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Patent # Description
US-9,394,560 Method of culturing E. coli cells for high density
Disclosed is a method of culturing E. coli cells for high density, comprising a cell growth step and an expression induction step by which a maximum of cell...
US-9,394,559 Lactonase derived from candida bombicola and uses thereof
Described is an enzyme derived from Candida bombicola that is capable of lactonizing or polymerizing carbohydrate-containing compounds, lipids, fatty acids,...
US-9,394,558 Methods for extraction and purification of gangliosides
Methods for purification and extraction of GM1 ganglioside from cells derived from sheep afflicted with GM1 gangliosidosis or from cells derived from human...
US-9,394,557 Linear amplification of short nucleic acids
The present teachings provide novel methods for amplifying short nucleic acids. In some embodiments, the present teachings provide novel methods for linearly...
US-9,394,556 Polypeptides having glucuronyl esterase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having glucuronyl esterase activity, catalytic domains and polynucleotides encoding the polypeptides or...
US-9,394,555 Compositions comprising a polypeptide having cellulolytic enhancing activity and a dioxy compound and uses thereof
The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a dioxy compound. The present invention also...
US-9,394,554 Mutant xylanase, manufacturing method and use therefor, and method for manufacturing saccharified lignocellulose
What is aimed at is provision of an inexpensive and efficient saccharification method for lignocellulose using a thermostable xylanase and provision of a mutant...
US-9,394,553 Biosynthetic gene cluster for chejuenolide of marine microorganism Hahella chejuensis
The present invention relates to a biosynthetic gene cluster for a chejuenolide of the marine microorganism Hahella chejuensis, and to the function of an enzyme...
US-9,394,552 Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme....
US-9,394,551 Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In...
US-9,394,550 Lauric ester compositions
Provided are compositions containing alkyl esters derived from triglyceride oils produced from genetically engineered microalgae. Specific embodiments relate to...
US-9,394,549 Method for producing useful chemical substance from terephthalic acid potassium salt
TPA-DHD can be produced by using, as a raw material, terephthalic acid salt that contains 0.5 times or more and twice or less the amount of potassium based on...
US-9,394,548 Method of processing organic waste
Wheat bran culture mix is used to inoculate organic waste and produce an inoculated waste material, where the wheat bran culture mix includes soil derived...
US-9,394,547 Method and apparatus for delivery of molecules to cells
The present invention is concerned with a system and method for introducing a substance into cells. The system has an assembly including a plurality of elongate...
US-9,394,546 Recombinant yeast transformant and process for preparing immunoglobulin Fc fragment employing the same
The present invention relates to a transformant prepared by introducing an expression vector comprising a polynucleotide encoding for a human immunoglobulin Fc...
US-9,394,545 Methods and compositions for regulation of transgene expression
Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom.
US-9,394,544 Ameliorating oxidative stress in neurodegenerative disease via Nox1 targeting
Disclosed herein are methods, compounds and compositions designed for ameliorating oxidative stress in cells. In particular, disclosed are viral vectors that...
US-9,394,543 Materials and methods related to MicroRNA-21, mismatch repair, and colorectal cancer
Described herein is the discovery that miR-21 targets and down-regulates the core mismatch repair (MMR) recognition protein complex hMSH2 and hMSH6. Anti-sense...
US-9,394,542 Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Discs large homolog (DLG), in particular, by...
US-9,394,541 Oral delivery of nucleic acid-based gene interfering agents by Salmonella
The present invention provides vectors, including a novel attenuated strain of Salmonella, for efficient gene transfer into an animal, e.g. a mammalian host.
US-9,394,540 Modified iRNA agents
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The...
US-9,394,539 Survival motor neuron gene (SMN2) mRNA constructs for post-transcription regulation
The present invention provides compounds and assays for the identification and validation of compounds for use in the treatment of spinal muscular atrophy...
US-9,394,538 Development of universal cancer drugs and vaccines
This invention generally relates to a design and method for developing novel anti-tumor/cancer drugs, vaccines and therapies, using microRNA (miRNA) and its...
US-9,394,537 Continuous directed evolution
The invention provides systems, methods, reagents, apparatuses, vectors, and host cells for the continuous evolution of nucleic acids. For example, a lagoon is...
US-9,394,536 Identifying affinity-matured human antibodies
Antigen-specific immunoglobulin V-regions are identified from a library of nucleic acids amplified using polymerase chain reaction using leader ...
US-9,394,535 Plasma irradiation device for substance introduction and substance introduction method using plasma irradiation...
Disclosed is a liquid culture medium for substance introduction, which is capable of increasing the survival rate of cells after substance introduction as much...
