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Nucleic acids encoding a house dust mite allergen, Der p III, and uses
Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity...
Modified Bacillus thuringiensis cry proteins that inhibit coleopterans
The present invention includes domain I modifications that improve various attributes of various Coleopteran-active Cry proteins. These attributes can include...
The invention relates to a mutant .alpha.-hemolysin (.alpha.-HL) pore which is useful for detecting one or more nucleotides by stochastic sensing. The pore is...
Beta sheet tapes ribbons in tissue engineering
There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel...
Peptide domains that bind small molecules of industrial significance
Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel,...
Methods and compositions for the rapid synthesis of radiometal-labeled
The present application is directed to rapid and efficient synthesis of radiometal-labeled probes, pharmaceutical compositions comprising radiometal-labeled...
Melanocortin-1 receptor-specific cyclic peptides
Melanocortin receptor-specific cyclic peptides of the formula ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and...
Peptides and methods of use
The invention provides peptides, including peptides that bind and, optionally, inhibit Protein S, and compositions thereof. The peptides may be used to, e.g.,...
Guanylylcyclase C ligands
Guanylin cyclase C compound of the inventions are disclosed. Conjugated compounds comprising guanylin cyclase C compound of the inventions conjugated to...
Compositions for inhibiting immune complex formation in a subject
Polypeptides and other compounds that can bind specifically to the C.sub.H2-C.sub.H3 cleft of an immunoglobulin molecule, and methods for using such...
MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1
The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class...
Peptide fragments for inducing synthesis of extracellular matrix proteins
Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x...
Phage display using contranslational translocation of fusion polypeptides
The present invention relates to a filamentous phage display method wherein the polypeptides of interest displayed on the phage particle are cotranslationally...
Process for the preparation of sterol derivatives
The present invention relates to a process for the preparation of sterol derivatives comprising the reaction of an .alpha.-epoxy compound with an amine in an...
Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions
containing same, and preparation method
The present invention relates to novel chemical compounds, in particular cholest-4-en-3-one oxime derivatives and to the use thereof as medicaments, especially...
Ship inhibitors and uses thereof
The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following...
Potent LNA oligonucleotides for the inhibition of HIF-1a expression
The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of ...
Substituted gemcitabine aryl amide analogs
In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the...
Semisynthetic derivatives of Nystatin A.sub.1
The invention provides semisynthetic derivatives of Nystatin A.sub.1, water soluble salts and complexes, pharmaceutical compositions and plant protection...
Semi-synthetic mithramycin derivatives with anti-cancer activity
Mithramycin derivatives and their pharmaceutically acceptable salts are disclosed. The mithramycin derivatives can be used in the treatment of Ewing sarcoma or...
Compounds and methods for treating mammalian gastrointestinal microbial
Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound selectively...
Synthetic oligosaccharides for moraxella vaccine
The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis...
Highly active nucleoside derivative for the treatment of HCV
A deuterated nucleoside analog of the formula ##STR00001## and the pharmaceutically acceptable salts thereof are provided by this disclosure. The disclosure...
Lignosulfonate of a certain quality and method of preparation of
lignosulfonate of a certain quality
There is provided a process for improving the quality of lignosulfonate at least partly derived form a spent sulfite cooking liquor in at least two steps,...
Process for the preparation of dicycloplatin
The present invention relates to a process to prepare dicycloplatin under mild reactive conditions and at fast reaction rates. The process is reproducible and...
Suprametallogels and uses thereof
The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or...
Method for preparing trishydroxymethyl phosphine
A method for preparing trishydroxymethyl phosphine from tetrakishydroxymethyl phosphonium salt, the method including at least the steps of continuously feeding...
Synthetic lung surfactant and use thereof
The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives,...
Methods and systems for camptothecin analog synthesis
Methods and systems for making camptothecin analogs and intermediates are provided. Aspects include safer and lower cost methodologies for making camptothecin...
