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Patent # Description
US-9,428,555 Truncated L1 protein of Human Papillomavirus type 16
The invention relates to a truncated L1 protein of the Human Papillomavirus Type 16, a virus-like particle consisting of the protein, a vaccine comprising said...
US-9,428,554 Monoclonal antibody against hepatitis E virus or its fragment with binding activity and use thereof
The present invention relates to monoclonal antibody specifically binding to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of...
US-9,428,553 Meditopes and meditope-binding antibodies and uses thereof
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies,...
US-9,428,552 Stem cell mobilization and tissue repair and regeneration
Stem cells are mobilized from bone marrow by administering an amount of Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gln-Val-Ser-Asp-Lys-Pro (SEQ ID NO: 2) or ...
US-9,428,551 Antimicrobial peptides
The present invention provides novel therapeutic antimicrobial peptides that are bactericides and have an inhibitory effect on biofilms produced by...
US-9,428,550 Peptides and methods and uses thereof for preventing retinal disorders
The present disclosure relates to methods and uses of C-terminal peptides for inhibiting neuronal cell death or dysfunction, such as retinal ganglion cell death...
US-9,428,549 Derivatives of N-urea substituted amino acids as formyl peptide receptor modulators
The present invention relates to derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and...
US-9,428,548 Enhanced protein purification through a modified protein A elution
The present invention provides methods for purifying a polypeptide comprising a CH2/CH3 region, comprising binding the polypeptide to Protein A and eluting with...
US-9,428,547 Compositions for isolating a target analyte from a heterogeneous sample
The invention generally relates to compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a...
US-9,428,546 Tandem purification of proteins
The present disclosure provides methods for purifying products from a fluid. In some embodiments, provided purification methods use a combination of...
US-9,428,545 Process for isolation of plasma or serum proteins
The present invention provides a process for the isolation of one or more proteins from a protein solution. This process comprising the steps of: a) providing a...
US-9,428,544 Method for purifying protein
It is an object of the present invention to provide a method for eluting an adsorbed protein that suppresses a decrease in protein adsorption ability, in a...
US-9,428,543 Preparation of maytansinoid antibody conjugates by a one-step process
The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a...
US-9,428,542 Lupane triterpenoid derivatives and pharmaceutical use thereof
The present invention relates to a lupane triterpenoid derivatives and pharmaceutical use thereof, specifically relates to a lupane triterpenoid derivatives of...
US-9,428,541 Substrate reduction therapy
The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary...
US-9,428,540 Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents
The present invention relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides-fatty acid esters of glucocorticoids as...
US-9,428,539 2.beta.,3.alpha.,5.alpha.-trihydroxy-androst-6-one and preparation methods and use thereof
The present invention discloses compound 2.beta.,3.alpha.,5.alpha.-trihydroxy-androst-6-one, having the structure of formula (I). The present invention also...
US-9,428,538 Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
The present invention relates to an optimized in vivo delivery system with endosomolytic agents for nucleic acid of therapeutic interest conjugated to molecules...
US-9,428,537 tRNA derived small RNAs (tsRNAs) involved in cell viability
The present invention features compositions and methods relating to tRNA-derived small RNAs (tsRNAs). Provided herein are oligonucleotide compositions that are...
US-9,428,536 Immunostimulatory G, U-containing oligoribonucleotides
Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands...
US-9,428,535 Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one...
US-9,428,534 Antisense design
A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved...
US-9,428,533 Inhibitors of advanced glycation end products
The present invention provides compounds of the formula, ##STR00001## wherein A, B, G, R.sup.2, R.sup.6, and X are defined herein, pharmaceutical compositions...
US-9,428,532 Methods for making biocompatible polymerizable acrylate products
Sugar-acrylic monomers are synthesized to have a carbohydrate moiety linked to an acrylate group. The sugar-acrylic monomers may be polymerized to form...
US-9,428,531 Cyclic nickel-based complexes and their use in a process for the transformation of olefins
The invention describes a novel type of nickel-based complex and its preparation method. The invention also concerns the use of said complex in a process for...
US-9,428,530 Derivatives of oxazaphosphorines that are pre-activated, use and method of preparation
The present invention relates to novel derivatives of oxazaphosphorines that are pre-activated, to the methods for preparing same, to the pharmaceutical...
