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Patent # Description
US-9,402,847 Combinations comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]py- ...
The present invention relates to a combination comprising (5)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]py- ...
US-9,402,846 Combination of inhibitor of B-Raf and inhibitor of AKT in the treatment of cancer
The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method...
US-9,402,845 Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of...
US-9,402,844 Methods of modulating drug plasma levels using erythrohydroxybupropion
This disclosure relates to methods administering erythrohydroxybupropion or a prodrug thereof in conjunction with dextromethorphan to a human being. Dosage...
US-9,402,843 Compositions and methods of using threohydroxybupropion for therapeutic purposes
This disclosure relates to methods administering threohydroxybupropion or a prodrug thereof in conjunction with dextromethorphan to a human being. Dosage forms,...
US-9,402,842 Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)--topoisomerase I (Top1) inhibitors
The invention described herein pertains to the synthesis and use of certain N-substituted indenoisoquinoline compounds which inhibit the activity Tyrosyl-DNA...
US-9,402,841 Pyridinyl and fused pyridinyl triazolone derivatives
Disclosed are compounds of Formula 1, ##STR00001## or pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined in...
US-9,402,840 Crystalline form of a quinolinone-carboxamide compound
The invention provides a crystalline hydrochloride salt of 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ...
US-9,402,839 Selective targeting agents for mitochondria
The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment...
US-9,402,838 Phenoxyethyl piperidine compounds
The present invention provides a compound of the Formula II: ##STR00001## wherein X is: ##STR00002## R.sup.1 is H, --CN, or F; R.sup.2 is H or methyl;...
US-9,402,837 Method for the treatment of neurological disorders by enhancing the activity of .beta.-glucocerebrosidase
Provided is a method of increasing the stability of wild-type .beta.-glucocerebrosidase. Also provided are methods of treating and/or preventing an individual...
US-9,402,836 Indoles
Herein are disclosed indoles of formula (I) ##STR00001## where the various groups are defined herein, and which are useful for treating cancer.
US-9,402,835 Animal treatments
Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of a...
US-9,402,834 Human therapeutic agents
Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all...
US-9,402,833 Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors
The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein...
US-9,402,832 Fused amino pyridine as HSP90 inhibitors
The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of...
US-9,402,831 Combination therapy of HSP90 inhibitors with BRAF inhibitors
A pharmaceutical combination comprising a BRAF inhibitor, and an Hsp90 inhibitor according to the following formulae (I): or a tautomer, or a pharmaceutically...
US-9,402,830 Methods of treating dyskinesia and related disorders
The present disclosure describes compounds and pharmaceutically acceptable salts thereof and compositions and formulations comprising the same that are useful...
US-9,402,829 Benzimidazole derivatives: preparation and pharmaceutical applications
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to...
US-9,402,828 Methods of targeting PTEN mutant diseases and compositions therefor
Provided herein are methods and compositions for treating a patient with cancer wherein the cancer is characterized by a PTEN gene mutation and/or a PI3K gene...
US-9,402,827 Treatment of gout
Sodium 2-(5-bromo-4-(4-cyclopropyl-naphthalen-1-yl)-4H-1,2,4-triazol-3-yl- thio)acetate is described. In addition, pharmaceutical compositions and uses such...
US-9,402,826 Neuronal pain pathway modulators
The present invention relates to compounds that may be used to inhibit activation of protein kinase G ("PKG"). It is based, at least in part, on the discovery...
US-9,402,825 Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic for administration...
Dry powder formulations for inhalation comprising a combination of an anticholinergic, a long-acting beta.sub.2-adrenoceptor agonist, and a corticosteroid are...
US-9,402,824 9,10-.alpha., .alpha.-OH-taxane analogs and methods for production thereof
Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds...
US-9,402,823 Ingenols for treating seborrheic keratosis
The invention provides ingenol compounds for treating seborrheic keratosis.
US-9,402,822 Fatty acid treatment for cardiac patients
A method of treating patients in need of treatment for a cardiac disorder has been found which comprises administering to the patient a seven carbon fatty acid...
