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Patent # Description
US-9,441,010 Method for selective derivatization of oligohistidine sequence of recombinant proteins
Methods and compositions for the selective derivatization of a oligohistidine-tagged recombinant protein. A modifying compound comprised of an imidazole...
US-9,441,009 Co-modified organopolysiloxane, and powder treatment agent and powder composition comprising the same
A co-modified organopolysiloxane having a group having a siloxane dendron structure and a group containing a saccharide component (e.g. a sugar lactone amide...
US-9,441,008 3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of...
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as described herein, and their prodrugs or...
US-9,441,007 Substituted nucleosides, nucleotides and analogs thereof
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs...
US-9,441,006 Polymorph of 2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine
The invention relates to a compound which is, 2-[4-[(methylamino)carbonyl]-1H-pyrazol-1-yl]adenosine, which is a selective A2A adenosine receptor agonist in...
US-9,441,005 Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof,...
US-9,441,004 Purification of staphylococcus aureus type 8 capsular saccharides
The invention provides a method for releasing capsular polysaccharide from S. aureus type 5 or type 8 cells, comprising the step of treating the cells with...
US-9,441,003 Membrane staining dyes containing phosphorescent transition metal polypyridine complexes
The present invention is concerned with a staining dye for staining a biological cell, comprising dye molecules with a positively charged polar head group for...
US-9,441,002 Dithiolane based thiol modifier for labeling and stronger immobilization of bio-molecules on solid surfaces
The thiol modified oligonucleotides have vast number of applications in the field of nucleic acid chemistry. The conjugates generated by mono thiol groups are...
US-9,441,001 Method of making hydroxymethylphosphonate, polyurethane foam-forming compositions, polyurethane foam and...
There is provided herein a method of making hydroxymethylphosphonate comprising reacting paraformaldehyde, at least one dialkyl phosphite and at least one...
US-9,441,000 Use of metallocene compounds for cancer treatment
Metallocene compounds and pharmaceutical compositions containing these metallocene compounds are disclosed and described. Methods of treating cancer employing...
US-9,440,999 Activation of metal salts with silylhydrides and their use in hydrosilylation reactions
The invention relates generally to transition metal salts, more specifically to iron, nickel, cobalt, manganese and ruthenium salts, activated with...
US-9,440,998 Process for preparing urea-containing mercaptosilanes
The invention relates to a process for preparing urea-containing mercaptosilanes of the general formula I ##STR00001## wherein a chlorosilane of the general...
US-9,440,997 Hydrolysable silanes
This invention relates to hydrolysable silanes useful in the modification of elastomers, and as coupling agents for diene elastomer compositions containing a...
US-9,440,996 Alpha-alkoxysilane-terminated prepolymer for fast-curing spray foams with improved propellant gas solubility
The present invention relates to an alpha-alkoxysilane-terminated prepolymer preparable by reaction of at least one polyether polyol, of a polyisocyanate and of...
US-9,440,995 Arginase inhibitors as therapeutics
Compounds according to Formula I are potent inhibitors of Arginase I and II activity: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, D, W, X, Y, and Z...
US-9,440,994 Boron containing small molecules as antiprotozoal agents
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as...
US-9,440,993 Small molecule inhibitors of TRPA1
The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be...
US-9,440,992 5,7-disubstituted thiazolo[4,5-D]pyrimidines as chemokine inhibitors
There are disclosed novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5...
US-9,440,991 Synthesis of an antiviral compound
The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## which is useful as an antiviral agent. The disclosure...
US-9,440,990 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The...
US-9,440,989 Antifibrinolytic compounds
It relates to spirocyclic compounds of formula (I), or pharmaceutically or veterinary acceptable salts thereof, or any stereoisomers either of the compounds of...
US-9,440,988 Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the...
US-9,440,987 Aromatic ring compound
The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the...
US-9,440,986 Crystalline, anhydrous forms of oxymorphone hydrochloride
Crystalline, anhydrous hydrochloride salts of 4,5.alpha.-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms...
