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Regulation of specific spinal neurons regulating pain transmission via
A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain,...
Method for the biocatalytic cyclization of terpenes and cyclase mutants
The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular...
Enolase peptide conjugate vaccines against Staphylococcus aureus
The present invention relates to peptides of the enolase protein from Staphylococcus aureus as well as nucleic acid and nucleic acid sequence homologs encoding...
Method for producing recombinant prothrombin, vector DNA, and reagent kit
The present invention provides a method for producing recombinant prothrombin. The method comprises: providing a vector DNA into which a gene encoding a tag and...
PH20 polypeptide variants, formulations and uses thereof
Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also...
Beta-glucosidase I variants with improved properties
The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase...
Polypeptides having cellobiohydrolase I activity and polynucleotides
The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the...
Heterologous expression of fungal cellobiohydrolase 2 genes in yeast
The present invention provides for heterologous expression of polypeptides encoded by wild-type and codon-optimized cbh2 genes from the organisms Cochliobolus...
Glucoamylase variants with altered properties
The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In...
Method for accumulating protein in plant cells
According to the present invention, a method for stably accumulating a target protein in plant cells or a plant body, and a transgenic plant in which protein...
Methods and products for expressing proteins in cells
The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to...
Methods and compositions for treatment of myotubular myopathy using
chimeric polypeptides comprising...
The present invention provides chimeric polypeptides comprising myotubularin 1 (MTMI) polypeptides and an internalizing moiety, wherein, the moiety can be an...
Phosphatidic acid phosphatase gene
The present invention provides a novel phosphatidic acid phosphatase gene. The object of the present invention can be solved by providing a nucleic acid...
DFPase enzymes from aplysia californica
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The...
Diagnostic tests for the detection of inherited peripheral neuropathies
The disclosure relates to the field of human genetics, particularly the field of peripheral neuropathy, particularly inherited peripheral neuropathy....
Aldehyde tags, uses thereof in site-specific protein modification
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a...
Modified polymerases for improved incorporation of nucleotide analogues
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3' position of the...
Provided are various novel DNA polymerases. Provided is a DNA polymerase comprising an amino acid sequence modified from the amino acid sequence of SEQ ID NO: 8...
Modified forms of pseudomonas exotoxin A
Pseudomonas exotoxin A or "PE" is a 66kD, highly potent, cytotoxic protein secreted by the bacterium Pseudomonas aeruginosa. Various forms of PE have been...
DGAT genes for increased seed storage lipid production and altered fatty
acid profiles in oilseed plants
Transgenic oilseeds having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of...
Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
From a bacterial strain isolated from an environmental sample, after enrichment in medium containing 1-butanol as the carbon source, a new enzyme with butanol...
Modified arsenite oxidase and a biosensor for detecting arsenite
The present invention provides an arsenite oxidase enzyme modified to prevent translocation by modification of a translocation signal sequence. A microorganism...
MDCK-derived cell lines adapted to serum-free culture and suspension
culture and method for preparing vaccine...
Disclosed is a Madin-Darby canine kidney (MDCK)-derived cell line. The MDCK-derived cell line is derived from MDCK cells deposited under accession number ATCC...
Generation of induced pluripotent stem cells from small volumes of
Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may...
Hydrogel-based vascular lineage cell growth media and uses thereof
A medium for growing vascular lineage cells is described. The vascular lineage cell growth medium includes an oligosaccharide-based hydrogel and a growth factor...
Non-static suspension culture of cell aggregates
The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are...
Derivation of hematopoietic cells from adult mesenchymal stem cells
Methods and compositions for differentiating tissue resident multipotent mesenchmal stromal cells (MSCs) such as adipose tissue resident MSCs into a...
Method for differentiating human embryonic stem cells into .beta.-cells
for the treatment of type I diabetes
The invention provides inter alia methods for differentiating embryonic stem cells into insulin producing cells, as well as compositions comprising such cells,...
Endodermal cells from pluripotent cells
The present inventions describes a method that, starting from pluripotent cells, leads to the obtainment, in a reproducible and efficient manner, of endodermal...
Dried spore germinative compound mixtures
In one aspect, the present invention is directed to a dried intimate mixture comprising a bacteria spore and a germinative compound, and methods for preparing...
Methods for treating a culture of Haematococcus pluvialis for lysis using
Methods of treating lysis in cultures of Haematococcus pluvialis with hydrogen peroxide are described herein. The method comprises dosing the culture comprising...
Methods for preventing a chytrid infection in a culture of Haematococcus
pluvialis using hydrogen peroxide
Methods of treating contamination, particularly fungal contamination, in cultures of Haematococcus pluvialis with hydrogen peroxide are described herein. The...
Methods for treating a culture of haematococcus pluvialis for
contamination using salt and hydrogen peroxide
Methods of treating contamination, particularly fungal contamination, in cultures of Haematococcus pluvialis with hydrogen peroxide and salt are described...
Detector arrangement for blood culture bottles with colorimetric sensors
A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or...
Holder for culture plates with de-nesting feature
A holding structure for holding a plurality of culture plates in a stacked arrangement includes a feature for de-nesting the bottom culture plate from the plate...
Distilled liquors and spirits having the fresh and natural fragrance of
shiso and processes for producing the same
Provided are liquors or spirits that compensate for the oily and grass-like smell of perillaldehyde, the primary aroma component of Perilla frutescens var....
Method and apparatus for making soap
The present invention is directed towards a method and apparatus for making soap. According to one embodiment, a soap making apparatus comprises a water vessel...
Detergent composition with low foam and high nickel solubility
A detergent composition comprising ethylene oxide/propyleneoxide (EO/PO), sodium-2-ethylhexyliminodipropionate, potassium hydroxide, hydroxyethylene...
Alkaline cleaner comprising a ternary combination of complexing agents
The invention concerns a machine cleaner to clean kitchen appliances, comprising an alkaline system and a complexing component to bind metals or metallic...
Organic cleaning composition
Organic cleaner/detergent compositions, formulations and solutions, and methods of cleaning using such compositions, formulations and solutions and...
Enhanced cleaning process of chamber used plasma spray coating without
A method including immersing a ceramic coated article into a bath including an HF acid solution having NH.sub.4F with a molar concentration of about 0.1M to...
A method of providing a fragrant odor to an application, comprising the addition thereto of at least one compound of the formula I ##STR00001## wherein X and Y...
The present invention relates to compositions comprising polyaspartic acid (PAS) derivatives and the use of said compositions in washing processes, especially...
Provided are a compound and a fragrance composition containing the same, wherein the compound has a spicy tone that is useful as a fragrance, particularly a...
Use of at least one coproduct from the vegetable oil refining industry for
obtaining a purified total...
The present invention relates to the use of at least one vegetable oil refining industry by-product to obtain a purified total unsaponifiable of vegetable oil...
Removal of undesired components from oil compositions
The present invention refers to a process for reducing the amount of undesired components in an oil composition, particularly in an oil composition comprising...
The invention provides a lubricating oil composition comprising: a lubricating base oil having a kinematic viscosity at 100.degree. C. of 1-10 mm.sup.2/s, a %...
Lubricant composition for internal combustion engine oil
The present disclosure relates to a lubricating oil composition containing a base oil, a thioheterocyclic compound represented by the formula:...
Lubricating composition and method for the preparation thereof
The invention relates to lubricating compositions and methods for producing same. The lubricating composition comprises a lubricating medium and the product of...
Diesel fuel with improved ignition characteristics
Dihydrocarbyl diazene dicarboxamides (DHCDD) have been found to effectively reduce the ignition delay and/or as effective cetane number improvers in diesel...