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Patent # Description
US-9,422,310 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds...
US-9,422,309 3-O-heteroaryl-ingenol
The present invention relates to a compound according to formula (I) wherein R.sub.1 represents optionally substituted heteroaryl, and pharmaceutically...
US-9,422,308 Derivatives of docosahexaenoylethanolamide and uses thereof
The invention provides derivatives of DEA which have increased potency and hydrolysis resistance as compared to DEA, and compositions thereof, as well as...
US-9,422,307 2,4,7-substituted thieno[3,2-d]pyrimidine compounds as protein kinase inhibitors
A substituted thieno pyrimidine compound of Formula 1, pharmaceutically acceptable salts and a pharmaceutical composition thereof is provided. ##STR00001## The...
US-9,422,306 Artemisinin compounds and synthesis and use thereof
The present disclosure describes artemisinin compounds. The compounds can be synthesized using an Ugi synthesis reaction and can be used in the treatment of...
US-9,422,305 Method for preparing curable bicyclic compound derived from biomass
The present invention relates to a curable bicyclic compound derived from biomass, solvent-free curable composition and a method for preparing thereof. The...
US-9,422,304 Synthesis of isohexide dicarbamates and derivatives thereof
Isohexide dicarbamates and a method of preparing the same are described. The method involves reacting a mixture of an isohexide and a cynate salt in a...
US-9,422,303 Formulations of water-insoluble chemical compounds and methods of using a formulation of compound FL118 for...
Provided are compositions, methods of making the compositions, and methods of using the compositions. The compositions can be provided as pharmaceutical...
US-9,422,302 Mixed .mu. agonist/ .delta. antagonist opioid analgesics with reduced tolerance liabilities and uses thereof
An opioid narcotics used for the treatment of moderate-to-severe pain that primarily exert their analgesic effects through .mu. receptors. Although, traditional...
US-9,422,301 Carboxamide bioisosteres of opiates
A compound of formula I is disclosed. ##STR00001## Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents,...
US-9,422,300 Bisulfate of janus kinase (JAK) inhibitor and preparation method therefor
The present invention relates to a bisulfate of a Janus kinase (JAK) inhibitor and a preparation method therefor. More specifically, the present invention...
US-9,422,299 Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
Novel compounds of Formula I ##STR00001## and their use in therapeutic treatments.
US-9,422,298 Pyridopyrimidine derivatives and use thereof
The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer...
US-9,422,297 Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s),...
US-9,422,296 Fast-dissociating dopamine 2 receptor antagonists
The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for...
US-9,422,295 Deuterated ibrutinib
The present invention in one embodiment provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein the variables shown in...
US-9,422,294 Cyclic compound, method for producing cyclic compound, and method for modifying biological molecule
The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The...
US-9,422,293 Tetrahydro-pyrimidoazepines as modulators of TRPV1
Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and...
US-9,422,292 Bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable...
US-9,422,291 Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
Antiviral compositions and methods are contemplated that are especially effective in the treatment and prevention of influenza A viruses. Also presented are...
US-9,422,290 Triazolopyridazine
Disclosed are compounds of general formula (I) ##STR00001## wherein the groups R.sup.1 to R.sup.3 have the meanings given in the claims and in the...
US-9,422,289 Use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and...
The present invention relates to the use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders...
US-9,422,287 Bridged triarylamines and -phosphines as materials for electronic devices
The present invention relates to a compound according to formula (I), to the use thereof in an electronic device and to an electronic device which comprises one...
US-9,422,286 Metal-binding bifunctional compounds as diagnostic agents for Alzheimer's disease
Metal-binding bifunctional compounds and their use as diagnostic agents for Alzheimer's disease and other beta amyloid disorders are disclosed. Also,...
US-9,422,285 Substituted pyrazolo[1,5-A]-pyridine-3-carboxamides and use thereof
The present application relates to novel pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in...
US-9,422,284 Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
Compounds of the formula (I) useful as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors ##STR00001##
US-9,422,283 Salts and polymorphs of a substituted imidazopyridinyl-aminopyridine compound
The present application relates to salts of Compound A, 3-(3-(4-(1-aminocyclobutyl) phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine, solid ...
US-9,422,282 Compounds and method for treatment of HIV
The invention relates to a compound of Formulae I and/or II: ##STR00001## and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical...
US-9,422,281 Benzopiperazine compositions as BET bromodomain inhibitors
The present invention relates to inhibitors of bromo and extra terminal (BET) br`omodomains that are useful for the treatment of cancer, inflammatory diseases,...
US-9,422,280 N-substituted hetero-bicyclic compounds and derivatives for combating animal pests II
The invention relates to N-substituted hetero-bicyclic compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions...
US-9,422,279 Compounds and uses thereof for the modulation of hemoglobin
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
US-9,422,278 Pesticidal compositions and processes related thereto
This document discloses molecules having the following formula ("Formula One"): ##STR00001## and processes related thereto.
US-9,422,277 Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use
In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): and tautomers and...
US-9,422,276 Use of aryl and hetaryl carboxamides as endoparasiticides
The present application relates to known and novel aryl- and hetarylcarboxamides of the formula (I) ##STR00001## and to their use as medicaments for...
US-9,422,275 Small molecule modifiers of the HEC1-NEK2 interaction in G2/M
Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: ##STR00001## In Formula 1, Z is...
US-9,422,274 Oxazolidinone derivatives and composition for preventing or treating hepatitis C containing the same
The present invention relates to oxazolidinone compounds represented by Chemical Formula 1, pharmaceutically acceptable salts thereof or hydrates, a method of...
US-9,422,273 Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
The present invention provides compounds, that are N-alkyl-2-(1-(5-substituted-2-(3-oxo-3-(trifluoromethylsulfonamido)propyl- ...
US-9,422,272 Compounds
Compounds of formula (I): ##STR00001## are described herein. Compounds of the disclosure are modulators of Kv3 channels and may be used in the prophylaxis or...
US-9,422,271 Pyrimidine compounds as tuberculosis inhibitors
The present invention relates to compounds useful as inhibitors of treating tuberculosis. The invention also provides processes for preparing compounds of the...
US-9,422,270 Melam granulate material and process for preparation thereof
The invention relates to a method for producing a free flowing flame retardant material, comprising steps of i. preparing an aqueous slurry from a freshly...
US-9,422,268 Substituted benzylpyrazoles
Compounds of formula (I) and their use as pharmaceutical. ##STR00001##
US-9,422,267 Fused pyrimidine compounds and use thereof
The present invention provides fused pyrimidine compounds of the general Formula (I): ##STR00001## or a salt thereof, wherein the variables are as defined in...
US-9,422,266 Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
Substituted cyclopropyl compounds of the formula I and the pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2...
US-9,422,265 Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
This disclosure relates to the field of preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine and intermediates therefrom. These intermediates are useful in the...
US-9,422,264 Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment...
US-9,422,263 Fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and...
The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives having protein tyrosine...
US-9,422,262 Compounds and methods for treating diseases mediated by protease activated receptors
The invention relates to the use of a compound of Formula I for the treatment of protease-activated receptor mediated diseases by the administration of a...
US-9,422,261 Heterocyclic resorcinol derivatives, preparation of same and cosmetic uses thereof
The invention relates to a compound of general formula (I) ##STR00001## characterized in that: R.sub.1 is a C.sub.1-C.sub.4 alkyl group, and R.sub.2 is an...
US-9,422,260 Process for the synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isoben- ...
A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction,...
US-9,422,259 Synthetic transtaganolide and basiliolide products, derivatives thereof, and synthesis methods thereof
Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of...
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