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Porcine CD28 receptor, gene for encoding same, and application of same
Provided is a porcine CD28 receptor molecule, which is: 1) a protein consisting of an amino acid sequence represented by SEQ ID NO:2, or 2) a protein derived...
GPCR fusion protein containing an N-terminal autonomously folding stable
domain, and crystals of the same
Certain embodiments provide a GPCR fusion protein. In particular embodiments, the GPCR fusion protein comprises: a) a G-protein coupled receptor (GPCR); and b)...
Plexin D1 as a target for tumor diagnosis and therapy
The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1....
Glycosylated polypeptide and drug composition containing said polypeptide
[Problem] To provide a glycosylated polypeptide having an affinity to somatostatin receptors, and, compared to somatostatins, having improved in-blood...
Artificial signal peptide for expressing an insoluble protein as a soluble
The present invention relates to expression vectors and methods for enhancing soluble expression and secretion of an insoluble heterologous protein,...
Antibodies to IL-B50
Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this...
Process for purification of recombinant granulocyte colony stimulating
factor (rHu GCSF)
The present invention relates to methods for purification of recombinant human granulocyte colony stimulating factor (rHu GCSF). The present invention...
Fibroblast growth factor 21 variant, composition , and uses thereof
This present invention relates to pharmacologically potent and stable human fibroblast growth factor 21 (FGF21) variants, pharmaceutical compositions comprising...
The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7...
Isolated B7-H4 specific compositions and methods of use thereof
The present invention relates to B7-H4-specific chimeric antigen receptor compositions and methods of use thereof.
Target of EGR1 (TOE1) polypeptides for inhibition of HIV
Described are methods and compositions for preventing and/or treating HIV infection, as well as in vitro and in vivo methods of inhibiting HIV replication,...
N-terminal modified exendin-4
The present invention relates to an N-terminal amino acid-modified insulinotropic peptide having a high activity, and to a pharmaceutical composition comprising...
Production of a cysteine rich protein
The present invention relates to a method for the production of correctly folded Pfs48/45. This is achieved in the lactococcus lactis when Pfs48/45 or fractions...
Algal produced malarial transmission blocking vaccines
The present invention relates to the production of malaria transmission blocking vaccines in single-celled green algae, particularly algae of the genus...
Tobacco enzymes for regulating content of plant metabolites, and uses
The present invention provides a polynucleotide having a function of regulating a content of a plant metabolite, a polypeptide having a function of regulating a...
Polynucleotides are provided herein.
Transport protein which is used to introduce chemical compounds into nerve
The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein...
There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position...
Recoding method that removes inhibitory sequences and improves HIV gene
The invention relates to inhibitory nucleotide signal sequences or "INS" sequences in the genomes of lentiviruses. In particular the invention relates to the...
Method for producing cereulide and derivative thereof, intermediate for
production of cereulide, and cereulide...
The purpose of the present invention is to provide a novel method for producing cereulide and a derivative thereof; an intermediate for cereulide; and a novel...
Macrocyclic compounds useful as inhibitors of histone deacetylases
The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical...
Immunomodulating cyclic compounds
The present invention relates to novel cyclic compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The...
Compounds that bind to the erythropoietin receptor
The present invention provides mimetics of erythropoietin that bind to the erythropoietin receptor and that are suitable for use in pharmaceutical compositions....
Peptide compounds to regulate the complement system
The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated,...
Peptide for treatment of disease or symptoms associated with pain
The disclosure relates to a peptide (SEQ ID NO: 5), the use of said peptide for the treatment of the symptoms associated with pain, the use of said peptide for...
Modified toll-like receptor 2 (TLR2) ligands as inhibitors of neutrophil
The present invention provides modified TLR2 ligands useful for modulating inflammatory responses. In particular, the ligands comprise (a) a fatty acid di- or...
Plant-derived elastin binding protein ligands and methods of using the
The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and...
HCV protease inhibitors and uses thereof
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
Azaheterocycles as BIR2 and/or BIR3 inhibitors
Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, m, n and q are described in this...
2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the
treatment of cancer
Disclosed are compounds of Formula I or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R1, R2, R3, R4 and R5 are described herein, and methods of...
Preparative RP-HPLC method for purifying peptides
A method for separating on a RP-HPLC system a polypeptide of interest from at least one unwanted component is described, wherein at least one of the elution...
Optimized method for antibody capturing by mixed mode chromatography
Herein is reported a method for the purification of an antibody directly captured from clarified cell culture supernatants using Streamline CST and/or Capto...
Acoustic bioreactor processes
A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell...
Process for preparing crystalline ciclesonide with defined particle size
The invention relates to a novel process for preparing crystalline ciclesonide with an advantageous particle size and to the use for producing pharmaceutical...
Process for preparing 11-methylene-18-methyl-estr-4-en-3, 17-dione, useful
as intermediate compound for the...
There is described a process for the industrial synthesis of 11-methylene-18-methyl-estr-4-en-3,17-dione, a compound having the structure formula (I) depicted...
Glycosylation reactions using phenyl(trifluoroethyl)iodonium salts
Provided are methods for the preparation of glycosylation products, including those represented by formula I: Sugar-O--R' I comprising the step of combining...
6-substituted demethyl-estradiol derivatives as selective ER-.beta.
Disclosed herein are 6-substituted 13-demethyl-estradiol derivatives as selective ER.beta. agonists. Also disclosed is a method for treating pain by...
Uracyl spirooxetane nucleosides
The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R.sup.9 has the meaning as defined herein, or...
Substituted nucleosides, nucleotides and analogs thereof
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs...
Pyrimidine nucleoside derivatives, synthesis methods and uses thereof for
preparing anti-tumor and anti-virus...
The present invention relates to the field of pharmacochemistry. Disclosed are fluorinated and azido-substituted pyrimidine nucleoside derivatives, particularly...
C-terminal HSP90 inhibitors
Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment...
Bisaryl metallocenes and use thereof to produce polyolefins
The present disclosure provides metallocene catalysts for use in polymerization processes. Such catalysts may be used to generate polymers with low branching...
Epoxyeicosatrienoic acid analogs and methods of making and using the same
Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of...
Siloxane compound and process for producing the same
A siloxane compound comprises a plurality of siloxane repeating units and at least a portion of the siloxane repeating units are cyclosiloxane repeating units...
Method of preparing halogenated silahydrocarbylenes
A method comprises separate and consecutive steps (i) and (ii). Step (i) includes contacting a copper catalyst with hydrogen gas and a halogenated silane...
Organosiloxane composition having high refractive index and applications
containing the same
The invention is directed to a silicone compound of the general formula (I) and a personal care composition comprising the silicone compound (I) as described...
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid
pinacol esters and methods of using the same
Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a...
The present invention relates to compounds of general formula I, ##STR00001## wherein the group R.sup.1, R.sup.2, X, Y and Z are defined as in claim 1, which...
Compounds for the treatment of hepatitis C
The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The...