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Vaccine composition comprising complexed immunostimulatory nucleic acids
and antigens packaged with...
The present invention is directed to an inventive composition or vaccine composition comprising a) an adjuvant component comprising or consisting of at least...
Immunostimulatory combinations of TLR ligands and methods of use
The present invention provides immunostimulatory combinations of TLR ligands and therapeutic and/or prophylactic methods that include administering an...
Compositions for canine respiratory disease complex
Provided herein are compositions comprising a canine influenza virus and a canine respiratory coronavirus. They can further comprise Bordetella bronchiseptica,...
Live bacterial vaccines resistant to carbon dioxide (CO.sub.2), acidic pH
and/or osmolarity for viral infection...
Gram-negative bacterial mutants resistant stress conditions, including CO.sub.2, acid pH, and high osmolarity are provided, having reduced TNF-.alpha. induction...
Rapid responses to delayed booster immunisations
Booster immunization can lead to rapid induction of protective immunity against pathogens (e.g. .ltoreq.7 days after the booster dose). This rapid response...
Pathogenic phlebovirus isolates and compositions and methods of use
Described herein are the clinical and laboratory characteristics of two patients bitten by ticks and infected with a unique member of the genus Phlebovirus...
Methods to activate or block the HLA-E/Qa-1 restricted CD8+ T cell
regulatory pathway to treat immunological...
Methods are provided for inhibiting or enhancing down-regulation of an antigen-activated HLA-E.sup.+ T cell by an HLA-E-restricted CD8.sup.+ T cell comprising...
Alpha 1-proteinase inhibitor for delaying the onset or progression of
An alpha.sub.1-proteinase inhibitor delays the onset or progression of pulmonary exacerbations. In addition, methods delay the onset or diminish the progression...
Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and
methods of using the same
Compositions of matter and methods for making, storing and administering artificial blood substitutes. Artificial blood substitutes may have oxygen carriers...
Ingestible formulations for transient, noninvasive reduction of gastric
Provided are ingestible polymeric formulations and oral dosage forms for the reduction of gastric volume in the treatment of overweight and obese patients. The...
The present invention relates to compositions, methods and kits for delivery of active agents (X) to cells or tissues that express proteoglycans. More...
Long-acting interferon beta formulation comprising an immunoglobulin
The present invention relates to a long-acting interferon beta formulation having improved in vivo duration and stability, comprising an interferon beta...
Therapy for influenza like illness
An agent selected from: (a) interferon-.beta. (IFN-.beta.); (b) an agent that increases IFN-.beta. expression; or (c) a polynucleotide which is capable of...
Methods and materials for reducing the severity of viral infections
This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For...
Therapeutic modulation of ocular surface lubrication
Provided herein are ophthalmically acceptable pharmaceutical compositions comprising PRG4 or lubricant fragments and a PRG4 inducing compound. The PRG4 inducing...
Compstatin analogs for treatment of neuropathic pain
In some aspects, the present invention provides methods of treating a subject in need of treatment for neuropathic pain, the method comprising administering a...
Therapy and kit for the prevention and treatment of cystic fibrosis
A combination therapy and kit including an agent that inhibit the interaction between CAL and mutant CFTR proteins, in combination with a CFTR corrector, CFTR...
Treatment of klebsiella pneumoniae with liposomally formulated glutathione
The composition of the invention, liposomal glutathione, has been recently shown to have utility for having an antibiotic like effect on Klebsiella pneumonia...
Tripeptide boronic acid or boronic ester, preparative method and use
The present invention discloses proteasome inhibitors of tripeptide boronic acids or boronic esters represented by Formula (I), preparative method and use...
Compositions comprising Lilium siberia extracts and uses thereof
Provided are compositions comprising an extract of Lilium siberia and a carrier. Also provided are methods of lightening the skin comprising the step of...
Medicine containing extracts of Ficus microcarpa for healing wounds of a
A medicine containing extracts of Ficus microcarpa for healing wounds including ulcerous wounds of a diabetic patient is provided. In one embodiment, the...
Orally administrable compositions comprising avocado/soybean
unsaponifiables and lipoic acid and methods of...