US-9,402,821 Methods and pharmaceutical compositions for treatment of cystic fibrosis
The present invention relates to a method and compositions for the treatment of cystic fibrosis.
US-9,402,820 Use of pyruvate or succinate to enhance the efficacy of a hypoxia activated prodrug for the treatment of tumors
The identification of pO.sub.2 lowering agents as transient hypoxia-inducers is disclosed herein. Provided is a method of enhancing the efficacy of a...
US-9,402,819 Anti-HIV compound and preparation method and use thereof
The present invention relates to the technical field of chemically synthesized drugs, in particular to an anti-HIV drug or prodrug and preparation method and...
US-9,402,818 Use of amides of mono- and dicarboxylic acids in the treatment of renal diseases
A therapy for renal diseases, in particular renal diseases, which develop in diabetic patients or patients who have been subjected to a treatment with an...
US-9,402,817 Optical treatment methods
A treatment system and method includes use of a chemical facilitator to provide a result-effective event against one or more negative therapeutic effects...
US-9,402,816 Diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery
The instant invention provides for novel cationic lipids of Formula A that can be used in combination with other lipid components such as cholesterol and...
US-9,402,815 High drug load mesalazine sachet
The present invention is directed to a high drug formulation having desirable properties in terms of ease of manufacture and visual appearance as well as a...
US-9,402,814 Methods and devices for forming treatment agent carriers
A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form...
US-9,402,813 Pharmaceutical compositions
Pharmaceutical compositions are provided which comprise effective amounts of analgesic to treat a subject, including to reduce or eliminate an adverse effect...
US-9,402,812 Methods for the preparation of liposomes
Provided herein are methods for preparing liposomes and uses thereof. In certain embodiments, liposomes are prepared without using heat, organic solvents,...
US-9,402,811 Oromucosal liquid estradiol compositions
The present invention relates to low dose estradiol solutions for oromucosal administration suitable in replacement therapy or suppletion of low estradiol...
US-9,402,810 Pouch containing nicotine in free salt form
The invention relates to a product for oral delivery of nicotine containing a core comprising a powder of at least one free nicotine salt, at least one pH...
US-9,402,809 Snuff composition
Use of a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of...
US-9,402,808 Liquid oral composition of lanthanum salts
The present invention relates to liquid oral pharmaceutical compositions of lanthanum and its pharmaceutically acceptable salts thereof. The present invention...
US-9,402,807 Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug...
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many...
US-9,402,806 Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug...
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many...
US-9,402,805 Method of treating middle ear infections
Aqueous suspension formulations containing dexamethasone and ciprofloxacin are disclosed for the treatment of middle ear infections in human patients having an...
US-9,402,804 Injectable formulations of taxanes for cad treatment
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the...
US-9,402,803 Methods of wound care and treatment
Provided are electrokinetically-altered fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized...
US-9,402,802 Topical compositions comprising ascomycins
The present invention relates to a composition for topical administration comprising an ascomycin and a carrier vehicle comprising means to retain water in the...
US-9,402,801 Active ingredient combinations of magnolia bark extract and hyaluronic acid and the cosmetic and/or...
The invention relates to active ingredient combinations of magnolia bark extract and hyaluronic acid, cosmetic and/or dermatological preparations containing...
US-9,402,800 Cosmetic compositions comprising latex film formers
Disclosed are cosmetic compositions comprising latex film formers chosen from at least one random styrene acrylate copolymer or derivatives thereof, and at...
US-9,402,799 Sterilized composition comprising at least one hyaluronic acid and magnesium ascorbyl phosphate
The invention relates to a sterilized composition comprising at least one hyaluronic acid or biologically acceptable salt thereof, alone or in a mixture, and...
US-9,402,798 Carrageenan mixtures useful as cosmetic ingredients and hair styling gels comprising them
This invention provides a carrageenan mixture comprising about 60% to about 95% by weight of iota-carrageenans and about 5% to about 25% by weight of...
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