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Patent # Description
US-9,409,904 Compounds and compositions for use in augmentation of glucose
The present invention is directed to compounds such as: formula wherein linker is independently selected from the group consisting of --S--, --S--S--,...
US-9,409,903 Benzyl substituted triazine derivatives and their therapeutical applications
The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.
US-9,409,902 Modulators of HEC1 activity and methods therefor
Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Especially preferred compounds disrupt Nek2/Hec1 binding and are...
US-9,409,901 Compositions and methods for treating or preventing diseases or disorders associated with misregulated EIF4E
Disclosed herein are compounds, compositions, formulations, kits and methods of treatment useful for treating or preventing one or more hyperproliferative...
US-9,409,900 Compound for increasing kinase active and application thereof
The compound of Formula (I), pharmaceutically acceptable salts thereof, solvates thereof, chelates thereof, non-covalent complexes thereof or produgs of...
US-9,409,899 Process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclo hexylmethanisoindol-1,3-dione and its...
The present invention discloses process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclohexylmethanisoindol-1,3-di- one and intermediates thereof.
US-9,409,898 Substituted pyrazole compounds as CRAC modulators
The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium...
US-9,409,897 Benzamide derivatives as modulators of the follicle stimulating hormone
Novel benzamide derivatives of formula (I) ##STR00001## wherein W.sup.1, W.sup.2, R.sup.1 to R.sup.10 and X have the meaning according to the claims, are...
US-9,409,896 Sustained release pharmaceutical compositions comprising an antibacterial agent
The present invention relates to carrier systems useful for pharmaceutical compositions. These carriers comprise an emulsifier, and also in further embodiments...
US-9,409,895 Autotaxin inhibitors
The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments...
US-9,409,894 Carbamates
The present invention relates to carbamates of formula (I), ##STR00001## wherein the variables are defined according to the description, as well as to a...
US-9,409,893 Heteroaryl derivatives and uses thereof
The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This...
US-9,409,892 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors
The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms,...
US-9,409,891 Solid forms of an antiviral compound
Crystalline solid forms and the amorphous form of the anti-HCV compound 5-(3,3-dimethylbutyn-1-yl)-3-[(cis-4-hydroxy-4-{[(3S)-tetrahydrofuran-3-y- ...
US-9,409,890 Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of...
US-9,409,889 Amino-substituted imidazopyridazines
The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I); in which A, R1, R2, R3, R4, R5 and n are as defined in...
US-9,409,888 Dimeric compounds
Disclosed are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein Z, X, Q and R.sup.1 are as described in this application, and...
US-9,409,887 Mutant-selective EGFR inhibitors and uses thereof
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
US-9,409,886 Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and...
US-9,409,884 5- or 6-substituted benzofuran-2-carboxamide compounds and methods for using them
The disclosure relates particularly to certain carboxamide, sulfonamide and amine compounds and pharmaceutical compositions thereof, and to methods of treating...
US-9,409,883 Materials for organic electroluminescent devices
The present invention relates to coordination compounds which are used in an electron-transport layer in electronic devices, to ligands, and to the use thereof...
US-9,409,882 Pyridine derivatives
The invention relates to a compound of formula (I) ##STR00001## wherein A.sup.1, A.sup.2 and R.sup.1 to R.sup.6 are defined as in the description and in the...
US-9,409,881 Herbicidally active 6'-phenyl-2,2'-bipyridine-3-carboxylic acid derivatives
There are described 6'-phenyl-2,2'-bipyridine-3-carboxylic acid derivatives of the general formula (I) as herbicides. ##STR00001## In this formula (I),...
US-9,409,880 Modulators of TLR3/dsRNA complex and uses thereof
The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex,...
US-9,409,879 Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as...
Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.
US-9,409,877 Process for the synthesis of 5-hydroxymethylfurfural from saccharides
This invention relates to a process for the synthesis of 5-hydroxymethylfurfural (HMF) from saccharides. In particular this invention relates to a process for...
US-9,409,876 Bradykinin receptor antagonists and pharmaceutical compositions containing them
The present invention relates to compounds represented by formula (I) ##STR00001## and pharmaceutically acceptable salts thereof that are antagonists of the...