Methods comprising administration of: (i) avocado/soybean unsaponifiables and (ii) lipoic acid or derivatives thereof, to a mammalian or an avian subject are...
Fungal mycobiome as probiotics, diagnostics and therapeutics
The present invention relates to methods of using fungal mycobiome as a means of treating and/or diagnosing diseases in a subject. In one embodiment, the...
Method of preparation of compositions comprising dehydrated
The invention relates to a composition comprising revivable dehydrated micro-organisms. The invention is characterized in that it further comprises particles at...
Pharmaceutical composition including dead cells of Lactobacillus
acidophilus LB to treat or prevent allergic...
Provided is a pharmaceutical composition including dead cells of Lactobacillus acidophilus LB strain as an active ingredient for treating or preventing an...
Composition for inducing proliferation or accumulation of regulatory T
It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present...
Disclosed herein are compositions and methods useful for preparing neural scaffolds. The scaffolds comprise tissue taken from the spinal cord and/or dura mater...
Use of anti third party central memory T cells for anti-leukemia/lymphoma
A method of treating a disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting a non-syngeneic cell or tissue graft to the...
Biomaterials containing calcium phosphate
The invention relates to a biomaterial containing calcium phosphate, in particular hydroxyapatite or a material containing hydroxyapatite, such as biphasic...
Exercise physiology electrolyte management
The present invention provides methods for maintaining electrolyte balance and hydration in a person habituated to strenuous physical exertion by assaying...
Method and system for producing a substance or a signal with a coagulating
or anticoagulant effect
The invention concerns a method and a system for producing a signal, in particular an electric signal, or a substance having a coagulating or anticoagulant...
Method of inducing autophagy and activating toll-like receptor
A method of inducing autophagy in a cell is achieved by contacting the cell with graphene oxide (GO) in an amount effective to induce autophagy in the cell,...
Nitric oxide generating medical devices
Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices...
Treatment of compartment syndrome
The present invention relates to a method of treating or preventing compartment syndrome in a patient. According to the invention, the method includes: (a)...
Compositions and methods for inhibiting adhesion formation
Compositions and methods are provided for preparing an adhesion barrier that effectively reduce, prevent or treat adhesions in a patient in need thereof. In one...
Anti-cancer composition comprising alginate
Biologically acceptable composition for the prophylaxis and/or treatment of colorectal cancer. The composition contains an iron chelator, and the composition is...
Methods and compositions for preventing allergy and infection
To provide an IgA production promoter capable of being easily ingested safely and continually, for example orally and capable of preventing infection by...
Compositions and methods for treatment of melanoma
Described herein are compositions and methods for the prognosis, prevention and treatment of melanoma or melanoma associated symptoms. The compositions are...
Sweet taste receptor antagonist compositions
The present disclosure relates to compositions comprising gymnemic acid, together with a form of zinc to block the unpleasant bitter taste of gymnemic acid as...
Compositions and methods for borocarbohydrate complexes
Borocarbohydrate complex containing compositions are presented that have an improved di-complex to boric acid ratio. In some embodiments, compositions are...
Compositions and methods for reducing body fat
The present invention relates to compositions, such as bimatoprost, latanoprost and travoprost, and methods to reduce fat in the body of an individual, for...
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## ...
There is provided pyrimidinyl compounds of Formula (I), ##STR00001## wherein: R.sup.2 is ##STR00002## or pharmaceutically acceptable salts thereof,...
Selective HDAC1 and HDAC2 inhibitors
Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or...
N,N'-diarylurea compounds and N,N'-diarylthiourea compounds as inhibitors
of translation initiation
Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders,...
Styrenyl derivative compounds for treating ophthalmic diseases and
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and...
The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment,...
Methods for the treatment of solid tumors
Described herein are combinations of ACK inhibitors and HDAC inhibitors in the treatment of diseases and disorders characterized by the presence or development...
Pharmaceutical compositions comprising pemetrexed and tromethamine
A pharmaceutical composition of Pemetrexed represented by formula (I), ##STR00001## which is a liquid ready to use solution formulation or a lyophilized...
Hematological treatments based on levomefolate
Methods of treating hematological disorders including macrocytosis, and for decreasing hematological markers such as mean corpuscular volume, homocysteine and...