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Patent # Description
US-9,440,959 Process for the preparation of nilotinib
The present invention relates a process for the preparation of a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, which...
US-9,440,958 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
The present invention provides compounds of the formula I: ##STR00001## its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline...
US-9,440,957 Compounds and compositions for modulating EGFR Activity
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating EGFR activity, as well as methods for using such...
US-9,440,956 Indole, indazole and benzimidazole arylamides as P2X.sub.3 and P2X.sub.2/3 antagonists
Compounds of the formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein, X, Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are...
US-9,440,955 Crystal form
A novel crystalline form of a compound is disclosed.
US-9,440,954 Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols according to formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.
US-9,440,953 Substituted amino triazoles useful as acidic mammalian chitinase inhibitors
Disclosed are amino triazole compounds substituted by a carboxylate functional group or an bioisosteric polar functional group. Compounds having the carboxylate...
US-9,440,952 Compounds inhibiting leucine-rich repeat kinase enzyme activity
The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in...
US-9,440,951 Quinolone compound
The present invention provides a compound represented by the formula (I) ##STR00001## wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or...
US-9,440,950 Arginine methyltransferase inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein...
US-9,440,949 Diacylglycerol acyltransferase 2 inhibitors
Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in...
US-9,440,948 Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use
Embodiments of the present disclosure provide for compounds such as those shown in FIG. 1.1 (compounds A, B, C, and D), 2'substituted nicotine compounds,...
US-9,440,947 Regeneration of selective solvents for extractive processes
Recovering a polar hydrocarbon (HC) selective solvent substantially free of hydrocarbons (HCs) and other impurities from a lean solvent stream containing the...
US-9,440,946 N-phenethylcarboxamide derivatives
A compound of general formula (I): ##STR00001## A process for preparing this compound. A fungicidal composition comprising a compound of general formula (I)....
US-9,440,945 Methods for the synthesis of tiotropium bromide
Present invention relates to methods for preparing (1.alpha., 2.beta., 4.beta., 5.alpha., ...
US-9,440,944 Production of cyclic acetals or ketals using solid acid catalysts
A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction...
US-9,440,943 Tricyclic sulfone compounds and methods of making and using same
The invention provides tricyclic sulfone compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of...
US-9,440,942 Chroman-derived anti-androgens for treatment of androgen mediated disorders
Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by...
US-9,440,941 Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals
The present invention relates to substituted chroman-6-yloxy-cycloalkanes of the formula (I) in which Ar, R1 to R4, p and q are as defined in the claims. The...
US-9,440,940 Methods for synthesis of psoralen derivatives
Methods for the synthesis of psoralen derivatives are provided. In one embodiment, the method may include acetylating a compound of formula (II) to form a...
US-9,440,939 Norbornene derivative
A novel compound useful as a raw material for a resist material is described. A norbornene derivative having epoxy and a methylene-mediated reactive group in a...
US-9,440,938 Sulfonamide derivative having PGD2 receptor antagonistic activity
The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound...
US-9,440,937 Method for producing polyisocyanates and use thereof
The invention relates to a method for modifying isocyanates using catalysts having a water content not exceeding 1,000 ppm.
US-9,440,936 Synthesis of 3,4-Bis(4-nitro-1,2,5-oxadizaol-3-yl)-1,2,5-oxadizaole-N-oxide (DNTF) using...
A novel method for preparing 3-chlorocarbohydroxymoyl-4-nitro-1,2,5-oxadiazole by reacting 4-amino-3-chlorocarbohydroxymoyl-1,2,5-oxadiazole with H.sub.2O.sub.2...
US-9,440,935 Process for producing 2-phenyl-1,3-benzoxazoles
The present invention relates to a novel method for producing 2-phenyl-1,3-benzoxazoles of formula (I). ##STR00001##
US-9,440,934 Synthesis of copper(I) 5-nitrotetrazolate
A method of manufacture of the primary explosive material copper(I) 5-nitrotetazolate (DBX-1) by a synthesis starting with 5-aminotetrazolate (5-AT); wherein,...
US-9,440,933 Azole derivative, method for producing same, intermediate compound, and agricultural or horticultural chemical...
Provided is an azole derivative superior in disease-controlling activity contained as an active ingredient in agricultural or horticultural chemical agents. The...
