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Patent # Description
US-9,422,564 Immunostimulatory sequence oligonucleotides and methods of using the same
The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.
US-9,422,563 CD7 receptor aptamers
Nucleic acid aptamers which bind specifically to or are internalised into cells expressing a CD7 cell-surface receptor are disclosed. The aptamers comprise a...
US-9,422,562 Compositions and methods for inhibiting expression of CD274/PD-L1 gene
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to...
US-9,422,561 Treatment of disease by modulation of SIRT6
An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the...
US-9,422,560 Methods and compositions for neuroprotection
Disclosed herein are methods and kits useful for providing neuroprotection to neurons in the inner ear and to methods of treating inner ear diseases and...
US-9,422,559 Production and utilization of a novel anti-cancer drug in therapy
This invention generally relates to a design and method for developing novel anti-tumor and/or anti-cancer drugs, vaccines and therapies, using microRNA and/or...
US-9,422,558 Methods and compositions for weed control
The present invention provides novel compositions for use to enhance weed control. Specifically, the present invention provides for methods and compositions...
US-9,422,557 Methods and compositions for weed control
The present invention provides novel compositions for use to enhance weed control. Specifically, the present invention provides for methods and compositions...
US-9,422,556 RNAi-related inhibition of TNF-alpha signaling pathway for treatment of ocular angiogenesis
RNA interference is provided for inhibition of tumor necrosis factor .alpha. (TNF.alpha.) by silencing TNF.alpha. cell surface receptor TNF receptor-1 (TNFR1)...
US-9,422,555 Antisense oligonucleotides for inducing exon skipping and methods of use thereof
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
US-9,422,554 MicroRNAome
MicroRNAs (miRNAs) are a class of small noncoding RNAs that have important regulatory roles in multicellular organisms. The public miRNA database contains 321...
US-9,422,553 Prokaryotic RNAi-like system and methods of use
Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5' region and a 3' region. The 5' region includes, but...
US-9,422,552 Modified siNA
The present invention pertains to the use of at least one abasic modification within the first 8 nucleotide positions of the 5' region of the antisense strand...
US-9,422,551 Adapters for ligation to RNA in an RNA library with reduced bias
An improved adapter design for ligation to target RNA in a library is described which enables target RNAs that would normally be under-represented or not...
US-9,422,550 Protein and peptide libraries
Provided herein are, inter alia, methods for linking an mRNA molecule to a polypeptide (e.g., a peptide or a protein) by linking the mRNA molecule to a linking...
US-9,422,549 Methods for the production of libraries for directed evolution
Disclosed herein is an efficient method of generating a library of variants of a sequence of interest, such as may be used in directed evolution, in one...
US-9,422,548 OB-fold used as scaffold for engineering new specific binders
The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target...
US-9,422,547 Recombinant fusion proteins and libraries from immune cell repertoires
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
US-9,422,546 Methods for identifying and isolating cells expressing a polypeptide
The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate...
US-9,422,545 Lipopolysaccharide-targeted peptide mimic vaccine against Q fever
A vaccine and method of vaccination for conferring immunity to Q fever is described. The vaccine comprises a polypeptide with a sequence of SLTWHKHELHRK (SEQ ID...
US-9,422,544 Methods and kits for extraction of DNA
Methods and materials are disclosed for use in recovering a biopolymer from a solution. In particular, the invention provides methods for extraction and...
US-9,422,543 Isolation of nucleic acid
A method for isolating a nucleic acid comprises: binding the nucleic acid to a solid phase at a first pH in the presence of a binding buffer, washing the bound...
US-9,422,542 Process for parallel isolation and/or purification of RNA and DNA
The present invention relates to a process for the parallel isolation and/or purification of RNA and DNA from the same fixed biological sample, the...
US-9,422,541 Apparatus for the extracorporeal treatment of blood
An apparatus for the extracorporeal treatment of blood comprising an extracorporeal blood circuit (2), a pump (6) configured to provide fluid displacement...
