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Patent # Description
US-9,416,200 Process for the preparation of 1,3-butadiene and styrene copolymers and use thereof in vulcanizable elastomeric...
A process for the preparation of a 1,3-butadiene and styrene copolymer comprising the following steps: a) anionically polymerizing a blend comprising from 5% by...
US-9,416,199 Method for producing alkali cellulose
The present invention relates to a method for producing an alkali cellulose with suppressed decrease in the degree of polymerization as well as with small use...
US-9,416,198 Method for producing alkali cellulose
The present invention relates to a method for producing an alkali cellulose with suppressed decrease in the degree of polymerization as well as with small use...
US-9,416,197 Bispecific antibodies that neutralize both TNF-.alpha. and IL-6: novel therapeutic agent for autoimmune disease
The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one anti-TNF-.alpha. antibody or antigen-binding...
US-9,416,196 Composition for prophylaxis or treatment of vascular or cardiac valvular calcification comprising dipeptidyl...
There is provided a composition for prophylaxis or treatment of vascular or valvular calcification including a dipeptidylpeptidase-4 (DPP-4) inhibitor. The...
US-9,416,195 Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.
US-9,416,194 Glycan-interacting compounds
The present invention provides glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting...
US-9,416,193 Pharmaceutical composition for treatment and/or prevention of liver cancer
Provided is an antibody effective for treatment and/or prevention of liver cancer. A pharmaceutical composition for treatment and/or prevention of liver cancer...
US-9,416,192 Pharmaceutical composition for treatment and prevention of cancers
The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody...
US-9,416,191 Pharmaceutical composition for treatment and/or prevention of cancer
According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an...
US-9,416,190 Mesothelin antibodies and methods for eliciting potent antitumor activity
Described herein is the use of phage display antibody engineering technology and synthetic peptide screening to identify SD1 and SD2, human single-domain...
US-9,416,189 Anti-CXADR antibody
An object is to find a target molecule effective for cancer treatments and the like and to provide an antibody capable of specifically binding to the molecule,...
US-9,416,188 Molecules that bind CD180, compositions and methods of use
Disclosed herein are novel CD180 binding molecules, methods for their identification, and methods for their use.
US-9,416,187 CD-20 specific antibodies and methods of employing same
The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical...
US-9,416,186 Antigen presenting cell targeted anti-viral vaccines
The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen...
US-9,416,185 Humanized antibodies against TL1A
Disclosed are humanized antibodies that bind specifically to TNF superfamily member 15 (TNFSF15), also known as TL1A. Methods of making and using the anti-TL1A...
US-9,416,184 Method of treating pruritus with IL-31 monoclonal antibodies
The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing,...
US-9,416,183 Methods of treating inflammatory diseases using antibodies that bind both IL-17A and IL-17F
The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are...
US-9,416,182 Anti-TNF-anti-IL-17 bispecific antibodies
Bispecific antibodies are provided that specifically bind both Tumor Necrosis Factor alpha (TNF.alpha.) and Interleukin-17 (IL-17). The bispecific antibodies of...
US-9,416,181 Compositions for cell culture and methods of using the same
Supplementation of the bioflavonoids such as epigallocatechin gallate, rutin, naringin, or genistein into mammalian cell culture media are shown to be effective...
US-9,416,180 Precision medicine by targeting VEGF-A variants for treatment of diabetic macular edema and branch retinal vein...
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
US-9,416,179 PDGF receptor beta binding polypeptides
The present invention provides binding polypeptides (e.g., antibodies or fragments thereof) that specifically bind to a target antigen (e.g., a human antigen,...
US-9,416,178 Jagged-binding agents and uses thereof
The present invention relates to Jagged-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides...
US-9,416,177 Antibodies that specifically bind to DRG11-responsive (dragon) proteins
This invention features antibodies that specifically bind to a human Dragon family protein.
US-9,416,176 RBM3 protein in colorectal cancer prognostics
The present invention provides means, such as a method, for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second...
US-9,416,175 Variants of humanized immunomodulatory monoclonal antibodies
The present invention relates to humanized monoclonal antibodies, pharmaceutical compositions that include the same, and use thereof for the treatment of a...
US-9,416,174 Antibody specifically binding synovial microvasculature of arthritis patients
The present invention provides an antigen binding polypeptide which specifically targets the synovial microvasculature of arthritis patients and comprises one...
