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Recombinant non-pathogenic marek's disease virus constructs encoding
infectious laryngotracheitis virus and...
Recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus and Newcastle Disease...
Viral vectors with modified transduction profiles and methods of making
and using the same
The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the...
Peptide-compound cyclization method
An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with...
Integrin targeted synthetic ligands for diagnostic and therapeutic
The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic...
Linker peptides and polypeptides comprising same
The invention is based, at least in part, on the finding that linker peptides which lack the amino acid sequence GSG reduce or eliminate the addition of...
Activation of sodium potassium ATPase
Activation sites on the alpha subunit of sodium potassium ATPase have been discovered. It has also been discovered that certain antibodies that bind to the...
Growth hormone releasing peptides
Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: ...
Method for producing a recombinant peptide and resultant peptide
The invention relates to peptides with the following general formula: A-Thr-Lys-Pro-B-C-D-X, where: A--0, Met, Met (O), Thr, Ala, His, Phe, Lys, Gly B--0, Gly,...
Peptide manufacturing process
A process for the manufacture of peptide Omiganan in solution phase. Novel intermediates in the process for the manufacture of Omiganan and processes for the...
Combinatorial synthesis of libraries of macrocyclic compounds useful in
A library of macrocyclic compounds of the formula (I) ##STR00001## where part (A) is a ##STR00002## bivalent radical, a --(CH.sub.2).sub.y-- bivalent...
Compositions and methods for inhibiting proteases
In particular, in alternative embodiments, the invention provides pharmaceutical compounds and formulations comprising a family of epoxyketone compounds, which...
Hepatitis C virus inhibitors
Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit...
Methods for production of proteins
The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a...
5' triphosphate oligonucleotide with blunt end and uses thereof
The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells...
Preparation process of erythromycin thiocyanate
Disclosed herein is a method or process for preparing erythromycin thiocyanate, which belongs to the pharmaceutical field. Also disclosed herein is a method of...
Quantification method for remaining liver function and novel liver
receptor imaging agent
A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop...
Tungsten oxo alkylidene complexes for Zselective olefin metathesis
The current application describes tungsten oxo alkylidene complexes for olefin metathesis.
Family of analogues and NADP+ or NADPH, their preparation and their
application in therapeutics
A new family of analogues of NADP+ or NADPH, their preparation and their application in therapeutics.
Preparation of graphitic C3N3P material
A new graphitic material has the empirical formula C.sub.3N.sub.3P and comprises triazine rings bound together by phosphorus atoms, and/or other 5- or...
Control of N-(phosphonomethyl)iminodiacetic acid conversion in manufacture
This invention relates to the preparation of N-(phosphonomethyl)glycine ("glyphosate") from N-(phosphonomethyl)iminodiacetic acid ("PMIDA"), and more...
Cyclohexenyl nucleic acids analogs
The present disclosure describes cyclohexenyl nucleic acid analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More...
Synthetic blend F-POSS compositions formed from multiple feedstock
The present disclosure relates, in exemplary embodiments, to compositions of matter comprising synthetic blends of at least two feedstocks that produce a...
Compounds useful as a photoinitiator and/or photosensitizer represented by the following formula (I): ##STR00001## wherein R.sup.1 and R.sup.2 each...
The present invention relates to a compound according to formula I ##STR00001## wherein R.sub.1 represents hydrogen, R.sub.2 represents hydroxyl and R.sub.3...
Easily synthesizable, spontaneously water-soluble, essentially VOC-free,
The invention relates to a composition and to a process for producing the composition comprising essentially water-soluble (meth)acrylamido-functional...
(Meth)allylsilane compound, silane coupling agent therefor, and functional
material using same
A (meth)allylsilane compound chemically bonded to various alcohol derivatives including polyol derivatives such as saccharides, is raw material used to cause a...
Aggregation induced emission active cytophilic fluorescent bioprobes for
long-term cell tracking
Fluorescent bioprobes comprising luminogen formed nanoparticles comprising luminogens with aggregation-induced emission (AIE) properties, which can be used for...
Super lewis acidic borate esters as 18F-labeled PET probes
Compounds having a 1-bora-1-fluoro-2,6,7-trioxabicyclo[2.2.2]octane moiety wherein the fluorine is .sup.18F are described. Also described are reagents for...
Chiral 4-boronophenylalanine (BPA) derivative and method for producing
same, and method for producing...
Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing ...
Compounds containing hydrido-tricyano-borate anions
The present invention relates to intermediate compounds for the preparation of hydrido-tricyano-borate anions, their preparation and their uses.
Selective glycosidase inhibitors and uses thereof
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions...
Drug-fluorophore complex for specific detection of tumor cells
Disclosed is a drug-fluorophore complex for specific detection of tumor cells. Specifically, the drug-fluorophore complex includes a tumor cell-targeting drug...
Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
2,4-disubstituted pyrimidines as kinase inhibitors
The present invention provides 2,4-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods...
Method for purifying emamectin benzoate and compositions comprising the
A purification process of emamectin benzoate and compositions comprising the same. The method for purifying emamectin benzoate comprising steps (a):...
Process for the manufacture of spirocyclic substituted
The present invention relates to a process for the manufacture of N-(2-((2R,12bS)-2'-oxo-1,3,4,6,7,12b-hexahydrospiro[benzofuro[2,3-a]quino- ...
Bridged bicyclic piperidine derivatives and methods of use thereof
The present invention relates to Bridged Bicyclic Piperidine Derivatives, compositions comprising a Bridged Bi-cyclic Piperidine Derivative, and methods of...
Heterocyclic amide derivatives as P2X7 receptor antagonists
The invention relates to heterocyclic amide derivatives of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, X and n are as defined in the...
Piperidinone carboxamide spirohydantoin CGRP receptor antagonists
The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or...
Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor
The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment...
Compounds of the formula I ##STR00001## in which R.sup.1 and R.sup.2 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed,...
Polymorphic forms of alcaftadine
The present invention relates to novel polymorphic forms of alcaftadine, processes of preparing novel polymorphic forms of alcaftadine and pharmaceutical...
Process for the preparation of sitagliptin phosphate
The present invention relates to a method for the preparation of sitagliptin phosphate and sitagliptin phosphate anhydrous of Formula (I') and monohydrate of...
Inhibitors of bruton's tyrosine kinase
Disclosed herein are compounds, including compounds having the structure of Formula (A), (B), (C), and (D), as described in further detail herein, that form...
Azepino[4,5-B]indoles and methods of use
This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described,...
Compounds are provided that act as potent antagonists of the CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating...
Dihydropyridone p1 as factor XIa inhibitors
The present invention provides compounds of Formula (X):(Formula (X), or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the...
The present invention relates to compounds of formula I ##STR00001## wherein R.sub.1, R.sub.4, Ar, W, X and Z are all as defined herein. The compounds of the...
Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of
hematopoietic stem cells
Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem...
Antibacterial compounds and methods for use
The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial...