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Patent # Description
US-9,403,849 Organic electroluminescent device and boric acid and borinic acid derivatives used therein
The present invention relates to the use of aromatic boronic acid or borinic acid derivatives in organic electronic devices, in particular electroluminescent...
US-9,403,848 Organometallic catalyst complex and polymerization method employing same
A novel class of organometallic complexes can be used as an ingredient of a catalyst system. The catalyst system can be used in polymerizations of ethylenically...
US-9,403,847 Substituted heteroaryl fused derivatives as P13K inhibitors
The present invention provides fused derivatives of Formula I: ##STR00001## that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in...
US-9,403,846 Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
The present invention provides compounds of formula I, ##STR00001## wherein the variables R.sup.1, R.sup.2, R.sup.5 and b are as defined in the specification....
US-9,403,845 Pesticidally active pyridyl- and pyrimidyl- substituted pyrazole derivatives
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms...
US-9,403,844 Rifaximin
Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to...
US-9,403,843 Cysteine protease inhibitors and uses thereof
The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides...
US-9,403,842 Prasugrel in non-crystalline form and pharmaceutical composition thereof
The present invention relates to prasugrel or a pharmaceutically compatible salt thereof, compositions that contain this active substance and pharmaceutical...
US-9,403,841 Phragamalin limonoids for the treatment of sexual dysfunction
The present invention relates to novel chemical compounds, to methods for synthesis of such compounds, and to the use of these novel compounds in the synthesis...
US-9,403,840 (Poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in...
The present invention relates to novel podophyllotoxin derivatives substituted in the 4-position by a substituted (poly)aminoalkylaminoacetamide chain, to their...
US-9,403,839 Pyran-spirocyclic piperidine amides as modulators of ion channels
The invention relates to pyran spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically...
US-9,403,838 Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions
The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing...
US-9,403,837 Stereoselective total synthesis of noribogaine
This invention relates generally to methods for synthesizing the non-addictive alkaloid noribogaine.
US-9,403,836 Organic compounds
1- or 2-substituted (6aR,9aS)-3-(phenylamino)-5-6a,7,8,9,9a-hexahydro-5-methyl-cyclopent[4,5]- imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H or, 2H)-one compounds...
US-9,403,835 Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators
The present invention provides compounds of Formula (I) as M1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic...
US-9,403,834 Pyrrolotriazines as potassium ion channel inhibitors
A compound of formula (I), wherein A, R.sup.1, R.sup.3, and R.sup.24 are described herein. The compounds are useful as inhibitors of potassium channel function...
US-9,403,833 Carboxamide derivatives
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or co-crystal thereof; ##STR00001## a method for manufacturing...
US-9,403,832 Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: ##STR00001## are disclosed, wherein R.sub.1, R.sub.2 and R.sub.3 are defined herein. Compositions...
US-9,403,831 Triazolopyrazine derivative and use thereof
The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing...
US-9,403,830 Inhibitors of leukotriene production
The present invention relates to compounds of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein A.sup.1, A.sup.2, L.sup.1 and B...
US-9,403,829 Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- ...
Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid...
US-9,403,828 Small-molecule Hsp90 inhibitors
Purine scaffold Hsp90 inhibitors are useful in therapeutic applications and as radioimaging ligands.
US-9,403,827 Substituted purinone compounds
The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for...
US-9,403,826 Compositions and methods for the treatment of inflammatory disorders
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and...
US-9,403,825 Compound, solar cell module, and photovoltaic power generation device
This compound is represented by the following general formula (IA) or (IB) (in the formula, R.sup.1 and R.sup.2 are each independently a hydrogen atom, an alkyl...
US-9,403,824 Pyridonemorphinan analogs and biological activity on opioid receptors
The application is directed to compounds of Formula I-A ##STR00001## and pharmaceutically acceptable salts and solvates thereof, wherein , R.sup.1a-R.sup.3a,...
US-9,403,823 Protein kinase inhibitors
The present invention relates to compounds of the following formula (I) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers,...
US-9,403,822 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases...
US-9,403,821 Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound
A method for making the compound ##STR00001## is set forth utilizing the starting material ##STR00002##
US-9,403,820 Kinase inhibitor polymorphs
Polymorphs of chemical compounds that modulate kinase activity, including PI3K activity, and chemical compounds, pharmaceutical compositions, and methods of...
US-9,403,819 Apoptosis signal-regulating kinase 1 inhibitors
The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula ##STR00001## wherein the variables are as...
US-9,403,818 Antimicrobial 4-oxoquinolizines
This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or...
US-9,403,817 Methods and compositions for preparing noribogaine from voacangine
Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.
US-9,403,816 Phenyl linked quinolinyl modulators of ROR.gamma.t
The present invention comprises compounds of Formula I. ##STR00001## wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and...
US-9,403,815 Compounds and uses thereof in modulating levels of various amyloid beta peptide alloforms
The invention provides a novel compound having a structure corresponding to Formula (I): (A)-(B)-(C)-(D) (I) or a pharmaceutically acceptable salt or prodrug...
US-9,403,814 Crystalline forms of dihydropyrimidine derivatives
The present invention relates to crystalline forms of dihydropyrimidine derivatives, and pharmaceutical compositions comprising the crystalline forms disclosed...
US-9,403,813 Azetidine amide derivatives as orexin receptor antagonists
The present invention relates to azetidine amide derivatives derivatives of formula (I) ##STR00001## wherein rings A.sub.1 A.sub.2 and A.sub.3 are as...
US-9,403,812 Triazole derivatives as Wnt signaling pathway inhibitors
The present invention relates to compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to...
US-9,403,811 Crystalline forms of azilsartan medoxomil potassium and preparation and uses thereof
The present invention relates to the field of pharmaceutical chemistry. Disclosed herein is a crystalline form of azilsartan medoxomil potassium, which is...
US-9,403,810 Carboxamide derivatives
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; ##STR00001## a method for manufacturing the compounds...
US-9,403,809 Synthesis of raltegravir
The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from...
US-9,403,808 Pyrazine derivatives
The invention relates to a compound of formula (I) ##STR00001## wherein R.sup.1 to R.sup.4 are defined as in the description and in the claims. The compound...
US-9,403,807 Mineralocorticoid receptor antagonists
The present invention is directed to compounds of the Formula I ##STR00001## as well as pharmaceutically acceptable salts thereof, that are useful for treating...
US-9,403,806 Cognition enhancing compounds and compositions, methods of making, and methods of treating
The invention relates generally to muscarinic agonists, which are useful for stimulating muscarine receptors, and treating cognitive disorders. Included among...
US-9,403,805 Antiviral compounds
The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical...
US-9,403,804 Inhibitors of c-fms kinase
The invention is directed to compounds of Formula I: ##STR00001## wherein Z, X, J, R.sup.2 and W are set forth in the specification, as well as solvates,...
US-9,403,803 Indole-3-carboxamides as kinase inhibitors
This invention is directed to a compound of Formula I ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
US-9,403,802 Heterocyclic compound and use therefor
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or...
US-9,403,801 Substituted heteroaryl compounds and methods of use
The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening...
US-9,403,800 Compounds for inhibition of cancer cell proliferation
Methods and small molecule compounds for inhibition of cancer cell proliferation are provided. One example of a class of compounds that may be used is...
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