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Gonadotropin-releasing hormone receptor antagonists and methods relating
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds...
The present invention relates to a compound according to formula (I) wherein R.sub.1 represents optionally substituted heteroaryl, and pharmaceutically...
Derivatives of docosahexaenoylethanolamide and uses thereof
The invention provides derivatives of DEA which have increased potency and hydrolysis resistance as compared to DEA, and compositions thereof, as well as...
2,4,7-substituted thieno[3,2-d]pyrimidine compounds as protein kinase
A substituted thieno pyrimidine compound of Formula 1, pharmaceutically acceptable salts and a pharmaceutical composition thereof is provided. ##STR00001## The...
Artemisinin compounds and synthesis and use thereof
The present disclosure describes artemisinin compounds. The compounds can be synthesized using an Ugi synthesis reaction and can be used in the treatment of...
Method for preparing curable bicyclic compound derived from biomass
The present invention relates to a curable bicyclic compound derived from biomass, solvent-free curable composition and a method for preparing thereof. The...
Synthesis of isohexide dicarbamates and derivatives thereof
Isohexide dicarbamates and a method of preparing the same are described. The method involves reacting a mixture of an isohexide and a cynate salt in a...
Formulations of water-insoluble chemical compounds and methods of using a
formulation of compound FL118 for...
Provided are compositions, methods of making the compositions, and methods of using the compositions. The compositions can be provided as pharmaceutical...
Mixed .mu. agonist/ .delta. antagonist opioid analgesics with reduced
tolerance liabilities and uses thereof
An opioid narcotics used for the treatment of moderate-to-severe pain that primarily exert their analgesic effects through .mu. receptors. Although, traditional...
Carboxamide bioisosteres of opiates
A compound of formula I is disclosed. ##STR00001## Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents,...
Bisulfate of janus kinase (JAK) inhibitor and preparation method therefor
The present invention relates to a bisulfate of a Janus kinase (JAK) inhibitor and a preparation method therefor. More specifically, the present invention...
Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor
Novel compounds of Formula I ##STR00001## and their use in therapeutic treatments.
Pyridopyrimidine derivatives and use thereof
The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer...
Tricyclic compounds having cytostatic and/or cytotoxic activity and
methods of use thereof
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s),...
Fast-dissociating dopamine 2 receptor antagonists
The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for...
The present invention in one embodiment provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein the variables shown in...
Cyclic compound, method for producing cyclic compound, and method for
modifying biological molecule
The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The...
Tetrahydro-pyrimidoazepines as modulators of TRPV1
Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and...
Bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable...
Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
Antiviral compositions and methods are contemplated that are especially effective in the treatment and prevention of influenza A viruses. Also presented are...
Disclosed are compounds of general formula (I) ##STR00001## wherein the groups R.sup.1 to R.sup.3 have the meanings given in the claims and in the...
Use of pteridine derivatives for the treatment of increased intracranial
pressure, secondary ischemia, and...
The present invention relates to the use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders...
Bridged triarylamines and -phosphines as materials for electronic devices
The present invention relates to a compound according to formula (I), to the use thereof in an electronic device and to an electronic device which comprises one...
Metal-binding bifunctional compounds as diagnostic agents for Alzheimer's
Metal-binding bifunctional compounds and their use as diagnostic agents for Alzheimer's disease and other beta amyloid disorders are disclosed. Also,...
Substituted pyrazolo[1,5-A]-pyridine-3-carboxamides and use thereof
The present application relates to novel pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in...
Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase
Compounds of the formula (I) useful as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors ##STR00001##
Salts and polymorphs of a substituted imidazopyridinyl-aminopyridine
The present application relates to salts of Compound A, 3-(3-(4-(1-aminocyclobutyl) phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine, solid ...
Compounds and method for treatment of HIV
The invention relates to a compound of Formulae I and/or II: ##STR00001## and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical...
Benzopiperazine compositions as BET bromodomain inhibitors
The present invention relates to inhibitors of bromo and extra terminal (BET) br`omodomains that are useful for the treatment of cancer, inflammatory diseases,...
N-substituted hetero-bicyclic compounds and derivatives for combating
animal pests II
The invention relates to N-substituted hetero-bicyclic compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions...
Compounds and uses thereof for the modulation of hemoglobin
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
Pesticidal compositions and processes related thereto
This document discloses molecules having the following formula ("Formula One"): ##STR00001## and processes related thereto.
Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors,
compositions and their use
In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): and tautomers and...
Use of aryl and hetaryl carboxamides as endoparasiticides
The present application relates to known and novel aryl- and hetarylcarboxamides of the formula (I) ##STR00001## and to their use as medicaments for...
Small molecule modifiers of the HEC1-NEK2 interaction in G2/M
Certain embodiments of the present invention provide selected compounds having a molecular structure according to Formula 1: ##STR00001## In Formula 1, Z is...
Oxazolidinone derivatives and composition for preventing or treating
hepatitis C containing the same
The present invention relates to oxazolidinone compounds represented by Chemical Formula 1, pharmaceutically acceptable salts thereof or hydrates, a method of...
Compounds act at multiple prostaglandin receptors giving a general
The present invention provides compounds, that are N-alkyl-2-(1-(5-substituted-2-(3-oxo-3-(trifluoromethylsulfonamido)propyl- ...
Compounds of formula (I): ##STR00001## are described herein. Compounds of the disclosure are modulators of Kv3 channels and may be used in the prophylaxis or...
Pyrimidine compounds as tuberculosis inhibitors
The present invention relates to compounds useful as inhibitors of treating tuberculosis. The invention also provides processes for preparing compounds of the...
Melam granulate material and process for preparation thereof
The invention relates to a method for producing a free flowing flame retardant material, comprising steps of i. preparing an aqueous slurry from a freshly...
Compounds of formula (I) and their use as pharmaceutical. ##STR00001##
Fused pyrimidine compounds and use thereof
The present invention provides fused pyrimidine compounds of the general Formula (I): ##STR00001## or a salt thereof, wherein the variables are as defined in...
Substituted cyclopropyl compounds, compositions containing such compounds
and methods of treatment
Substituted cyclopropyl compounds of the formula I and the pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2...
Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
This disclosure relates to the field of preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine and intermediates therefrom. These intermediates are useful in the...
Carbamate-substituted oxindole derivatives and use thereof for the
treatment of vasopressin-dependent diseases
The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment...
The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives having protein tyrosine...
Compounds and methods for treating diseases mediated by protease activated
The invention relates to the use of a compound of Formula I for the treatment of protease-activated receptor mediated diseases by the administration of a...
Heterocyclic resorcinol derivatives, preparation of same and cosmetic uses
The invention relates to a compound of general formula (I) ##STR00001## characterized in that: R.sub.1 is a C.sub.1-C.sub.4 alkyl group, and R.sub.2 is an...
Process for the synthesis of
A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction,...
Synthetic transtaganolide and basiliolide products, derivatives thereof,
and synthesis methods thereof
Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of...