US-9,409,875 Crystal modifications of elobixibat
The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-1,1-dioxido-5-phenyl-2,3,4,5-te- ...
US-9,409,874 Method for producing 1,4-benzoxazine compound
The present invention provides an industrially advantageous method for producing a 1,4-benzoxazine compound useful as a medicine while avoiding safety and...
US-9,409,873 CDKI pathway inhibitors and uses thereof
The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates...
US-9,409,872 Fumarate compounds, pharmaceutical compositions thereof, and methods of use
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for...
US-9,409,871 Pyridazinyl derivatives as SMO inhibitors
The present invention relates to compounds of formula I: ##STR00001## in which L, W, X, Y, Z, m, p, R1, R2, R3, R4 and R7 are defined in the Summary of the...
US-9,409,870 Compounds
Compounds of formula (I) described herein are imidazolone derivatives having human neutrophil elastase (HNE) inhibitory properties and are useful for the...
US-9,409,869 Hydrazinyl lipidoids and uses thereof
The present disclosure is directed to hydrazinyl lipidoids, formulations thereof further comprising at least one active agent, as well as methods of delivering...
US-9,409,868 Inhibitors of rho associated protein kinases (ROCK) and methods of use
Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are...
US-9,409,867 Ligands of the benzo[h]quinoline class and transition metal complexes containing them and use of said complexes...
A new class of ligands derived from benzo[h]quinoline are described and these ligands are used to prepare several novel transition metal complexes. The...
US-9,409,866 Pyridine-2-amides useful as CB2 agonists
The invention relates to a compound of formula (I) wherein R.sup.1 to R.sup.4 are defined as in the description and in the claims. The compound of formula (I)...
US-9,409,865 Modulators of methyl modifying enzymes, compositions and uses thereof
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
US-9,409,864 Sulfonamide TRPA1 receptor antagonists
The invention discloses compounds of Formula (I). The compounds of formula (I) are TRPA1 antagonists and are useful as active ingredients of pharmaceutical...
US-9,409,863 Process for preparing chloroamines
The present application relates to a process for preparing chloroamines which can be used as precursors for syntheses of fine chemicals and active ingredients...
US-9,409,862 Compositions for preventing and/or treating degenerative disorders of the central nervous system
The present invention provides novel compounds as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the...
US-9,409,861 Mercapto benzophenone compounds, compositions and preparation method thereof
The present invention provides a photocurable composition prepared using mercapto benzophenone compounds as key raw materials. The present invention aims to...
US-9,409,860 Cosmetic use of N-substituted sulfonyloxybenzylamines and related compounds
Cosmetic compositions comprising N-substituted sulfonyloxybenzylamines and methods of using such compositions to impart anti-aging benefits to the skin are...
US-9,409,859 Substituted diphenyl derivatives
Triazene-substituted diphenyl derivatives are suitable as chemotherapeutic agents for treating carcinomas in humans and animals.
US-9,409,858 Selective histone deactylase 6 inhibitors
Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula (I). Methods of making and using these inhibitors for the treatment of cancer,...
US-9,409,857 Agomelatine sulfuric acid complex, and preparation method and application thereof
The present invention relates to an Agomelatine sulfuric acid complex in formula (I) and the preparation method thereof (HX=H.sub.2SO.sub.4, RSO.sub.3H...
US-9,409,856 Estrogen receptor ligands and methods of use thereof
The present invention relates to a novel class of nuclear receptor binding agents (NRBAs). The NRBA compounds are applicable for use in the prevention and/or...
US-9,409,855 Asymmetric synthesis of (-)-venlafaxine using organocatalyst
The patent discloses an asymmetric synthesis of (-)-venlafaxine using an organocatalyst via a unified strategy employing organcatalytic Michael addition,...
US-9,409,854 Liquid phase nitration of aromatics using solid acid catalyst
The present invention discloses an improved process for the liquid phase nitration of aromatic compounds catalyzed by WO3 supported on mesoporous silica...
US-9,409,853 Polyglycerol partial esters, preparation and use thereof
Polyglycerol partial esters of a specific composition which are capable of solubilizing very hydrophobic, oil-soluble substances in aqueous solution are...
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