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Patent # Description
US-9,434,764 Skin care compositions and methods comprising selective agonists of melanocortin 1 receptor
Short tri- and tetrapeptides according to the following Formula I Ar(CH.sub.2).sub.mX.sup.1--X.sup.2--CO--X.sup.3--X.sup.4--X.sup.5-(Trp).s- ub.n-NX.sup.6R are...
US-9,434,763 Derivatives of pyridinone as inhibitors for tissue transglutaminase
The invention relates to pyridinone derivatives of general formula (I) as inhibitors of tissue transglutaminase, to methods for producing the pyridinone...
US-9,434,762 Macrocyclic cysteine protease inhibitors and compositions thereof
The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates...
US-9,434,761 Tripeptide epoxy ketone protease inhibitors
Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the...
US-9,434,760 Prolinamide derivatives as thrombin inhibitors, preparation method and application thereof
Provided are a compound of formula (I), pharmaceutically acceptable salts thereof, preparation methods and applications thereof for inhibiting thrombin, and...
US-9,434,759 Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
Cationic steroidal antimicrobial (CSA) compounds having amide functionality and methods of manufacturing such CSA compounds. The CSA compound can be a compound...
US-9,434,758 Non-hormonal steroid modulators of NF-.kappa.B for treatment of disease
The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors...
US-9,434,756 Crystalline 4'-epidaunorubicin hydrochloride and use thereof
4'-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes...
US-9,434,755 Process for the isolation of rhamnolipids
A process for isolating rhamnolipids is provided. The process includes providing an aqueous medium containing at least one rhamnolipid and having a pH of less...
US-9,434,754 Use of an adrenal hormone-modifying agent
The present invention relates to a method of treating a disease or disorder characterized by increased stress hormone levels and/or decreased androgen hormone...
US-9,434,753 Modified creatine compounds
The invention discloses creatine derivatives that are represented by Formula (I), Formula (II), and Formula (III); wherein Z is a functional group; Y is a...
US-9,434,752 Dinuclear metallocene compound, and a method for preparing the same
The present invention relates to a dinuclear metallocene compound with a new structure which can manufacture polyolefin having high molecular weight and to a...
US-9,434,751 Alkylalkoxysilane compounds containing ether group and dialkylamino group and process for preparing the compounds
The present invention relates to an alkylalkoxysilane compound of a novel structure which has an ether group and an dialkylamino group in an alkyl chain of the...
US-9,434,750 Branched siloxanes and methods for synthesis
The present invention describes branched and functionalized siloxanes and methods for making such compounds. The compounds have a variety of uses. One preferred...
US-9,434,749 Platinum catalyzed hydrosilylation reactions utilizing cyclodiene additives
A process for the hydrosilylation of an unsaturated compound comprising reacting (a) a silyl hydride with (b) an unsaturated compound in the presence of (c) a...
US-9,434,748 Cytotoxic benzodiazepine derivatives
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula...
US-9,434,747 Methods of treating diabetes
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic...
US-9,434,746 Pyrimidinones as PI3K inhibitors
The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases...
US-9,434,745 7-oxo-thiazolopyridine carbonic acid derivatives and their use in the treatment, amelioration or prevention of...
The present invention relates to a compound having the general formula (A), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph,...
US-9,434,744 Low temperature synthesis of rapamycin derivatives
The present invention provides improved processes for obtaining rapamycin derivatives including Biolimus A9.
US-9,434,743 Indazole derivatives
Disclosed are compounds of Formula 1, ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and...
US-9,434,742 Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory...
US-9,434,741 Thieno[2,3-d]pyrimidine derivatives, preparation method and use thereof
This disclosure provides thieno[2,3-d]pyrimidine compounds containing isoxazole heterocycle represented by formula (I), or pharmaceutically acceptable salts...
US-9,434,740 Taxane compounds, compositions and methods
The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
US-9,434,739 Systemic insecticide
Disclosed are compounds that are utilizable as systemic insecticides and possess excellent systemic properties. Compounds represented by formula (1) have...
