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Curcumin-antibody conjugates as anti-cancer agents
The invention relates to curcumin derivatives having the formula I: wherein: Z represents: H.sub.3CO A represents --CH.sub.2--CH.sub.2-- or --CH.dbd.CH--; L...
Glycopeptide and uses thereof
A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also...
Influenza antigen delivery vectors and constructs
The present invention relates to fluorocarbon vectors for the delivery of influenza antigens to immunoresponsive target cells. It further relates to...
Polymer chelator conjugates
Provided herein are biocompatible polymer conjugates comprising a biologically compatible polymer covalently bound to a biologically compatible chelator moiety,...
Methods of producing cancer compounds
Provided herein are methods of making the compound of Formula I: ##STR00001## and certain intermediates involved in such process.
MetAP-2 inhibitor polymersomes for therapeutic administration
The present invention provides methods to treating inflammation related disease and disorders such as an autoimmune disease and autoimmune related uveitis by...
Polymer-based compositions and conjugates of HIV entry inhibitors
Provided herein are water-soluble polymer conjugates and polymer-based compositions of HIV entry inhibitors. Also provided are methods for synthesizing and...
Dual acting prodrugs
A prodrug is provided which includes at least two different pharmaceutically and/or diagnostically active compounds independently bound by cleavable linkers and...
Composite particles which contain both cellulose and inorganic compound
Provided are composite particles which exhibit excellent fluidity and high liquid retentivity and which exhibit high fluidity even in a liquid-holding state....
Modified hyaluronic acid polymer compositions and related methods
The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled...
Risperidone sustained release microsphere composition
A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof,...
Stabilizing alkylglycoside compositions and methods thereof
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity,...
Dry powder inhaler and system for drug delivery
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a...
Diether based biodegradable cationic lipids for siRNA delivery
Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid...
Topical compositions and methods for making and using same
The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof.
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I...
Multi-layered structure for drug reservoir and drug eluting stent
including the same
Disclosed is a multi-layered structure for drug reservoir, comprising a first micelle layer for crosslinking and adhesion, comprising a drug, a multi-arm...
Composition comprising egg white combined chalcanthite for preventing or
The present invention relates to a composition comprising an egg white combined chalcanthite component for preventing or treating cancer, and more particularly,...
Compositions including androgen receptor degradation (ARD) enhancers and
methods of prophylactic or therapeutic...
The present invention includes methods and compositions useful for treating and preventing skin disorders, hair loss and other skin disorders. The compositions...
Thermal treatment of acne with coated metal nanoparticles
Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic...
Anti-EphA2 antibodies and methods of use thereof
Antibodies that bind to tumor associated antigen CD44 or to tumor associated antigen EphA2, are disclosed herein, as well as related compositions and methods of...
Targeting of bone marrow neovasculature
Antibodies which bind an antigen of the bone marrow neovasculature in leukemia patients, for use in treatment and diagnosis of leukemia, in particular the...
Multimeric complexes with improved in vivo stability, pharmacokinetics and
The present invention concerns multimeric complexes based on antibody fusion proteins comprising an AD moiety attached to the C-terminal end of each antibody...
Use of GK-1 peptide expressed on M13 filamentous phage as pharmaceutical
ingredient to enhance the efficiency...
The present invention is directed to the use of FGK-1 immunopotentiator, composed by the peptide named GK-1, characterized by the sequence ...
Cloning of honey bee allergen
The present invention relates to a recombinant polypeptide capable of binding to IgE from subjects allergic to venom of an insect from the order Hymenoptera...
The present invention provides a therapeutic or improving agent for a lifestyle-related disease, containing an expression vector encoding a chimeric Hepatitis B...
Vaccinia virus polypeptides
This document provides methods and materials related to polypeptides present in a vaccinia virus (e.g., membrane proteins such as vaccinia virus B5R, L1R, A33R,...
Newcastle disease virus vectored herpesvirus vaccines
The present invention encompasses recombinant Newcastle Disease Virus-Herpesvirus vaccines or compositions. The invention encompasses recombinant NDV vectors...
Rotavirus subunit vaccines and methods of making and use thereof
The present invention provides Rotavirus antigenic polypeptides or antigens that elicit an immune response in animal or human against rotavirus, compositions...
Peptide sequences and compositions
Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID...
Methods of stimulating immunity employing dengue viral antigens
Compositions that include at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one member selected from...
Cross-protective arenavirus vaccines and their method of use
The invention relates to DNA vaccines that target multiple arenavirus agents singly or simultaneously.
Bacterial live vector vaccines expressing chromosomally-integrated foreign
Bacterial live vector vaccines represent a vaccine development strategy that offers exceptional flexibility. In the present invention, genes encoding protective...
Clostridium difficile DNA vaccine
The invention relates to compositions and methods for treating C. difficile associated disease (CDAD) through the administration to a subject in need thereof at...
Inactivated bacterial cell formulation
The invention relates to the use of lactic acid-producing bacteria to boost the immune system.
Vaccine candidates against Johne's disease
A composition and method for immunizing a mammal infected with Mycobacterium are disclosed. The genes gcpE, pstA, kdpC, papA2, impA, umaA1, fabG2_2, aceAB,...
Glycoconjugates and their use as potential vaccines against infection by
A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
The present invention relates to novel compositions for medical use, particularly for use as vaccines. The present invention relies upon the dependence of the...
Scaffolds for cell transplantation
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold...
NEIL3 peptides and vaccines including the same
The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 45, which bind to an HLA antigen and induce cytotoxic T lymphocytes...
Chimeric antigen receptor specific for folate receptor .beta.
The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML). The invention also relates to at least one...
Method of inducing a proinflammatory immune response to human
Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising...
Free-standing biodegradable patch
Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative...
Polypeptides having alpha-glucuronidase activity and polynucleotides
The present invention relates to isolated polypeptides having alpha-glucuronidase activity, catalytic domains and polynucleotides encoding the polypeptides,...
Agent for use in the case of fructose intolerance
5-D-fructose dehydrogenase, optionally in combination with invertase and/or maltase and/or glucose isomerase, may be used to treat fructose intolerance. Other...
Dietary supplements and formulations
Provided are dietary supplements, formulations, kits and methods for administration to an individual with type II diabetes or at risk of developing type II...
Method for brain cancer therapy by co-administration of a parvovirus and
Described is a pharmaceutical composition comprising (a) a parvovirus and (b) a cytokine, preferably IFN-.gamma., and the use of said composition for treatment...
Composition for controlled release of physiologically active substance
A composition for controlled release of a physiologically active substance can release a physiologically active substance in vivo at the desired timing. The...
Methods for treating metabolic disorders using FGF
The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance,...
Glypican-4 based compositions and methods for treating and diagnosing
Provided herein are methods for increasing insulin sensitivity in a subject. A method may comprise administering to a subject in need of increased insulin...