US-9,422,539 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof,...
US-9,422,538 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof,...
US-9,422,537 Methods for using polypeptides having cellobiohydrolase activity
The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention...
US-9,422,536 Glucanases, nucleic acids encoding them and methods for making and using them
The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and...
US-9,422,535 phi29 DNA polymerase mutants having increased thermostability and processivity
Mutants of bacteriophage phi29 DNA polymerase with increased protein stability and increased half-life, compared to wild type DNA polymerase. The disclosed...
US-9,422,534 Synthesis of prazole compounds
The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the...
US-9,422,533 Nucleic acid encoding N-methylputrescine oxidase and uses thereof
The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently...
US-9,422,532 Nucleic acid encoding N-methylputrescine oxidase and uses thereof
The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently...
US-9,422,531 Biocatalysts for the preparation of hydroxy substituted carbamates
The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides,...
US-9,422,530 Ketoreductase polypeptides
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme...
US-9,422,529 Alphavirus compositions and methods of use
Embodiments are directed compositions related to Eilat virus and uses thereof. Certain aspects are directed to the detection of non-Eilat entities using a...
US-9,422,528 Influenza virus reassortment
New influenza donor strains for the production of reassortant influenza A viruses are provided.
US-9,422,527 Drug target site within gp120 of HIV
The present invention relates to a method of designing an inhibitor of the binding of HIV (human immunodeficiency virus) glycoprotein (gp)120 to a CD4-receptor...
US-9,422,526 Isolation, expansion and use of autologous pluripotent stem cells
The present invention relates to methods of isolating and culturing autologous pluripotent stem (aPS) cells. The present invention also provides isolated aPS...
US-9,422,525 Nuclear receptor and mutant thereof and the use of the same in the reprogramming of cells
According to the invention there is provided methods for inducing pluripotent stem cells in vitro, comprising introducing a gene or polypeptide of a nuclear...
US-9,422,524 Diabetes treatment
The invention is directed to a treatment of diabetes, a scaffold and a method of preparing a scaffold. In a first aspect, this object is met by providing a...
US-9,422,523 System and method for sorting cells
Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize...
US-9,422,522 Method of producing adipocytes from fibroblast cells
The present invention provides a method of producing progenitor cells, such as cells capable of being differentiated into a plurality of different cell types,...
US-9,422,521 Differentiation of pluripotent stem cells with a kinase inhibitor or PGI2
The present invention provides a process of differentiating stem cells, in particular hES cells, into cardiomyocytes and into neural progenitors by growing the...
US-9,422,520 System and method for generating a tool motion
System for generating the motion of a tool, in particular for the work on biological cell material, which includes an apparatus, the apparatus providing a tool...
US-9,422,519 Biomass hydrothermal decomposition system and saccharide-solution production method using biomass material
A biomass hydrothermal decomposition system includes a hydrothermal decomposition unit 17 that transports the fed biomass material from a lower side to an upper...
US-9,422,518 High solids enzyme reactor or mixer and method
A reactor apparatus including: an internal mixing chamber including a first chamber section having a cross-sectional area expanding from a biomass inlet to the...
US-9,422,517 Microscale and nanoscale structures for manipulating particles
The devices and systems described herein include one or more fluid paths, e.g., channels, and one or more selectively permeable obstacles arranged in the fluid...
US-9,422,516 Bioreactor chamber
A bioreactor chamber assembly comprising a cap and a base capable of being coupled together axially to define an internal chamber. The cap and base comprise...
US-9,422,515 Fermentation method and apparatus adapted for the method
A method for treating a vegetable product in the form of crushed material includes the steps of (i) storing the crushed material in a first vat to let it...
US-9,422,514 Point-of-production brewing system
A point-of-production brewing system which utilizes commercially available ocean and over-the-road shipping containers as a means to create a modular brewing...
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