US-9,434,738 Macrocyclic benzofuran and azabenzofuran compounds for the treatment of hepatitis C
Compounds of formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
US-9,434,737 Process for producing optically active succinimide derivatives and intermediates thereof
Provided is a process for producing (3R)-2'-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a- ]pyrazine}-1',2,3',5(2'H)-tetraone (compound A)....
US-9,434,736 Compounds, compositions and methods of agelastatin alkaloids
The present invention, among other things, provides compounds, compositions and methods for treatment of cancer. In some embodiments, the present invention...
US-9,434,735 Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]p- ...
Provided herein is an amorphous form of 4-((4-(Cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo[2,3-d]p- ...
US-9,434,734 Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic...
The present invention relates to the pyrazoloquinazolinone and pyrroloquinazolinone derivatives of the general formula (I), as well as pharmaceutical...
US-9,434,733 PDE9 inhibitors with imidazo triazinone backbone
This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically...
US-9,434,732 Triazolopyridine JAK inhibitor compounds and methods
A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and...
US-9,434,731 Imidazo-, pyrazolopyrazines and imidazotriazines and their use
The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of...
US-9,434,730 PDE1 inhibitor compounds
The present invention relates to (1- or 2- and/or 5 and/or 7-substituted)-(3-oxy)-(4H,4-imino, 4-thioxo or 4-oxo)-pyrazolo[3,4-d]pyrimidin-6-ones, e.g., a...
US-9,434,729 Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and...
US-9,434,728 Nitrogen containing compounds and their use
Compound of Formula (I), its preparation and use in preventing or treating bacterial infection is disclosed. Formula (I) ##STR00001##
US-9,434,727 Substituted 4-phenylpiperidines, their preparation and use
The present invention provides a compound having the structure: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are each independently...
US-9,434,726 Substituted pyrido[3,4-b]pyrazines as Syk inhibitors
Provided are pyridopyrazine compounds of formula (I), pharmaceutical compositions thereof and methods of use therefore, wherein R.sup.1, R.sup.2, R.sup.3,...
US-9,434,725 5-azaindazole compounds and methods of use
5-Azaindazole compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for...
US-9,434,724 Quinuclidines for modulating alpha 7 activity
Provided are substituted quinuclidine compounds, pharmaceutical compositions comprising such compounds, and methods of modulating .alpha.7 nicotinic...
US-9,434,723 Heteroarylpiperidine and -piperazine derivatives as fungicides
Heteroarylpiperidine and -piperazine derivatives of the formula (I) in which the symbols A, X, Y, L.sup.1, L.sup.2, G, Q, p, R.sup.1, R.sup.2 and R.sup.10 are...
US-9,434,722 Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases
This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative...
US-9,434,721 Therapeutic agents useful for treating pain
A compound of formula: ##STR00001## wherein Ar.sub.1, A, R.sub.3, x, and m are as disclosed herein and Ar.sub.2 is a benzothiazolyl, benzooxazolyl, or...
US-9,434,720 Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
Topical formulations and method of using the same are provided. The topical formulation comprises a pyrazolylbenzothiazole derivative of the following formula...
US-9,434,719 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
The invention is directed to a formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2a, R.sup.2b and...
US-9,434,718 TOFA analogs useful in treating dermatological disorders or conditions
This invention is directed to analogs of 5-(tetradecyloxy)-2-furancarboxylic acid (TOFA) and their use in the treatment of dermatological disorders or...
US-9,434,717 Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- ...
The present invention relates to a substantially crystalline and free solid state form of ...
US-9,434,716 Antigen binding proteins
The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such...
US-9,434,715 Benzoimidazol-2-yl pyrimidine modulators of the histamine H.sub.4 receptor
Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders,...
US-9,434,714 Pyrimidine imidazole amines as modulators of kinase activity
The invention provides novel imidazole amine compounds according to formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such...
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