US-9,394,534 Method and means for enrichment, removal and detection of gram-positive bacteria
The present invention relates to polypeptides comprising a enzymatically non-active cell wall binding domain of an endolysin or another cell wall lysing enzyme,...
US-9,394,533 Thermostable alpha-amylases
The present invention relates to an isolated polynucleotide comprising an open reading frame encoding a polypeptide having alpha-amylase activity, the...
US-9,394,532 Stabilization of alpha-amylases towards calcium depletion and acidic pH
The present invention relates to variants of a parent alpha-amylase, the variant having improved stability or activity at low calcium conditions or at low pH.
US-9,394,531 Compositions for linking DNA-binding domains and cleavage domains
Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases....
US-9,394,530 Lipase variants and polynucleotides encoding same
The present invention relates to lipase variants and methods of obtaining them. The present invention also relates to polynucleotides encoding the variants;...
US-9,394,529 Phospholipases, nucleic acids encoding them and methods for making and using them
In alternative embodiments, the invention provides phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes, nucleic acids encoding them, antibodies that...
US-9,394,528 Gene products of Bacillus licheniformis which form odorous substances and improved biotechnological production...
The present invention relates to 25 hitherto undescribed genes of B. licheniformis and gene products derived therefrom and all sufficiently homologous nucleic...
US-9,394,527 Manipulation of organic acid biosynthesis and secretion
The present invention relates to nucleic acid fragments encoding amino acid sequences for organic acid biosynthetic enzymes in plants, and the use thereof for...
US-9,394,526 FROG/TOAD conditionally silenced vectors for hypoxia gene therapy
Methods and compositions for the treatment of hypoxia associated disorders by directional angiogenesis/arteriogenesis. Conditionally silenced vectors expressing...
US-9,394,525 Generation of patient-specific differentiated cell types by epigenetic induction
Disclosure of a mammalian cytoplasmic donor cell line. Disclosure of a patient specific cell line. Methods to obtain a mammalian cytoplasmic donor cell line by...
US-9,394,524 Chemical approaches for generation of induced pluripotent stem cells
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing...
US-9,394,523 Induced pluripotent stem cells derived from human pancreatic beta cells
A method of generating pluripotent stem cells is described. The method comprises: (a) expanding human pancreatic beta cells; and subsequently (b) generating...
US-9,394,522 Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of...
Provided are improved methods using Glycogen synthase kinase 3 (GSK3) inhibitors by which endodermal cells, notably endodermal cells derived from human...
US-9,394,521 Cell preparation containing mesenchymal stem cells, and method for producing same
A cell preparation containing mesenchymal stem cells whose immunosuppression ability is maintained is produced by means of a serum-free or low-serum culture. A...
US-9,394,520 Expansion of hematopoietic stem cells
Described herein are methods, compositions and kits related to manipulating hematopoietic stem cells and more particularly to methods, compositions and kits...
US-9,394,519 Methods to produce mast cell culture
The present invention relates to mast cell cultures that are derived from hematopoietic progenitors and the use thereof. The invention describes a method for...
US-9,394,518 Method of preparing red blood cell and platelet products
This disclosure provides methods for preparing both a red blood cell (RBC)-containing product and a platelet-containing product from a plurality of blood units....
US-9,394,517 CD4+ T-cells with cytolytic properties
The present invention relates to CD4+ T cells, more specifically cytolytic or cytotoxic CD4+ T-cells and methods of obtaining and identifying them.
US-9,394,516 Self-renewal promoter for neural stem cells and method for using same
An object of the present invention to provide an agent for promoting the self-renewal of the neural stem cells and a method of using the same. ECF-L contained...
US-9,394,515 Poultry performance
Methods for increasing breast muscle weight in poultry are disclosed herein. These methods can include delivery of compositions via in ovo administration. The...
US-9,394,514 Culture substrate, culture sheet, and cell culture method
Disclosed is a culture sheet which enables technology in which three-dimensional tissues with uniform diameter are formed without applying chemicals to the...
US-9,394,513 Method for fermentation and cultivation, fermented plant extract, fermented plant extract powder, and...
For the purpose of providing a method of safely and inexpensively producing a fermented plant extract containing an immunopotentiator at a high concentration,...
US-9,394,512 Method for growing mycological materials
The method of growing the basidiomycete mycelium includes inoculating a substrate that promotes the growth and differentiation of basidiomycete mycelium without...
US-9,394,511 Rapid single cell based parallel biological cell sorter
A disposable rapid cell sorter comprises of microfluidic chip with electrodes and sorts biological cells of interest through magnetic field and electric field...
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