US-9,428,529 Process for purification of trivalent phosphorous ligands that can be used for preparation of catalysts
The present invention provides processes for purifying a trivalent phosphorous ligand that can be used for the preparation of catalysts for a hydroformylation...
US-9,428,528 Phenicol antibacterials
The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these...
US-9,428,527 Symmetric hyperbranched type silicone-modified polymerizable compound, and its modularized preparation method
A symmetric hyperbranched type silicone-modified polymerizable compound contains a compound represented by the following general formula (1). A hyperbranched...
US-9,428,525 Tunable electrical conductivity in metal-organic framework thin film devices
A composition including a porous metal organic framework (MOF) including an open metal site and a guest species capable of charge transfer that can coordinate...
US-9,428,524 Synthetic process for the manufacture of ecteinascidin compounds
This invention relates to compounds of formula II: wherein R.sub.1, R.sub.2, Prot.sup.SH, and Prot.sup.NH are as defined, to processes for the synthesis of...
US-9,428,523 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,- 3-thiazol-4-yl amides
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have...
US-9,428,522 Piperazines, pharmaceutical compositions and methods of use thereof
Disclosed are novel piperazine derivatives that act as agonists of the .alpha.7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating...
US-9,428,521 Process for the production of a carbodiimide
A process for the production of a carbodiimide, comprising the steps of: (1) reacting an amine represented by the following formula (A) with carbon disulfide...
US-9,428,520 Daphne genkwa extracts, and pharmaceutical composition containing fractions of the extracts or compounds...
The present invention relates to a pharmaceutical composition for the prevention or treatment of atopy comprising the extract of Daphne genkwa, the fraction...
US-9,428,519 Acylated derivative of homoharringtonine, preparation method therefor, and application thereof
The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and relates to novel homoharringtonine acylated derivatives of...
US-9,428,518 Perylenemonoimide and naphthalenemonoimide derivatives and their use in dye-sensitized solar cells
A sensitizer in a dye-sensitized solar cell, including a compound of formula (I') ##STR00001## where: R.sup.1 and R.sup.2 are hydrogen, a halogen, an alkyl...
US-9,428,517 Protease inhibitors
Compounds of the formula II: ##STR00001## wherein R.sup.1 and R.sup.2 are independently H, F or CH.sub.3; or R.sup.1 forms an ethynyl bond and R.sup.2 is H...
US-9,428,516 Crystalline forms of morphine sulfate
The present disclosure is directed to crystalline forms of morphine sulfate and pharmaceutical compositions comprising any of the crystalline forms of morphine...
US-9,428,515 Benzimidazole derivatives
The present invention encompasses compounds of the general formula I ##STR00001## wherein the groups A, R.sup.1 to R.sup.2 and X have the meanings given in the...
US-9,428,514 Bromodomain inhibitors
The present invention provides for compounds of formula (I) ##STR00001## wherein Y.sup.1, Y.sup.2, R.sup.1, R.sup.2, R.sup.3, A.sup.1, A.sup.2, A.sup.3, and...
US-9,428,513 Triazolopyrazine
The present invention encompasses compounds of general formula (I) ##STR00001## wherein the groups R.sup.1 to R.sup.3, X.sub.3 to X.sub.6 have the meanings...
US-9,428,512 Compounds
The present invention relates to compounds of formula (I) and salts thereof: ##STR00001## wherein R.sub.1 is n-C.sub.3-6alkyl; R.sub.2 is hydrogen or methyl;...
US-9,428,511 Imidazopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity...
US-9,428,510 Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing Trk
The present invention relates to a compound of following formula (I) or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a...
US-9,428,509 Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
Provided herein are Pyrrolopyrimidine Compounds having the following structure: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and L are as defined herein,...
US-9,428,508 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors
The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their...
US-9,428,507 Compounds for the treatment of malaria
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the...
US-9,428,506 Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
The invention relates to particular substituted heterocycle fused gamma-carbolines, of Formula I, in free, solid, pharmaceutically acceptable salt and/or...
US-9,428,505 Hydantoin derivative
The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof: ##STR00001## wherein R.sub.1,...
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