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Patent # Description
US-9,416,150 Iridium-based complexes for ECL
The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g....
US-9,416,149 Methods to modulate Rac1 import and to treat pulmonary fibrosis
The invention provides methods for treating fibrosis, as well as methods for modulating mitochondrial peroxide production in a cell, and methods for modulating...
US-9,416,148 Phosphorus compound and transition metal complex of the same
The present invention provides a compound represented by general formula (1) and a transition metal complex containing the compound as a ligand: ##STR00001## ...
US-9,416,147 Preparation of silazane compound
A silazane compound useful as synthesis intermediates for paint additives, polymer modifiers, pharmaceuticals and agricultural chemicals is efficiently prepared...
US-9,416,146 Boron-containing small molecules as anti-inflammatory agents
Compounds and methods of treating anti-inflammatory conditions are disclosed.
US-9,416,145 Compositions and methods for inhibiting activity of hypoxia-inducible transcription factor complex and its use...
Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and...
US-9,416,144 Benzoxazine oxazolidinone compound, preparation method and application thereof
Disclosed are a benzoxazine oxazolidinone compound shown by a general formula (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a...
US-9,416,143 Griseofulvin derivatives
The present invention relates to compounds of the following general formula (I), or to a pharmaceutically acceptable salt thereof, as well as to the uses...
US-9,416,142 Griseofulvin derivatives
The present invention relates to compounds of the following general formula (I), or to a pharmaceutically acceptable salt thereof, as well as to the uses...
US-9,416,141 Compounds and methods for preventing, treating and/or protecting against sensory hair cell death
Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair...
US-9,416,140 Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives...
Discloses is a process for preparation of a compound of formula 7, or a derivative thereof, wherein PG.sup.1 is an alcohol protecting group. Also, disclosed are...
US-9,416,139 Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof
A compound of formula (I) or a stereoisomer, a geometric isomer. a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt...
US-9,416,138 Benzyl sulfonamide compounds useful as MoGAT-2 inhibitors
The present invention provides compounds of Formula I. Wherein R1, L, and A are as described herein, or a pharmaceutical salt thereof, processes for preparing...
US-9,416,137 Morphan and morphinan analogues, and methods of use
The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising...
US-9,416,136 Pyrrolopyrimidine compounds and their uses
The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment...
US-9,416,135 Liver X receptor modulators
Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions...
US-9,416,134 Solid forms of 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyr- ...
Provided herein are formulations, processes, solid forms and methods of use relating to the Compound for formula 1: ##STR00001## having the name...
US-9,416,133 Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors
Compounds of the formula I in which R.sup.1, R.sup.2, R, X.sup.1, X.sup.2, X.sup.3, X.sup.4, n1, n2, n3 and n4 have the meanings indicated in claim 1, are...
US-9,416,132 Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or ...
US-9,416,131 Prophylactic agent and/or therapeutic agent for diffuse large B-cell lymphoma
To provide a medicament which shows more remarkable effect in treatment of activated B-cell like diffuse large B-cell lymphoma (ABC-CLBCL) than the existing Btk...
US-9,416,130 4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1 ...
Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
US-9,416,129 Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use
In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): (I) and tautomers and...
US-9,416,128 Fused heterocyclic compounds as ion channel modulators
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including...
US-9,416,127 Triazole carboxamides and uses thereof
The invention relates to compounds of formula ##STR00001## wherein R.sup.1 is phenyl or pyridinyl, optionally substituted by halogen, lower alkyl, lower...
US-9,416,126 Compounds inhibiting leucine-rich repeat kinase enzyme activity
The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in...
US-9,416,125 Substituted cycloalkenopyrazoles as BUB1 inhibitors for the treatment of cancer
Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or...
US-9,416,124 Substituted 2-alkyl-1-OXO-N-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinoline-4-carb- oxamides for...
In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl -1,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods...
US-9,416,123 Kinase modulators for the treatment of cancer
Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of...
US-9,416,122 High refractive (meth)acrylate derivative and method for preparing the same
Provided are a high refractive (meth)acrylate derivative and a method or preparing the same, and more particularly, a novel high refractive (meth)acrylate...
US-9,416,121 Compounds for the treatment of mycobacterial infections
The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: ##STR00001##
US-9,416,120 Benzofuran-2-sulfonamides pyridine derivatives as chemokine receptor modulators
The present invention relates to novel benzofuran-2-sulfonamide pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them...
US-9,416,119 Reduction of HMF ethers with metal catalyst
Methods of making reduced derivatives of hydroxymethyl furfural using metal catalysts are described. The derivatives may have tetrahydrofuran or furan nucleus...
US-9,416,118 Docosahexaenoyl ethanolamides
The invention describes novel mono or dihydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
US-9,416,117 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same
The invention provides 5-deuterium-enriched 2,4-thiazolidinediones (e.g., 5-[4-[2-(5-ethyl-2-pyridyl)-2-oxoethoxy]benzyl]-5-deutero-thiazolidine-2,- 4-dione),...
US-9,416,116 Method of preparation of metaxalone
The present invention relates to a method of preparation of metaxalone comprising reaction of triglycidyl isocyanurate (TGIC) with m-xylenol, characterized in...
US-9,416,115 Fused heterocyclic compounds as ion channel modulators
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including...
US-9,416,114 1,2,4-triazine derivatives for the treatment of viral infections
This invention relates to 1,2,4-triazine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections. ...
US-9,416,113 Formation of N-protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the...
US-9,416,112 2,4-pyrimidinediamine compounds and their uses
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical...
US-9,416,111 Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors
The invention provides certain substituted diazine and triazine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R.sup.1,...
US-9,416,110 Process for making hydroxylated cyclopentylpyrimidine compounds
The invention provides processes for preparing a compound of formula I and salts thereof, wherein R.sup.1 is defined herein, and compounds and intermediates of...
US-9,416,109 Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
US-9,416,108 Heterocyclic aspartyl protease inhibitors
Disclosed are compounds of the formula I ##STR00001## or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a...
US-9,416,107 Heterocyclic compound and organic light-emitting device including the same
A heterocyclic compound represented by Formula 1 below and an organic light-emitting device including the same: ##STR00001## wherein Formula 1 is defined as...
US-9,416,106 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
US-9,416,105 Process for preparation of saxagliptin and its hydrochloride salt
Described is an improved and industrially feasible process for the preparation of Saxagliptin or its hydrochloride salt. Also described are the novel...
US-9,416,104 Vitamin D receptor-coregulator inhibitors
Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting...
US-9,416,103 Use of the aminoalkylindole JWH-073-M4 and related compounds as neutral CB1 receptor antagonists for the...
Novel alkylindoles that bind tightly to cannabinoid receptors and are neutral antagonists for the cannabinoid 1 receptor and agonists for the cannabinoid 2...
US-9,416,102 (22E)-2-methylene-22-dehydro-1.alpha.,24,25-trihydroxy-19-nor-vitamin D.sub.3 analogs
Disclosed are (22E)-2-methylene-22-dehydro-1,24,25-trihydroxy-19-nor-vitamin D.sub.3 compounds, their biological activities, and various pharmaceutical uses ...
US-9,416,101 Methods and compositions useful in treating cancer and reducing WNT mediated effects in a cell
Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.
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