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Patent # Description
US-9,403,899 Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
The present invention provides methods for reducing the amidolytic and anti-complement activity (ACA) content of an immunoglobulin composition through the use...
US-9,403,898 Method for purifying albumin
An improved method for purifying albumin, a variant or fragment thereof, a fusion protein comprising albumin, a variant or fragment thereof, or a conjugate...
US-9,403,897 Proteinaceous protease inhibitor and protein solution and detergent composition containing it
An object of the present invention is to provide proteinaceous protease inhibitors with moderate inhibitory activity. A proteinaceous protease inhibitor of the...
US-9,403,896 Serpin-finger fusion polypeptide
The current invention comprises a fusion polypeptide comprising a serpin-finger polypeptide conjugated to a biologically active polypeptide optionally via a...
US-9,403,895 Production and delivery of a stable collagen
Improved methods are provided for the recombinant synthesis of collagen, particularly collagen VII, in host cell, and for therapeutic delivery of the same. The...
US-9,403,894 Glucagon analogues
The invention provides materials and methods for promoting weight loss or preventing weight gain without affecting glycemic control. In particular, the...
US-9,403,893 Avian colony stimulating factor 1 receptor binding proteins
The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit ...
US-9,403,892 Therapeutic TRAIL fusion protein and preparation and use thereof
This invention relates to the biotechnology area, and provides a kind of TRAIL chimeric protein, DNA sequence encoding this chimeric protein, vectors comprising...
US-9,403,891 Methods and compositions for modulating TNF/TNFR signaling
The present disclosure relates to methods and compositions for modulating TNF and TNFR signaling. In particular, the disclosure describes methods and...
US-9,403,890 HJURP peptides and vaccines including the same
Isolated peptides derived from SEQ ID NO: 50 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable...
US-9,403,889 Diagnostic lung cancer panel and methods for its use
Disclosed herein are novel diagnostic lung cancer panels and the use of these panels to diagnose, predict, and characterize lung cancer and to monitor or...
US-9,403,888 Compositions and methods for purifying Bax
Disclosed are compositions and methods for purifying a Bax protein. This abstract is intended as a scanning tool for purposes of searching in the particular art...
US-9,403,887 Endothelial cell-specific polynucleotides and use thereof
An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence of HIF-1alpha, the polypeptide...
US-9,403,886 Tumor antigen based on products of the tumor suppressor gene WT1
A tumor antigen that comprises, as an active ingredient, a product of the Wilms' tumor suppressor gene WT1 or a peptide composed of 7-30 contiguous amino acids...
US-9,403,885 Wnt compositions and therapeutic uses of such compositions
The invention provides novel Wnt polypeptides that have enhanced solubility and improved biologic drug-like properties, and polynucleotides encoding the Wnt...
US-9,403,884 Peptides useful as cell-penetrating peptides
A peptide having an amino acid sequence containing at least eight consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein....
US-9,403,883 Protein having affinity for immunoglobulin, and immunoglobulin-binding affinity ligand
An object of the present invention is to create a novel engineered Protein A ligand having better antibody dissociation properties in the presence of an acid...
US-9,403,882 Sulfation of Wnt pathway proteins
Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment...
US-9,403,881 Insecticidal proteins and methods of use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
US-9,403,880 Identification of a human gyrovirus and applications
The present invention relates to HGyV, a human gyrovirus related to the chicken anemia virus (CAV). The present invention also relates to a new proteins encoded...
US-9,403,879 Nucleic acid molecule encoding hepatitis B virus core protein and vaccine comprising the same
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequence of HBV core protein, as well as genetic constructs/vectors and...
US-9,403,878 Methods for producing virus particles with simplified glycosylation of surface proteins
Methods for producing virus particles with simplified glycosylation on structural or surface proteins, such as mono-glycosylated forms of influenza A virus,...
US-9,403,877 Peptide agents for cancer therapy
There is provided peptides for inhibiting growth of cancer cells, the peptides comprising the amino acid sequence RxKxKxxxxR wherein K and R are respectively...
US-9,403,876 Cyclic-GluR6 analogs, methods of treatment and use
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising ##STR00001## wherein R is a molecular transporter with or...
US-9,403,875 Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same
Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging,...
US-9,403,874 Peptides and use thereof
The present invention relates to novel peptides and use thereof and more specifically is directed to a peptide with anti-inflammatory effect, a polynucleotide...
US-9,403,873 Peptides targeting receptor activator of nuclear factor-.kappa.B (RANK) and their applications
The present invention relates to a polypeptide for use as a medicament in the treatment and/or prevention of a disease wherein the RANKL-RANK signaling pathway...
US-9,403,872 Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of...
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or...
US-9,403,871 Methods for treating pain by administering peptides derived from human basic proline-rich lacrimal protein
The invention relates to an in vitro method for prognosis, diagnosis or determination of the evolution of a condition involving an altered production of Basic...
US-9,403,870 Methods of phosvitin extraction and phosphopeptide preparation from egg yolk
The invention is directed to methods for extracting phosvitin from egg yolk involving contacting the egg yolk or egg yolk protein granules with a solution...
US-9,403,869 .alpha..sub.5.beta..sub.1 integrin binding RGD-lipopeptides with gene transfer activities
The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides high...
US-9,403,868 Crystalline tripeptide epoxy ketone protease inhibitors
The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions.
US-9,403,867 Methods of producing anamorelin hydrochloride having controlled chloride content
The present invention relates to particulate forms of anamorelin monohydrochloride or a composition comprising anamorelin monohydrochloride having controlled...
US-9,403,866 Compositions and methods for increasing telomerase activity
The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations....
US-9,403,865 Method of preparing oligomeric compounds using modified capping protocols
Provided herein are methods for the solid phase synthesis of oligomeric compounds wherein at least one of the capping steps has been modified. More...
US-9,403,864 Process for the synthesis of carbonucleoside and intermediates for use therein
Disclosed is a process for preparing a carbonucleoside of formula (1) and intermediates for use therein. The process involves the step of reacting a compound of...
US-9,403,863 Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of...
Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In certain embodiments, compounds and...
US-9,403,862 Reagent controlled stereoselective glycosylation
Provided are methods for the efficient stereoselective formation of glycosidic bonds, without recourse to prosthetic or directing groups.
US-9,403,861 Salen complexes with dianionic counterions
The present invention describes metal salen complexes having dianionic counterions. Such complexes can be readily precipitated and provide an economical method...
US-9,403,860 Metathesis catalysts containing onium groups
Disclosed herein is a general method for the preparation of complexes containing a quaternary onium group in an inert ligand. Some of these complexes may be...
US-9,403,859 Iridium-based complexes for ECL
The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g....
US-9,403,858 Platinum compounds, compositions, and uses thereof
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
US-9,403,857 Compositions and methods for the treatment of metabolic syndrome
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers,...
US-9,403,856 Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same
Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and...
US-9,403,855 Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of...
Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of...
US-9,403,854 Cross-metathesis reaction of functionalized and substituted olefins using group 8 transition metal carbene...
The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and...
US-9,403,853 Trimethylolpropane core, phosphonic acid terminated dendrimer and its preparation method
A trimethylolpropane core, phosphonic acid terminated dendrimer and its preparation method are provided, And a preparation method thereof comprises steps of...
US-9,403,852 Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical...
US-9,403,851 Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical...
US-9,403,850 Beta-lactamase inhibitors
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
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