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Methods for predicting survival in metastatic melanoma patients
Cellular and genetic signatures and methods of using same for subcategorizing stage III melanoma tumors are described herein. The signatures and methods are...
Biomarkers for diagnosing ischemia
The present invention provides methods and compositions for diagnosing and predicting the occurrence of ischemia. For example, the present invention provides...
Cystic fibrosis transmembrane conductance regulator gene mutations
The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are...
Compositions, methods, and systems for inferring bovine breed
Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for identifying breed, or line and breed, or line composition of a bovine...
Methods and systems for processing polynucleotides
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a...
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterized in that the cleavable...
Compostions and methods of nucleic acid-targeting nucleic acids
This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
Compound for sequencing by synthesis
The present invention provides deoxynucleoside tri- or tetraphosphate comprising a 3' nitrate and a detectable label covalently bound to the oxygen atom of an...
Methods and kits for nucleic acid sequencing
Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic...
Methods and reagents for reducing non-specific amplification
The present invention provides reagents for use in the amplification of nucleic acids. Amplification carried out using oligonucleotides containing modified...
Compositions, kits and methods for synthesis and/or detection of nucleic
A composition comprising a thermostable DNA polymerase; and a PCR inhibitor blocking agent, wherein the PCR inhibitor blocking agent is present in an amount...
DNA amplification and sequencing using DNA molecules generated by random
The present invention is directed to methods to prepare a DNA molecule or a plurality of DNA molecules by random fragmentation. In some embodiments, the present...
Chemically-enhanced primer compositions, methods and kits
A composition is provided comprising a negatively charged group, an oligonucleotide sequence and at least none or one nuclease-resistant linkage group to form a...
Method and system for decontaminating materials
Methods, systems, and devices for decontaminating materials containing biological or biologically derived materials, such as microorganisms or DNA products, are...
Stem accelerated isothermal nucleic acid amplification technology
The invention is in the field of nucleic acid amplification, hi particular, methods are described which utilize stem primers that improve the rapid and specific...
Methods of preventing non-specific reactions of nucleotide sequences
Disclosed herein are methods of nucleic acid amplification, including methods of preventing non-specific reaction of a nucleotide sequence with a DNA modifying...
Method and kit for discriminating between breast cancer and benign breast
A method and kit are related to discriminating between breast cancer and benign breast disease by the determination of the expression level of at least one...
Methods of using FET labeled oligonucleotides that include a 3'.fwdarw.5'
exonuclease resistant quencher domain...
Methods and compositions are provided for detecting a primer extension product in a reaction mixture. In the subject methods, a primer extension reaction is...
Methods and compositions related to nucleic acid binding assays
Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These...
Dissolvable films and methods including the same
A method includes providing a container, introducing a substance into the container, and introducing a readily dissolvable film into the container such that the...
A modified pyrroloquinoline quinone glucose dehydrogenase that exhibits a high selectivity for glucose is provided. A modified pyrroloquinoline quinone glucose...
Methods and kits for detection of O-GlcNAc and N-GlcNAc modification of
peptides and proteins
Methods and kits for detecting the presence of GlcNAc modification of a peptide or protein. The steps of detection may include combining the peptide or protein...
Phosphatase coupled glycosyltransferase assay
A kit for detecting or measuring glycosyltransferase activity including a first reagent comprising a phosphatase and a second reagent comprising a free...
Method and unit for preparing a sample for the microbiological analysis of
The preparation unit comprises a body (2) within which are fixed a first (3) and a second (4) membrane, said first membrane (3) having a first predetermined...
Biological sterilization indicator system and method
A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a...
Diagnostic method for the determination of Helicobacter pylori
The present invention relates to a diagnostic method for the determination of Helicobacter pylori in a tissue biopsy comprising the step of incubating a tissue...
Biological particle analyzer and method of analyzing biological particles
A biological particle analyzer is disclosed and includes a microchannel including an end coupled to a first drive electrode, another end coupled to a second...
A method for producing from host cells a heterologous polypeptide or protein comprising at least one cysteine residue in a reduced state. The method cultured...
Method for producing proteins
This invention relates to a method for producing a protein of interest, comprising introducing an expression vector which comprises a gene fragment comprising a...
Process for microbial production of a valuable compound
The present invention relates to a process for the production of a valuable compound by cultivation of a microorganism comprising cultivating the microorganism...
DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
Template switch-based methods for producing a product nucleic acid
Provided are methods of producing a product nucleic acid. The methods include combining a template deoxyribonucleic acid (DNA), a polymerase, a template switch...
Isothermal amplification using oligocation-conjugated primer sequences
Provided herein are methods and kits for isothermal nucleic acid amplifications that use an oligocation-oligonucleotide conjugate primer for amplifying a target...
Non-thermal cycling for polymerase chain reaction
Techniques, systems, and devices are disclosed for non-thermal cycling of polymerase chain reaction (PCR). In one aspect, a method for cycling PCR includes...
Methods of in vitro protein synthesis
Improved methods are provided in vitro synthesis of biological molecules, providing for improved yields, lowered costs, and enhanced utility. Improved yield and...
Process for producing chiral 1- substituted 2-piperidinols employing
The present invention relates to an enantioselective enzymatic process for the preparation of an optically active 3-hydroxypiperidinecarboxylic acid derivative.
Biorefinery system, methods and compositions thereof
The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C.sub.1 metabolizing microorganism reactor...
Cells or plants producing polylactate or its copolymers and uses thereof
The present invention relates to cells or plants that can produce polylactate or its copolymers and to a method for preparing polylactate or its copolymers...
Alcohol dehydrogenases (ADH) useful for fermentive production of lower
The invention relates to suitable candidate alcohol dehydrogenase (ADH) enzymes for production of lower alkyl alcohols including isobutanol. The invention also...
Polypeptides having cellulolytic enhancing activity and nucleic acids
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
Biosynthesis pathway for prenol in a recombinant microorganism
The present invention concerns a method for the biological preparation of prenol comprising culturing a microorganism genetically modified for the bioproduction...
Promoter-regulated differentiation-dependent self-deleting cassette
Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human...
Embodiments of the present invention comprise altering the biosynthesis and accumulation of sucrose in legumes by transforming the plants with the sucrose...
Soybean seed and oil compositions and methods of making same
Methods for obtaining soybean plants that produce seed with low linolenic acid levels and moderately increased oleic levels are disclosed. Also disclosed are...
Plant SNF1-related protein kinase gene
The present invention relates to the isolation, purification, characterization and use of the plant Snf1-related protein kinase (SnRK) gene and genetic...
Chimeric promoters capable of mediating gene expression in plants upon
pathogen infection and uses thereof
Described are synthetic promoters capable of mediating gene expression in plants upon pathogen infection. Furthermore, recombinant genes and vectors comprising...
Genetically modified yeast species, and fermentation processes using
genetically modified yeast
Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment...
Systems and methods for the secretion of recombinant proteins in gram
Disclosed herein are systems and methods for producing recombinant proteins utilizing mutant E. coli strains containing expression vectors carrying nucleic...
Aptamers to PDGF and VEGF and their use in treating PDGF and VEGF mediated
Aptamers that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided....