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Patent # Description
US-9,399,664 Process for purification of pneumocandin
The process described herein discloses purification process of a secondary metabolite produced by fermentation route. The process involves selective removal of...
US-9,399,663 Competitive inhibitor of GP120
Peptides and peptide analogs that competitively inhibit HIV protein gp120 and methods for making and using the same.
US-9,399,662 Concurrent chemotherapy and immunotherapy
The concurrent administration of chemotherapy and immunotherapy has been considered a contraindication because of the concern that the induced lymphopenia would...
US-9,399,661 Tetrapeptide copper catalysts capable of oxidizing hydrocarbons at room temperature
The present invention relates to peptide copper catalysts capable of oxidizing hydrocarbons at room temperature.
US-9,399,660 N-substituted indenoisoquinolines and syntheses thereof
N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are...
US-9,399,659 Certain chemical entities, compositions, and methods
Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
US-9,399,658 Purification of triphosphorylated oligonucleotides using capture tags
The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and...
US-9,399,657 Chemiluminescent methods and reagents for analyte detection
The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate...
US-9,399,656 Compound, method for producing same, and use of same
A compound represented by the following Structural Formula (A) or a salt thereof. The compound or the salt thereof is suitably produced from a microorganism...
US-9,399,655 Catalytic glycosylation with designer thioglycoside and novel protecting groups for same and for synthesis of...
A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a...
US-9,399,654 Iridium-based complexes for ECL
The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g....
US-9,399,653 Methods and systems for preparing irreversible inhibitors of protein tyrosine phosphatases
Described herein are the preparation and use of novel bromo-phosphonomethylphenylalanine amino acid derivatives (BrPmp) and BrPmp-containing peptides as...
US-9,399,652 Synthetic route to pactamycin and pactamycin analogs
Methods and intermediates useful for making compounds of Formula (I) are described, including a general method of making an alpha, beta-diamino ketone by...
US-9,399,651 Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders
The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and...
US-9,399,650 Method for producing salts having monofluoro-tricyanoborate anions
The invention relates to a method for producing alkali metal salts having monofluoro-tricyanoborate anions from alkali metal tetrafluoroborates.
US-9,399,649 Compounds for treating spinal muscular atrophy
Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
US-9,399,648 Isothiazolopyridinones useful for the treatment of (inter alia) cystic fibrosis
The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane...
US-9,399,647 Proteasome activity modulating compounds
The present invention is directed to compounds having the Formula (I), (Ia) or (Ib), compositions thereof and methods for the treatment of a condition...
US-9,399,646 Estrogen receptor modulators and uses thereof
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds...
US-9,399,645 Inhibitors of HIV replication
Compounds of formula (I) and pharmaceutical compositions thereof: wherein A.sup.1 A.sup.2 and A.sup.3 are each independently selected from the group consisting...
US-9,399,644 [1,3] dioxolo [4,5-G] quinoline-6(5H)thione derivatives as inhibitors of the late SV40 factor (LSF) for use in...
The present invention relates generally to methods, compounds and/or compositions suitable for inhibiting, preventing and/or treating cancer, e.g....
US-9,399,643 Pharmaceutical intermediates and methods for preparing the same
A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally...
US-9,399,642 Pharmaceutical intermediates and methods for preparing the same
A pharmaceutical intermediate including a first indole moiety which is associated with an optionally carboxylated hexahydroazepino moiety, an optionally...
US-9,399,641 Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
A compound with the formula I wherein: R.sup.2 is of formula II where Q is selected from OH, SH and NR.sup.N, and R.sup.N is selected from H, methyl and ethyl,...
US-9,399,640 Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
The present invention relates to compounds represented by the general Formula I which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are...
US-9,399,639 Substituted azaindole compounds, salts, pharmaceutical compositions thereof and methods of use
The present invention provides substituted azaindole prodrugs, methods of making said prodrugs, pharmaceutical compositions of said prodrugs and methods of...
US-9,399,638 Substituted pyridine compounds as CRAC modulators
The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium...
US-9,399,637 Substituted heteroaryl compounds and methods of use
The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening...
US-9,399,636 Substituted dipyridylamines and uses thereof
The present invention provides for compounds of Formula I and various embodiments thereof, and compositions comprising compounds of Formula I and various...
US-9,399,635 Pyrazole derivative
Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): ...
US-9,399,634 Compositions and methods for the treatment of depression
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and...
US-9,399,633 Photoinitiators
The present invention provides novel photoinitiators for polyurethane formation, in which a photoinitiator moiety and a tertiary amine are incorporated into the...
US-9,399,632 Process for producing a solid oxidic material
The present invention relates to a process for producing a porous solid oxidic material from a hydrogel of the oxidic material and to the porous solid oxidic...
US-9,399,631 Polyphenol proteasome inhibitors, synthesis, and methods of use
The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity...
US-9,399,630 Process for preparing benzofuran-2-carboxamide derivatives
Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their...
US-9,399,629 Process for the manufacture of 3-oxo-tetrahydrofuran
This invention relates to a novel method for the preparation of 3-oxo-tetrahydrofuran comprising oxidizing 3-hydroxy-tetrahydrofuran in the presence of a...
US-9,399,628 1-aryl-1-hydroxy-2,3-diamino-propyl amines, 1-heteroaryl-1-hydroxy-2,3-diamino-propyl amines and related...
Compounds of the formula ##STR00001## where the variables have the meaning defined in the specification have analgesic and/or immunostimulant effect in mammals.
US-9,399,627 Substituted macrocyclic compounds having proteasome inhibitory activity
The disclosure provides for novel compounds which have proteasome inhibitory activity, pharmaceutical compositions made thereof, and methods of use thereof to...
US-9,399,626 2-thiopyrimidinones
Myeloperoxidase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, cardiovascular conditions.
US-9,399,625 Acridone compounds
(A1) A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical...
US-9,399,624 Process for preparing (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate
A process for preparation of (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate (Formula I), comprising reacting...
US-9,399,623 Quinoline derivatives and their use in neurodegenerative diseases
The present invention relates to quinoline compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment...
US-9,399,622 Nitroxide hydroxylamine and phenylenediamine combinations as polymerization inhibitors for ethylenically...
Polymerization inhibitor compositions are provided. The polymerization inhibitor compositions may include at least one hydroxylamine of a nitroxide and at least...
US-9,399,621 Process for preparing substituted indole derivatives
The present invention relates to a process for preparing substituted indole derivatives. More particularly, the invention refers to a new method to synthesize...
US-9,399,620 Process for preparing 3-methylsulfonylpropionitrile
The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final...
US-9,399,619 Sulfamoylbenzamide derivatives as antiviral agents against HBV infection
Pharmaceutical compositions of the invention comprise sulfamoylbenzamide derivative useful as pregenomic RNA encapsidation inhibitors, useful for the treatment...
US-9,399,618 High purity electrolytic sulfonic acid solutions
Disclosed is a solution for an electrochemical process, the solution containing a sulfonic acid and having a low concentration of sulfur compounds, either low...
US-9,399,617 Concentration of the urea solution in a process for the synthesis of urea
A process and a related plant for the synthesis of urea, where a solution (13) comprising urea is obtained in a synthesis section (10), said solution is treated...
US-9,399,616 Process for the manufacture of 4-aminobenzoamidine dihydrochloride
The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) ##STR00001## preferably the salts...
US-9,399,615 Catalyst and method for hydrogenation of 4,4'-methylenedianiline
Disclosed is a catalyst for hydrogenation of 4,4'-methylenedianiline (MDA), including a support, a magnesium-aluminum oxide layer covering the support, and a...
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