US-9,440,932 Phase-transfer catalysed formation of N-(substituted phenyl) sulfonamides in water
A new process for making agrochemically important N-[2,4-dichloro-5-[4-(difluoro methyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl] ...
US-9,440,931 Form-III crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsu- ...
Form-III crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsu- lfonyl)acetamide and a method of producing the crystal are...
US-9,440,930 Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
Substituted bicyclic dihydropyrimidinones of formula 1 ##STR00001## and their use as inhibitors of neutrophil elastase activity. An exemplary compound is ...
US-9,440,929 Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
The present invention discloses compounds according to Formula I: ##STR00001## wherein Cy, R.sup.1, L.sub.1, R.sup.3, R.sup.4, R.sup.5, L.sub.a, and R.sup.a...
US-9,440,928 Process for the synthesis of N-substituted cyclic alkylene ureas
The invention relates to a process for the synthesis of N-substituted cyclic alkylene ureas by reacting a multifunctional aliphatic amine A having at least two...
US-9,440,927 Process for preparation of substituted 3'-hydroazino-diphenyl-3-carboxylic acid compounds
The present invention provides a process for the preparation of substituted 3'-hydrazino-biphenyl-3-carboxylic acid compounds. The present invention further...
US-9,440,926 Antiviral compounds and methods
The present invention relates to novel compounds and compositions having antiviral activity. The invention also relates to methods for the therapeutic or...
US-9,440,925 SDP-containing heterobifunctional agents
The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester...
US-9,440,924 Acetone solvate of ivabradine hydrochloride
The present invention relates to a novel solvate of ivabradine hydrochloride, a process of its preparation and its use for the preparation of specific...
US-9,440,923 Process for the preparation of 4,5,6-trichloropicolinic acid
4,5,6-Trichloropicolinic acid is prepared by selectively dechlorinating 3,4,5,6-tetrachloropicolinic acid with zinc and a catalyst prepared from a nickel...
US-9,440,922 Tetracyclic compound
A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or...
US-9,440,921 3-N-butyl-1-isoindolinone and use thereof for preventing or treating cerebral infarction
3-n-Butyl-1-isoindolinone and use thereof for preventing or treating cerebral infarction. The compound is prepared by: 1) employing phthalimide as a starting...
US-9,440,920 Antimicrobial compounds, compositions and methods of use thereof
Described herein are antimicrobial compounds identified via a high-throughput screen to identify compounds that produce anucleate cells in E. coli after cell...
US-9,440,919 Difluorolactam compositions for EP4-mediated osteo related diseases and conditions
Disclosed herein are compositions and methods of treating osteoporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of...
US-9,440,918 Method for purifying (S)-Oxiracetam
A method for purifying (S)-oxiracetam is disclosed. Crude (S)-oxiracetam with the purity of 89% is dissolved in water; the solution is allowed to stand for 1 to...
US-9,440,917 Method for producing 4-haloalkyl-3-mercapto-substituted 2-hydroxy-benzoic acid derivatives
A process is described for preparing 4-haloalkyl-3-mercapto-substituted 2-hydroxybenzoic acid derivatives of the general formula (I) by reaction of...
US-9,440,916 3, 4-bis-benzylsulfonylbutyronitrile and its pharmaceutical use
The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method...
US-9,440,915 Method for preparing methanedisulfonic acid
Disclosed is a method for preparing methanedisulfonic acid, comprising an acidification, wherein the acidification comprises that methanedisulfonate reacts with...
US-9,440,914 Method for treating glioblastomas and other tumors
Methods of treating an astrocytoma with agents effective to inhibit microglia function are provided, as well as methods of enhancing the efficacy of brain tumor...
US-9,440,913 Dihydroxybenzene derivatives and antiprotozoal agent comprising same as active ingredient
Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) ##STR00001## ...
US-9,440,912 Pentenenitrile isomerization
Disclosed is a process for isomerizing cis-2-pentenenitrile to 3-pentenenitrile in the presence of a non-aluminum metal oxide catalyst, wherein: (a) the metal...
US-9,440,911 Multifunctional primary amine, process for its preparation, and use thereof
The invention relates to a hydrophilically modified multifunctional amine AC which has more than one primary amino group per molecule, and at least one group...
US-9,440,910 Reference markers for fesoterodine fumarate
The present invention relates to the new impurities of Fesoterodine, Fesoterodine symmetric dimer impurity and asymmetric dimer impurity, process for preparing...
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