaceutical...
US-9,388,188 Synthetic route for the preparation of .beta.-aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha...
The present invention relates to a process for preparing .quadrature.-aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-.alpha.]pyrazin-7-yl compounds.
US-9,388,187 Pyrrolobenzodiazepines
A compound with the formula I: wherein: R.sup.2 is of formula II: where A is a C.sub.5-7 aryl group, X is selected from the group comprising: NHNH.sub.2,...
US-9,388,186 Preparation of crystalline forms of dihydropyrazolopyrimidinone
The instant invention relates to crystalline forms of MK-1775, an inhibitor of Weel kinase. Specifically, the instant invention relates to hemihydrates of MK-1775.
US-9,388,185 Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
The present invention relates to pyrazine derivatives of Formula I, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR...
US-9,388,184 Intermediate of Ertapenem, a composition comprising the same and preparation methods thereof
Intermediates of Ertapenem of formula 2a wherein Np represents (I) or (II), and P.sub.1 and P.sub.2 represent carboxyl protecting groups, and their preparation...
US-9,388,183 Heterocyclic compounds and uses thereof
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods...
US-9,388,182 Process for converting lupanine into sparteine
The present invention relates to processes for preparing enantiopure Lupanine and Sparteine.
US-9,388,181 Substituted 1,2,3,4-tetrahydropyrido[3,4-E] pyrrolo[1,2-A]pyrimidines as kinase
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit...
US-9,388,180 Inhibitor compounds of phosphodiesterase type 10A
The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof. ...
US-9,388,179 N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels
Disclosed are compounds of Formula A.sup.A and Formula A.sup.B: wherein "Heteroaryl-1", R.sup.A1, R.sup.A2, R.sup.B1, and R.sup.C are defined herein, which...
US-9,388,178 Process for the preparation of moxifloxacin hydrochloride
The present invention relates to an improved and industriously advantageous process by means of providing coupling/condensing of wet mass of...
US-9,388,177 Method for preparing substituted triazolopyridines
The present invention relates to methods of preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as...
US-9,388,176 Method of treating conditiions with kinase inhibitors
The present invention relates to a method of treating ophthalmic diseases and conditions, e.g. diabetic retinopathy, age-related macular degeneration,...
US-9,388,175 2-aniline-4-aryl substituted thiazole derivatives
This invention concerns the use of a compound of formula (I) ##STR00001## a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a...
US-9,388,174 Azole benzene derivative
The present invention provides: a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which has an excellent inhibitory activity...
US-9,388,173 PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
US-9,388,172 Substituted carbamate compounds
The invention is concerned with the compounds of formula (I): ##STR00001## and pharmaceutically acceptable salts thereof. In addition, the present invention...
US-9,388,171 Serine/threonine kinase inhibitors
Compounds having the formula I wherein R.sup.2, X and Z as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating...
US-9,388,170 Substituted aminoquinazolines useful as kinases inhibitors
The present invention is directed to novel quinazolines, their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and...
US-9,388,169 Use of 15-benzylidene-14-deoxy-11, 12-dehydroandrographolide derivative in manufacture of medicaments for...
Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and...
US-9,388,168 Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine
The present invention relates to a novel process for the preparation of of the formula (I) (I) wherein R.sup.1 and R.sup.2 are described herein. The compounds...
US-9,388,167 Process for the preparation of voriconazole and analogues thereof
The present invention provides a process for preparing a compound of formula: (Formula XI and XII) (XI) (XII) wherein X, Y, Z, A, B and E are as defined herein,...
US-9,388,166 6-aminoindole derivatives as TRP channel antagonists
The invention is concerned with the compounds of formula (I) ##STR00001## and pharmaceutically acceptable salts thereof. In addition, the present invention...
US-9,388,165 Isoquinoline-5-carboxamide derivative having inhibitory activity for protein kinase
A compound selected from the group consisting of an isoquinoline-5-carboxamide derivative of formula (I), a pharmaceutically acceptable salt, an isomer, a...
US-9,388,164 Methods of using pyruvate kinase activators
Described herein are methods for using compounds that activate pyruvate kinase.
US-9,388,163 Multifunctional radical quenchers for the treatment of mitochondrial dysfunction
The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula: ...
US-9,388,162 Substituted morphinans and the use thereof
The application is directed to compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2,...
US-9,388,161 Tetrahydroquinoline compositions as BET bromodomain inhibitors
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases,...
US-9,388,160 Quinazoline derivatives as kinases inhibitors and methods of use thereof
The present invention is directed to novel quinazolines, their derivatives, pharmaceutically acceptable salts, solvates, prodrug, stereoisomer, tautomer,...
US-9,388,159 Substituted diazaspiroalkanes as androgen receptor modulators
This invention provides for compounds of the Formula II: ##STR00001## wherein A, B, Het, R.sub.1, R.sub.2 and R.sub.3 are as described herein. These compounds...
US-9,388,158 Production method for cyclopentanone derivative, intermediate compound, and production method for intermediate...
The present invention is a production method for a compound represented by the following general formula (V), the method comprising a step of obtaining a...
US-9,388,157 Bicyclic compound and use thereof for medical purposes
Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof, a solvate...
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