Reusable homogeneous cobalt pyridine diimine catalysts for dehydrogenative
silylation and tandem...
Disclosed herein are cobalt complexes containing terdentate pyridine di-imine ligands and their use as efficient, reusable, and selective dehydrogenative...
Multi-thiol mercaptoalkoxysilane compositions
The present invention provides multi-thiol mercaptoalkoxysilane compositions and methods of making multi-thiol mercaptoalkoxysilane compositions having the...
Process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds; use
of the said compounds obtained via...
The process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds and the process for preparing siloxane compounds containing 2-hydroxyphenyl...
Arginase inhibitors and methods of use thereof
The present invention includes arginase enzyme inhibitors, compositions comprising these arginase inhibitors, and methods of treating or diagnosing conditions...
Triazine based radiopharmaceuticals and radioimaging agents
Compounds according to Formula I and Formula II are potent inhibitors of PSMA. ##STR00001## Pharmaceutical compositions may include a complex of a...
Crystalline forms of zinc trisodium pentetic acid
The invention relates to the production of zinc trisodium pentetic acid (Zn-DTPA) and to new crystalline forms of said salt.
Chemical compound for inhibiting the growth and proliferation of human
liver cancer cells HepG2 and method for...
The compound "2-((4-nitrophenyl)amino)-7,8,9,10-tetrahydro cyclohepta[4,5]thieno[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-11(6H)-one- " and method of...
Preparation method of optically active diamine compound
The problem to be solved is to provide a method for efficiently producing compounds (1) and (1a) that are important intermediate compounds in the production of...
Substituted 2-azabicycles and their use as orexin receptor modulators
The present invention is directed to compounds of Formula I: ##STR00001## wherein X is N or CR.sub.1; Y is N or CR.sub.2; R.sub.1 is H, alkoxy, halo,...
Inhibitors of HIV replication
The present invention relates to novel 2,3,4-substituted 5,6,7,8-tetrahydrobenzothieno[2,3-b]pyridine compounds and pharmaceutically acceptable salts...
Organic dyes, process for producing the same and use thereof
The present invention provides an organic dye, a process for producing the same and the use thereof. The organic dye has the structure of formula (I) or formula...
Thieno- and furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives
This invention relates to novel Thieno- and Furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives of formula I ##STR00001## and their use as TRPC5 modulators,...
Organic electroluminescent materials and devices
Novel heterocyclic materials are disclosed. The materials contain a fused tetracyclic structure that can improve the properties of OLED devices when the novel...
Use of parthenolide derivatives as antileukemic and cytotoxic agents
The present invention provides compounds of the formula (I) ##STR00001## wherein: X.sub.1, X.sub.2 and X.sub.3 are heteroatoms; R.sub.4, R.sub.5, R.sub.6,...
Organic thin film transistor, organic semiconductor thin film, and organic
An organic thin film transistor containing a compound represented by the formula (1) in a semiconductor active layer has a high carrier mobility and a small...
Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables...
Crystalline salts of asenapine
Disclosed is asenapine phosphate of formula (I) and its enantiomer (I) which can be used to prepare asenapine maleate. Further disclosed is a monoclinic...
Deuterated morphine derivatives
The invention relates to new morphine derivatives deuterated at the 7,8-position of the morphine ring, furthermore to a process for the preparation thereof, and...
Broadly absorbing metalloporphyrin-based multichromophoric arrays for
The present disclosure relates to multichromophoric assemblies comprising metalloporphyrin scaffolds. The present disclosure also relates, in part, to methods...
Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase
The invention is substituted 4,5-dihydro- and 4,5,6,7-tetrahydro-pyrazolo[1,5-.alpha.]pyrimidine compounds of formula (I), ##STR00001## and salts thereof,...
Triazine compounds and a process for preparation thereof
The present invention discloses triazine compounds of Formula II and a process to synthesize these compounds. Particularly, the invention provides one pot...