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Patent # Description
US-9,403,799 Pyrimidinyl-pyridazinone derivatives for treating a disease which is influenced by inhibition of met kinase
Compounds selected from the group according to claim 1 are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the...
US-9,403,798 Triazinone compound and T-type calcium channel inhibitor
There is provided a novel triazinone compound that has an excellent T-type voltage-dependent calcium channel inhibitory activity and is specifically useful for...
US-9,403,797 5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
US-9,403,796 Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent...
The present invention relates to novel amidomethyl-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the...
US-9,403,795 Carbazole-based compound and organic light-emitting diode comprising the same
A carbazole-based compound of Formula 1 and an organic light-emitting diode including the same. The carbazole-based compound represented by Formula 1 has a...
US-9,403,794 Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to methods for labeling, imaging...
US-9,403,793 Compositions and methods for the treatment of moderate to severe pain
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and...
US-9,403,792 Methods of using pyruvate kinase activators
Described herein are compounds that activate pyruvate kinase, for use in a method for increasing lifetime of the red blood cells, for regulating ...
US-9,403,791 Coumarin derivatives for cancer therapy
The disclosure provides methods and compositions for treating and preventing cancer using 6-substituted coumarin derivatives. The coumarin derivatives of the...
US-9,403,790 Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme...
US-9,403,789 Benzofuran-containing amino acid inhibitors of cytochrome P450
Benzofuran-containing amino acid compounds are provided that are potent inhibitors of cytochrome P450 (CYP) enzymes. The compounds have the general structure ...
US-9,403,788 Process for the production of acid anhydrides from epoxides
A method of making acid anhydrides from epoxide and carbon monoxide feedstocks is presented. In various aspects, the method includes steps of reacting the...
US-9,403,787 Method for producing 2-furaldehyde
An object of the present invention is to provide a method for suppressing the corrosion of a reactor and reducing waste in the production of 2-furaldehyde from...
US-9,403,786 Anti-inflammatory compounds
New clerodane compounds isolated from plant material from Dodonaea polyandra are disclosed. The compounds have anti-inflammatory activity. Pharmaceutical and...
US-9,403,785 Process for preparing amorphous cabazitaxel
The present invention provides a non-solvated amorphous form of (2.alpha.,5.beta.,7.beta.,10.beta.,13.alpha.)-4-acetoxy-13-({(2R,3S)-3[ (tert-butoxy carbonyl) ...
US-9,403,784 Fumarate compounds, pharmaceutical compositions thereof, and methods of use
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for...
US-9,403,783 Methods for producing viloxazine salts and novel polymorphs thereof
Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction...
US-9,403,782 Fused heterocyclic compounds as ion channel modulators
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including...
US-9,403,781 Crystalline 1H-1,2,3-triazol-5-ylidenes
The present invention provides novel and stable crystalline 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes. The present...
US-9,403,780 Pyridine- or pyrazine-containing compounds
Described herein are selective bis-alkynyl pyrazines, bis-alkynyl pyridines, bispyridine substituted ellagic acid derivatives, and pyridine-substituted coumarin...
US-9,403,779 Combinations of histone deacetylase inhibitors and either Her2 inhibitors or PI3K inhibitors
The invention relates to combinations comprising an HDAC inhibitor and a Her2 inhibitor for the treatment of breast cancer in a subject in need thereof. The...
US-9,403,778 Agents that prevent or repair skin damage
The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides dermatological compositions comprising a...
US-9,403,777 Inhibitors of the influenza A virus M2 proton channel
Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are...
US-9,403,776 Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine,...
The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine...
US-9,403,775 AZA spiro alkane derivatives as inhibitors of metalloproteases
The present invention provides a compound of Formula I or Formula II: ##STR00001## enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically...
US-9,403,774 Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
The present invention provides compounds of Formula (I): (Formula (I)) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables...
US-9,403,773 Quinolone compound and pharmaceutical composition
The present invention provides a quinolone compound represented by General Formula (1) ##STR00001## or a salt thereof, wherein R.sub.1 represents a hydrogen...
US-9,403,772 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tol- ...
Compounds and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK.sub.1) receptor, based on ...
US-9,403,771 Fused heterocyclic compound
There is provided a compound having an excellent controlling effect on pests represented by the formula (1): ##STR00001## wherein, A.sup.1 represents...
US-9,403,770 Process for preparing fexofenadine
A process for preparing fexofenadine is described, which provides for the hydrolysis of ...
US-9,403,769 Small molecule inhibitors of PFKFB3 and glycolytic flux and their methods of use as anti-cancer therapeutics
Small molecule inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) having the following formula: Formula (1) are provided herein. Also...
US-9,403,768 Indolines
Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as described in...
US-9,403,767 Substituted 4-aminocyclohexane derivatives
The invention relates to compounds that have an affinity to the .mu.-opioid receptor and the ORL 1-receptor, methods for their production, medications...
US-9,403,766 Intermediates for producing NEP inhibitors or prodrugs thereof
The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ...
US-9,403,765 Retinal derivatives and methods for the use thereof for the treatment of visual disorders
Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
US-9,403,764 Method of production of a methionine salt
A method for production of a methionine salt in a reactive rectification column containing a weir having a height of 100 mm or more is provided.
US-9,403,763 CD4-mimetic inhibitors of HIV-1 entry and methods of use thereof
Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described...
US-9,403,762 Reaction products of guanidine compounds or salts thereof, polyepoxides and polyhalogens
Reaction products of guanidine compounds or salts thereof, polyepoxide compounds and polyhalogen compounds may be used as levelers in metal electroplating...
US-9,403,761 Aminocarbonylcarbamate compounds
The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake...
US-9,403,760 Compounds
Disclosed are compounds of the general formula I and II (as further defined herein) are useful in the production of inhibitors of sphingolipid synthesis the...
US-9,403,759 Water feed methods to control MW distribution and byproducts of the carbamylation of urea
The present invention provides methods for making a polycarbamate by feeding a) a urea in fluid form into a reaction medium containing b) an alkyd polyol, such...
US-9,403,758 Antibacterial agents
Antibacterial compounds of formula (I) are provided: ##STR00001## as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical...
US-9,403,757 Preparation of intermediates of X-ray contrast agents
The present invention relates to a process for the preparation of iodinated X-ray contrast agents and in particular to key intermediates thereof. It...
US-9,403,756 N-phenyl anthranilic acid derivatives and uses thereof
Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central...
US-9,403,755 Isometheptene isomer
The invention relates to a purified Isometheptene compound comprising the structure according to Formula (I), ##STR00001## or a hydrochloride, or a...
US-9,403,754 Process for hydrogenating aromatic di- and polyamines
A catalytic process for hydrogenating aromatic di- and polyamines with the aid of a selected catalyst system is provided, which comprises a mixture of a first...
US-9,403,753 Dual site catalyst for mild, selective nitrile reduction
A ruthenium bis(pyrazolyl)borate scaffold that enables cooperative reduction reactivity in which boron and ruthenium centers work in concert to effect selective...
US-9,403,752 Processes for preparing estolide base oils and oligomeric compounds that include cross metathesis
Provided herein are estolide base oils and oligomeric compounds prepared from processes that include cross metathesis. Exemplary processes include the...
US-9,403,751 Liquid-liquid extraction process for the production of acrylic esters
The invention relates to a liquid-liquid extraction process, comprising: the provision of a main input liquid stream, comprising at least one compound of...
US-9,403,750 Method for producing 2-octyl acrylate by direct esterification
The invention relates to a process for continuously producing 2-octyl acrylate by reacting acrylic acid and 2-octanol in the presence of a sulfonic acid...
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