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Reduction of HMF ethers with metal catalyst
Methods of making reduced derivatives of hydroxymethyl furfural using metal catalysts are described. The derivatives may have tetrahydrofuran or furan nucleus...
Process for making HMF from sugars with reduced byproduct formation, and
improved stability HMF compositions
Disclosed is a process for making HMF' or a derivative of HMF by dehydrating one or more hexose sugars in a reduced oxygen environment, in another, related...
Continuous process for producing epichlorohydrin from glycerol
A process for the continuous production, through the glycerine route, of epichlorohydrin from dichlorohydrins, in the presence of an alkali solution, wherein...
S-imino-S-oxo-iminothiazine compounds as BACE inhibitors, compositions,
and their use
In its many embodiments, the present invention provides certain S-imino-S-oxo iminothiazine compounds, including compounds Formula (I): or a tautomers and/or...
Methoxyacrylate-based fungicide and methods for preparing and using the
A pharmaceutical composition of fungicide including at least a compound represented by Formula (I). ##STR00001## The pharmaceutical composition of fungicide...
Cyclic triazo and diazo sodium channel blockers
A method of treating a disorder such as epilepsy, multiple sclerosis, glaucoma and uveitis, cerebral traumas and cerebral ischaemias, stroke, head injury,...
Triazoles as Kv3 inhibitors
Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders. ...
Metal complexes of poly(carboxyl)amine-containing ligands having an
affinity for carbonic anhydrase IX
A ligand, a pharmaceutically acceptable salt, tautomer, or ester thereof, may be represented as: ##STR00001## In the formula, X is selected from the group...
Pyrimidine derivatives for the treatment of viral infections
This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such...
Preparation of pyrimidine intermediates useful for the manufacture of
The present invention relates to a new synthetic intermediate, namely the compound of formula I-2 ##STR00001## or a salt thereof. Said compound of formula I-2...
Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having
A substituted phenol compound represented by Formula I: ##STR00001## or a pharmaceutically acceptable salt or prodrug thereof. At least one of X and Y is CH,...
Fe(III) complex compounds for the treatment and prophylaxis of iron
deficiency symptoms and iron deficiency anemias
The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment...
Benzylidene azolidine derivative or salt thereof
A novel compound which has excellent ultraviolet-absorbing function (especially UVA absorbing function) and excellent hydrophilicity. A benzylidene azolidine...
In one aspect, the invention relates to compounds having the formula: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as defined in the...
Synthesis of substituted pyrazoline carboxamidine derivatives
This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as...
3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors
There are provided substituted 3-phenyl-isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly(ADP-ribose) polymerase PARP-1 with...
Phosphodiesterase inhibitors and uses thereof
The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and...
Demethylpenclomedine analogs and their use as anti-cancer agents
This disclosure concerns novel demethylpenclomedine analogs. Also disclosed are pharmaceutical compositions and methods for using such compositions to treat...
Partially saturated nitrogen-containing heterocyclic compound
There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): ##STR00001## (in the above-mentioned...
Dual PPAR-.delta. PPAR-.gamma. agonists
The present disclosure provides novel compounds with activity as PPAR.beta./.delta. and PPAR.gamma. dual agonists. The disclosure also provides methods of...
The invention provides a 1,3,5-substituted indole wherein the substituent at position 1 is a C6 to C12 alkyl group; the substituent at position 3 is...
Covalently patterned graphene surfaces by a force accelerated
The present invention relates generally to molecular printing techniques for use in sensors, arrays, and integrated optics and electronics. The invention...
Phenicol antibacterial agents
The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical compositions containing these...
Sulfonamide derivatives with therapeutic indications
The invention provides sulfonamide compounds of formula (I) as defined herein, pharmaceutical compositions containing the same and methods of treatment using...
Prostate specific membrane antigen (PSMA) targeted nanoparticles for
therapy of prostate cancer
The invention provides a nanoparticle composition that is decorated with a urea-based small-molecule peptidomimetic inhibitor of prostate specific membrane...
Vanilloid fatty hydroxamates as therapeutic anti-inflammatory
Three unique subtypes of N-hydroxyamides and N-hydroxycarbamates containing both the vanilloid moiety (4-hydroxy-3-methoxybenzyl) and a lipophilic aliphatic...