US-9,416,173 Peptide and conjugate vaccines for fungal infections
Several new peptides have been developed that show effectiveness as vaccines against candidiasis and other fungal diseases. A new conjugate vaccine of a...
US-9,416,172 Compositions and methods for treating and preventing Staphylococcus aureus infections
Antibodies having Fab regions that specifically bind to Staphylococcus aureus protein A are capable of mediating opsinization of Staphylococcus aureus bacteria...
US-9,416,171 Immunoglobulins and variants directed against pathogenic microbes
Anti-microbial monoclonal antibodies and variant antibodies having a heavy chain constant regions with at least one amino acid substitution are provided. Such...
US-9,416,170 Fibronectin binding domains with reduced immunogenicity
Fibronectin type III (.sup.10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes...
US-9,416,169 Humanized monoclonal antibodies and methods of use
The present invention comprises a humanized monoclonal antibody that binds to the chemokine receptor CCR4. This antibody is derived from Mab 1567 and recognizes...
US-9,416,168 IL-17R-ECD mutants and methods of using same
Provided are engineered soluble hIL-17RA receptors with high affinity to hIL-17 that inhibit downstream IL17A induced signaling events in cells. Also provided...
US-9,416,167 Stable liquid formulations of dimer VEGF antagonists
Formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided including a pre-lyophilized formulation, a...
US-9,416,166 CD44 splice variants in neurodegenerative diseases
There is provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable...
US-9,416,165 Methods of inhibiting viral replication and improving T cell function employing soluble Tim-3 inhibitors
The application relates to methods of treating a chronic viral infection, such as HIV (Human Immunodeficiency Virus), by modulating Tim-3 activity, whereby...
US-9,416,164 Method for the production of polypeptides
New methods for the production of recombinant polypeptides from inclusion bodies are disclosed. Modulation of the cell culture conditions positively affects the...
US-9,416,163 Synthetic oligopeptides designed from mite cysteine proteases and methods for the production of polyclonal IgY...
The invention refers to the design, synthesis and evaluation of 6 synthetic oligopeptides, that have not been previously described, designed from the T and B...
US-9,416,162 Peptides having reduced toxicity that stimulate cholesterol efflux
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length...
US-9,416,161 Nucleic acids encoding peptides for treating wounds, anti-angiogenic compounds and uses thereof
The present disclosure relates to protein and peptide chemistry. More particularly, it relates to compounds, compositions and uses thereof for promoting and...
US-9,416,160 Macromolecular complex of bacterial origin and use of said macromolecular complex for preventing and treating...
A bacterial macromolecular complex produced by bacteria belonging to the Bifidobacterium longum strain deposited according to the treaty of Budapest under...
US-9,416,159 Method of producing a positive inotropic effect using an antibody that binds sodium potassium atpase
Activation sites on the alpha subunit of sodium potassium ATPase have been discovered. It has also been discovered that certain antibodies that bind to the...
US-9,416,158 Cytokine receptor peptides, compositions thereof and methods thereof
The invention provides a pharmaceutical composition including a peptide comprising at least a portion of a chemokine receptor or a G-protein coupled receptor...
US-9,416,157 Peptides for treating and preventing immune-related disorders, including treating and preventing infection by...
In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an...
US-9,416,156 Method of making biologically active alpha-beta peptides
Described is a method of fabricating biologically active, unnatural polypeptides. The method includes the steps of selecting a biologically active polypeptide...
US-9,416,155 Direct sensing of molecular species by polyfluors on a DNA backbone
Nucleoside analogs are provided; and fluorescent sensors comprising the nucleoside analogs. The sensors comprise multiple chromophores built on a DNA backbone,...
US-9,416,154 5'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
The present invention relates to 5'-Substituted Nucleoside Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein X, Y, Z,...
US-9,416,153 Fluorescent dyes
Provided are various compounds comprising the formula ##STR00001## Also provided are fluorescent dyes comprising the above compound. Additionally, a...
US-9,416,152 Azacitidine process and polymorphs
The present invention relates to process for the preparation of azacitidine and its crystalline forms.
US-9,416,151 Use of glycyrrhetinic acid, glycyrrhizic acid and related compounds for prevention and/or treatment of...
The present invention pertains to novel uses of glycyrrhetinic acid (GA), glycyrrhizic acid (GLA) and related compounds for prevention and/or treatment of...
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