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Methods of using selective chemotherapeutic agents for targeting tumor
A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is...
DYRK1 inhibitors and uses thereof
The present invention relates to novel thiazolo[5,4-f]quinazoline compounds and methods that are useful in the amelioration, treatment or control of Down's...
A pharmaceutical combination comprising (a) a protein kinase C (PKC) inhibitor compound, or a pharmaceutically acceptable salt thereof, and (b) at least one...
This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from...
Method of treatment
The present invention relates to a method of treating T cell mediated inflammatory immune diseases or T cell mediated hypersensitivity diseases, which comprises...
Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are...
Aminoheteroaryl compounds as MTH1 inhibitors
The present invention relates to an (S)-enantiomer of an aminoheteroaryl compound for use in treating and/or preventing cancer in a subject. The invention...
Method and composition for treating a serotonin receptor-mediated
A method and composition for treating serotonin receptor-mediated conditions.
Methods for the treatment of parkinson's disease psychosis using
Methods for the treatment of Parkinson's disease psychosis which comprise the administration of pimavanserin.
Compositions of a polyorthoester and an aprotic solvent
Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an aprotic solvent, and a drug are described. The solvent is selected to...
1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
Provided herein are compounds according to Formula I and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various...
Pyrazolylaminopyridines as inhibitors of FAK
The present invention relates to a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3,...
Pharmaceutical composition including migratory factor for guiding
pluripotent stem cells to injury
The purpose of the present invention is to identify a migratory factor that guides pluripotent stem cells (Muse cells) useful in new medical applications to...
Methods for treating cardiovascular disorders
There is provided a once-a-day therapeutically synergistic pharmaceutical dosage form for treatment of cardiovascular disorders, wherein the dosage form...
Compositions and methods for neovascularization
The invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an...
Methods and pharmaceutical compositions for the treatment of symptoms of
anxiety and panic using beta...
The present invention is focused primarily toward pro re nata ("as needed") treatments for a psychiatric condition or disorder or the symptoms thereof,...
Use of NK-1 receptor antagonists in management of visceral pain
Methods for managing visceral pain in mammalian subjects are described, in which a NK-1 receptor antagonist is administered to the subject before, during or...
Methods of increasing tonic inhibition and treating fragile X syndrome and
Methods of increasing tonic inhibition in a subject in need thereof, for example a subject with Fragile X syndrome or Angelman syndrome are disclosed. Methods...
Use of pidotimod to treat irritable bowel syndrome
The present invention is directed to the use of pidotimod, or a physiologically acceptable salt thereof, to treat irritable bowel syndrome. For the treatment of...
Ocular formulations for drug-delivery to the posterior segment of the eye
The present invention relates to topical formulations comprising a compound of the following formula: ##STR00001## for treating ocular neovascularization. The...
Treatment or prevention of hypotension and shock
The present invention relates to a method for the prevention and treatment of hypotension and shock due to low peripheral resistance, comprising administering...
Formulations for the treatment of vaginal disorders
The present disclosure provides novel formulations suitable for the intravaginal delivery of tinidazole, as well as methods of using the same.
Methods and compositions involving (S)-bucindolol
Disclosed is bucindolol substantially free of its R-stereoisomer. Also disclosed are pharmaceutical compositions that include bucindolol substantially free of...
This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and...
Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and
acridine and uses thereof
Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures,...
Methods for Alzheimer'S disease treatment and cognitive enhancement
The present invention relates to compositions and methods to modulate .alpha.-secretase and/or to improve cognitive ability. The invention further relates the...
Sparstolonin B based pharmaceutical agent for neuroblastoma treatment
Use of sparstolonin B in inhibition of growth and/or viability of human neuroblastoma cells is described. The sparstolonin B can be naturally derived from the...
Pharmaceutical composition for treating or preventing angina or myocardial
infarction induced by myocardial...
The present invention provides a pharmaceutical composition for the treatment and prophylaxis of angina and myocardial infarction, wherein a combination of a...
Compositions and methods for treating herpes simplex virus
Green tea polyphenol compositions and methods of their use in treating herpes simplex virus (HSV) are provided. Representative green tea polyphenols include,...
Methods of treating age related disorders
The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The...
Quinone based nitric oxide donating compounds for ophthalmic use
The present invention relates to novel nitric oxide donor compounds for the use in the treatment and/or prophylaxis of hypertensive glaucoma, normotensive...
Composition for improving membrane composition and functioning of cells
It has now been found that after administration to a diseased person or person that is at risk for developing such disease of a neutraceutical or pharmaceutical...
Method of lowering circulating oxidized low density
lipoprotein-beta-2-glycoprotein 1 complex for treatment of
Embodiments of the invention comprise methods of reducing circulating oxidized low density lipoprotein-beta-2-glycoprotein 1 and circulating Myeloperoxidase...
This invention relates to novel substituted nitrocatechol derivatives, their use in the treatment of some central and peripheral nervous system disorders and...
Anticonvulsant combination therapy
The present invention is directed to a pharmaceutical composition comprising a Compound (a) of a class of peptide Compounds and at least one further Compound...
Compounds and methods for treating aberrant adrenocortical cell disorders
Methods and compositions are provided for treatment of disorders associated with aberrant adrenal cortex cell behavior, including (but not limited to) treatment...
Methods for treating conditions of the nail unit
The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of...
Semisolid aqueous pharmaceutical composition containing tapentadol
A semisolid aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof.
Methods for maintaining or improving health, well-being and/or a
physiological function in a subject
The invention relates to a method of treating or preventing a condition in a subject, comprising administering to the subject an acceptable composition...
Hydroxytyrosol combinations for enhancing mitochondrial function and
Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine,...
Methods for improving tolerance, digestion, and lipid soluble nutrient
absorption in an infant, toddler, or child
Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving...
Transdermal nicotine salt delivery system
A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric...
Prion free nanoparticle compositions and methods of making thereof
The present invention provides prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs. Also provided are...
Spheroids and multiparticulate tablets comprising them
The invention relates to a directly-compressible gastro-resistant spheroid. The spheroid comprises: (i) a core containing one or more active substances; (ii) a...
Increasing drug affinity for crystalline microparticle surfaces
Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to...
Cellulosic gel material as a pharmaceutical excipient
A method of making a pharmaceutical tablet comprises (a) combining (i) an aqueous networked cellulose gel with (ii) filler and (iii) an active agent to form a...
Process for preparing carrier particles for dry powders for inhalation
Carrier particles in which at least 60% of the surface is coated with magnesium stearate are useful for preparing dry powder formulations for inhalation.
Pharmaceutical dosage forms comprising a low-solubility drug and a polymer
A dosage form comprises a low-solubility drug, and a precipitation-inhibiting polymer. The drug is in a solubility-improved form and in the form of particles at...
Microcapsules comprising a fat-soluble active substance
The invention relates to microcapsule comprising at least one fat-soluble active substance selected from provitamins, vitamins and esters thereof, ...
Extended production of nitric oxide from a microencapsulated nitrite salt
and an aqueous acidified gel
Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of a least one...