Reductive release probes containing a chemoselectively cleavable
.alpha.-azidoether linker and methods of use...
Probes comprising one or more selectively cleavable .alpha.-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable...
Method for inhibiting Trypanosoma cruzi
Methods are provided to inhibit proliferation of Trypanosoma cruzi with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an...
Process for the preparation of an anticonvulsant agent pregabalin
An efficient synthesis of the anticonvulsant drug, Pregabalin hydrochloride is described using simple transformations in high enantiopurity (>99% ee) and...
The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to...
Process for the preparation of optically pure fesoterodine derivatives
3,3-diphenylpropylamines of general formula (I), particularly Fesoterodine, as well as their enantiomers, solvates and salts, can be produced by treating a...
Substituted naphthalenes as feedstock for plasticizer production
Provided are compounds and processes of making compounds of the formula: ##STR00001## wherein x=4 to 8, R is H, C.sub.1 to C.sub.4 alkyl, --C(O)OR.sub.1 or...
Process for preparing high purity and crystalline dimethyl fumarate
The present invention describes a process for the preparation of dimethyl fumarate. The process involves the esterification of fumaric acid and methanol in the...
Substituted phenethylamines with serotoninergic and/or norepinephrinergic
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof,...
Methods of treatment using a BCAT1 inhibitor
The present invention is directed to BCAT inhibitors with the following formula: ##STR00001## Wherein R.sub.1 is a linear alkyl group and X.sup.+ denotes a...
Compounds and methods for delivery of prostacyclin analogs
This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus...
Process for production of acrylic acid or its derivatives from
hydroxypropionic acid or its derivatives
Processes for the catalytic dehydration of hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid...
Method for the restabilization of (meth)acrylic monomers
A process for replacing the stabilization of (meth)acrylic monomers, wherein phenothiazine is removed from phenothiazine-containing (meth)acrylic monomers by...
Method for purifying carboxylic acids from fermentation broths
Method and devices for separating and purifying carboxylic acids from fermentation broths comprising carboxylic acid ammonium salts are disclosed herein. The...
Pressurized crude aromatic carboxylic acid feed mixes
Processes for manufacturing a purified aromatic carboxylic acid include heating a purification reaction mixture in a pre-heating zone, the purification reaction...
Process for recharging the reaction tubes of a tube bundle reactor with a
new fixed catalyst bed
A process for recharging the reaction tubes of a tube bundle reactor with a new fixed catalyst bed, in which a heterogeneously catalyzed partial gas phase...
Carboxylic acid recovery from magnesium carboxylate mixture
The invention is directed to a method for recovering carboyxlic acid from an magnesium carboxylate containing aqueous mixture, including the steps of:...
Method for synthesis of lactic acid and its derivatives and catalyst for
The present disclosure provides a catalyst for preparing lactic acid and derivatives thereof, comprising at least one of metallic compounds MX.sub.n, wherein M...
Catalytic reductive cleavage of a .beta.-O-4 bond of ethers or polyethers
such as lignin
The present invention relates to a method of cleaving a .beta.-O-4 bond to the corresponding C--H bond in a substrate, by use of a hydrogen donor and a metal...
Method for scale extraction Quebrachitol from natural rubber industry
Provided is a method for scale extraction of quebrachitol from natural rubber industry waste water, the method comprising the following steps: coarsely...
Method for producing dimethyl ether and device suitable therefor
The present disclosure relates to a method and apparatus for producing dimethyl ether by catalytic dehydration of methanol and by distillation of the...
Recovery of CO.sub.2 in a process for the synthesis of methanol
A process for producing methanol, where a hydrocarbon feedstock (1) is reformed and a make-up syngas is reacted in a synthesis loop, obtaining crude methanol...
Process for producing 2,3,3,3-tetrafluoropropene
The present invention provides a process for producing 2,3,3,3-tetrafluoropropene, comprising the steps of producing 2-chloro-3,3,3-trifluoropropene by reacting...
Recovery of ethylene from methanol to olefins process
Olefins may be recovered from a methanol to olefins reactor effluent by initially feeding the effluent to an absorber demethanizer to contact the effluent with...
Propylene via metathesis with low or no ethylene
A process for producing propylene is disclosed, including: fractionating a mixed C4 hydrocarbon stream to recover a first fraction comprising isobutene and a...