US-9,440,985 Tricyclic derivatives of N,N'-substituted 3,7-diazabicyclo [3.3.1]nonanes and drugs based thereon
The invention relates to novel 3,6,9-triazatricyclo[7.3.1.1]tetradecane-4,8,12-trione derivatives of general formula (1), which act as allosteric AMPA receptor...
US-9,440,984 Pyrrolotriazines as ALK inhibitors
This application provides compounds of the general formula (I) ##STR00001## and/or a salt thereof, where X, R.sup.1 and R.sup.2 are as defined herein....
US-9,440,983 Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione derivatives
This invention relates to novel Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione derivatives of Formula (I): ##STR00001## and their use as TRPC5 modulators,...
US-9,440,982 Substituted prolines/piperidines as orexin receptor antagonists
The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX.sub.1 or OX.sub.2, or both; to pharmaceutical...
US-9,440,981 Pyrrolo[2, 1-F] [1,2,4]triazine derivative and use thereof for treating tumors
Disclosed are a pyrrolo[2,1-f][1,2,4]triazine derivative of Formula (I) and use thereof for treating tumors. The compound has remarkable antiproliferative...
US-9,440,980 Remedy for diabetes
A method of screening a compound having a hypoglycemic effect (hereinafter referred to as "hypoglycemic compound"), a remedy for diabetes which contains a...
US-9,440,979 Process for the preparation of pralatrexate
An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful...
US-9,440,978 Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and...
US-9,440,977 Compositions, uses and methods for their preparation
The present invention relates to novel compounds and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various...
US-9,440,976 1,7-diazacarbazoles and methods of use
The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as...
US-9,440,974 Kinase inhibitors
Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the...
US-9,440,973 Pyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione derivatives
This invention relates to novel Pyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione derivatives of Formula (I): ##STR00001## and their use as TRPC5 modulators,...
US-9,440,972 Pyrido[2,3-d]pyrimidine-2,4(1 H,3H)-dione derivatives
This invention relates to novel Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives of Formula (I): ##STR00001## and their use as TRPC5 modulators,...
US-9,440,971 Solid state forms of vemurafenib hydrochloride
Provided herein are solid state forms of Vemurafenib hydrochloride, processes for preparing the solid state forms, as well as pharmaceutical compositions and...
US-9,440,970 Pyrazole derivative
It has been desired to develop a pharmaceutical composition, which is used in agents for preventing and/or treating various diseases related to PDE10 (e.g....
US-9,440,969 Compounds and methods for kinase modulation, and indications therefor
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and...
US-9,440,968 Substituted pyrido[3,2-d]pyrimidines for treating cancer
Novel azaquinazoline carboxamide derivatives of formula (I) ##STR00001## wherein W.sup.1, W.sup.2, W.sup.3, W.sup.4, R.sup.1, R.sup.2, R.sup.3 and m which are...
US-9,440,967 1H-pyrrolo [2, 3 -B] pyridine derivatives and their use as radical quenchers
The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these...
US-9,440,966 Compounds for treatment of metabolic syndrome
Present invention refers to new compounds of formula I or II, its synthesis and its use in the treatment of metabolic syndrome, particularly for the treatment...
US-9,440,965 Process for the synthesis of benzothiadiazole compounds
The invention relates to a significantly improved process for the preparation of benzothiadxazole compounds which can be used in the production of Luminescent...
US-9,440,964 Pesticidal compositions and processes related thereto
This document discloses molecules having the following formula ("Formula One") ##STR00001## The molecules disclosed in this document are related to the field...
US-9,440,963 Compositions, formulations and methods for treating ocular diseases
Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions...
US-9,440,962 Benzisoxazoles
The present invention relates to compounds of general formula ##STR00001## wherein Ar.sup.1/Ar.sup.2 are phenyl or a 5 or 6-membered heteroaryl;...
US-9,440,961 Rho-kinase inhibitors and method of preparation
The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such...
US-9,440,960 Substituted oxetanes and their use as inhibitors of cathepsin C
This invention relates to a compound of formula I ##STR00001## and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same,...
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