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Methods for novel drug discovery, treatment and selective targeting for
gefitinib-resistant non-small-cell lung...
The present invention relates to methods for novel drug discovery, treatment and selective targeting for Gefitinib-resistant non-small-cell lung cancer (NSCLC)...
Use of psoralen derivatives and combination therapy for treatment of cell
Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif...
Quinolines as FGFR kinase modulators
The invention relates to new quinoline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the...
Methods of treating pruritic conditions mediated through non-histaminergic
mechanisms in diabetic patients
Described herein are methods of treating a mammal in need of treatment for non-histaminic pruritus by administering to the mammal in need thereof a...
Myeloid differentiation inducing agents
Myeloid differentiating agents can be used in the treatment of myeloid proliferative disorders.
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain compounds of the following formula (for...
Macrolide particulates, methods for preparation, and medical devices
The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method...
Methods for treating hyperuricemia in patients with gout using halofenate
or halofenic acid and a second...
Disclosed herein are pharmaceutical compositions, methods and kits for lowering the serum uric acid level of a subject and for the treatment of a condition...
Triazolone compounds as mPGES-1 inhibitors
The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are...
Methods employing wolbachia FtsZ as a target for albendazole sulfone
Compositions and Methods are described in which Albendazole sulfone binds to Wolbachia FtsZ providing anti filarial activity.
Tetrazolones as a carboxylic acid bioisosteres
The present disclosure provides compounds that include a tetrazolone derivative of a carboxyl group of an active agent. This disclosure also relates to...
Anti-cancer compositions and methods
Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present...
Methods for producing crosslinked flavonoid hydrogels
There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel...
Method for inhibiting the growth of bacteria
The present invention is directed to a method for inhibiting the growth of pathogenic bacteria in an infant formula comprising supplementing the infant formula...
Methods for the treatment of immune disorders
The invention features methods of treating an immune disorder characterized by elevated Pin1 marker levels in a subject by administering a retinoic acid...
3,5,3'-triiodothyronine sulfate as thyromimetic agent and pharmaceutical
The invention regards the use of triiodothyronine sulfate, commonly named T.sub.3S, as a medicament having thyromimetic activity for the treatment of...
Compounds and compositions for the treatment of cancer
New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC...
Acrylamide compounds and use thereof for inhibiting apoptosis
The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition...
Method for treating inflammation and pain
The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and .omega.-(methylsulfonyl)alkylamine or...
Treatment of urinary incontinence using nitrone spin traps
Urinary incontinence is treated by administration of pharmaceutical compositions containing at least one nitrone spin trap such as .alpha.-phenyl t-butyl...
Use of lumefantrine and related compounds in the treatment of cancer
The present application discloses the use of the anti-malarial drug lumefantrine and related compounds in the treatment of cancer.
Small molecule inhibitors of Dusp6 and uses therefor
Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and...
Method of treating microbial infections
Methods of inhibiting or preventing the proliferation of a fungus and/or a bacteria in a living organism, in water, in air, and/or on surfaces, include...
Anxiolytic effect of pterostilbene
We report for the first time that pterostilbene, a natural analog of resveratrol, shows anxiolytic-like action by downregulating phosphorylated levels of ERKs...
Food composition for nourishing, maintaining and cultivating a variety of
stem cells and a method for...
A food composition for nourishing, maintaining and cultivating a variety of stem cells, the food composition includes grape skin or polygonum cuspidatum root...
The invention relates to a transdermal therapeutic system (10) comprising an active ingredient depot (11) that contains at least one active ingredient,...
Oral film-form base and preparation
The present invention aims to provide an oral film-form base and an oral film-form preparation which have a rapid dissolution profile in the mouth and...
Method for preparing nano particles
The present invention relates to a method for manufacturing nano-scale particles of an active material. More particularly, the present invention relates to a...
Active agent microparticles
The present invention concerns polymeric-enveloped microparticles including at least one HASE type acrylic copolymer, at least one solid-liquid phase change...
Nanoshells on polymers
Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
Provided is a capsule having a shell of material that is a supramolecular cross-linked network. The network is formed from a host-guest complexation of...
Method for manufacturing a compound danshen dripping pill
A method for manufacturing a compound danshen dripping pill is disclosed. The method comprises: mixing powders of active substances with an excipient in a...
Trazodone composition for once a day administration
The invention relates to a once a day formulation of trazodone or a trazodone derivative. The formulation contains trazodone or a trazodone derivative and a...
Coating film, and granules and tablets each utilizing same
A coating film comprising ethyl cellulose as a component A and an (ethyl acrylate)-(methyl methacrylate) copolymer or a plasticized vinyl acetate polymer as a...
Solvent extraction from biodegradable microparticles
Embodiments may include a method for reducing a solvent concentration in a plurality of microparticles. The method may involve contacting a mixture including...
Pharmaceutical dosage form
This invention relates to pharmaceutical dosage forms, particularly to pH dependent pharmaceutical dosage forms with enhanced and/or prolonged distribution of a...
Phospholipid-based powders for drug delivery
Phospholipid based powders for drug delivery applications are disclosed. The powders comprise a polyvalent cation in an amount effective to increase the...
Microspheres useful for therapeutic vascular embolization
Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer...
Various fenofibrate dosage forms contain a plurality of beads or particles, where the beads or particles include a pharmaceutical composition comprising...
Adjuvant incorporation in immunoanotherapeutics
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable...
Temperature sensitive liposome including cationic lipid and use thereof
Provided are a liposome including a cationic lipid, a pharmaceutical composition for the delivery of anionic drugs, and a method for delivering anionic drugs to...
Foam containing benzoyl peroxide
The present invention relates to foamable compositions for treating acne comprising benzoyl peroxide; to a therapeutic kit comprising such compositions; and to...
Method of preparing composition for delivering an anionic drug
Disclosed is an effective method of preparing a composition for delivering an anionic drug, the composition comprising an anionic drug as an active ingredient,...
Methods and compositions for treating conditions related to lack of blood
supply, shock and neuronal injuries
A pharmaceutical composition comprising an amphiphilic emulsifier, a polar liquid carrier and, optionally, a lipid component. The amphiphilic emulsifier form...
Liquid pharmaceutical formulations of palonosetron
The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron....
Form of administration of enkephalinase inhibitor
The present invention relates to a new formulation of an enkephalinase inhibitor, such as racecadotril or dexecadotril, the process for the preparation thereof,...
Methods of delivering pharmaceutical agents
Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological...
Gastric retention system
The present invention provides a novel gastric retention system in the form of a tablet or a capsule coated with an expandable coating, more particularly, with...
Use of pufas for treating skin inflammation
The present invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I), ##STR00001## or a pharmaceutically...
Composition for preventing or alleviating skin wrinkles containing
honeybush extract or fermented honeybush as...
Provided is a composition for preventing or alleviating skin wrinkles containing honeybush (Cyclopia intermedia) extract, a fraction thereof, or a fermented...