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Patent # Description
US-9,447,104 Method of treatment using substituted pyrazolo[1,5-a]pyrimidine compounds
Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
US-9,447,103 Inauhzin analogues that induce P53, inhibit cell growth, and have antitumor activity
Inauhzin (INZ) was identified as a novel p53 activator, which selectively and efficiently suppressing tumor growth without displaying genotoxicity and with...
US-9,447,102 Protein kinase inhibitors
The present invention relates to a novel family of inhibitors of protein kinase of formula 1 and process for their production and pharmaceutical compositions...
US-9,447,101 Pyrrolo[2,1-f][1,2,4]triazine compound, and preparation method and application thereof
The present invention relates to a pyrrolo[2,1-f][1,2,4]triazine compound, an isomer thereof or a pharmaceutically acceptable salt, ester or hydrate thereof,...
US-9,447,100 Substituted pyrazolo[1,5-A] pyrimidines as calcium receptor modulating agents
There is provided a calcium receptor modulator comprising a compound of the formula (I): ##STR00001## wherein ring A is an optionally substituted 5- to...
US-9,447,099 Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo ...
The present invention provides methods for preparing 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyr- ...
US-9,447,098 Pteridines as FGFR inhibitors
The invention relates to new pteridine derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the...
US-9,447,097 4-amino-imidazoquinoline compounds
This invention relates to novel 4-amino-imidazoquinoline compounds of the formula ##STR00001## wherein R.sup.1 to R.sup.4 are as defined in the description...
US-9,447,096 Polymorph forms
The present invention relates to novel crystal forms of 2-amino-N-[2-(3a-(R)-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazol- ...
US-9,447,095 Pyrimidine derivatives as phosphodiesterase 10 inhibitors (PDE-10)
The present invention relates to novel pyrimidine derivatives of formula (I) ##STR00001## as inhibitors of the enzyme phosphodiesterase 10 (PDE-10),...
US-9,447,094 Pyridone derivatives as acid secretion inhibitors and process for preparation thereof
The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful in...
US-9,447,093 3,5-diarylazaindoles as DYRK1A protein inhibitors for the treatment of cognitive deficiencies associated with...
The present invention discloses compositions of novel DYRK1A protein inhibitors based on a 3,5-diarylazaindole motif and their preparation and use as...
US-9,447,092 Pharmaceutically active compounds
The present invention relates to compounds of formula I: wherein R.sub.1 and R.sub.2 are as defined herein, or a pharmaceutically acceptable salt or solvate...
US-9,447,091 Protein kinase inhibitors
A compound of formula (I), wherein R.sub.3, R.sub.4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed....
US-9,447,090 Imidazopyridine compounds
An excellent drug for treating or preventing cardiovascular diseases, based on cGMP production enhancing action due to soluble guanylate cyclase activating...
US-9,447,089 Compositions and uses thereof
Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid ...
US-9,447,088 Compositions and methods for treatment of cancer
The present invention relates to pyrroloquinolinyl-pyrrolidine-2,5-dione compounds in combination with chemotherapeutic agents. The present invention provides...
US-9,447,087 Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders
Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g.,...
US-9,447,086 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and A are as described herein,...
US-9,447,085 Iminothiadiazine dioxides containing a thioamide, amidine, or amide oxime group as BACE inhibitors,...
In its many embodiments, the present invention provides certain C2-ring-substituted iminothiadiazine compounds, or a tautomers thereof, and pharmaceutically...
US-9,447,084 Antiparisitic and pesticidal isoxazoline compounds
The present invention relates to novel and inventive isoxazoline of formula (I) and salts thereof: ##STR00001## wherein variables D.sup.1, D.sup.2, D.sup.3,...
US-9,447,083 N-acylhydrazone derivatives for selective T cell inhibitor and anti-lymphoid malignancy drug
The present invention relates to novel N-acylhydrazone derivatives, and more particularly to novel N-acylhydrazone derivatives having selective T cell...
US-9,447,082 Optically active fluconazole analogues containing thiophenes as antifungal agents
The invention discloses optically active compounds of Formula (1a) or Formula (1b), ##STR00001## wherein R1 and R2 are independently selected from the group...
US-9,447,081 Substituted pyrimidines as pharmaceuticals and insecticides
The invention discloses a homopiperony lamine compound which has a structural general formula I as follows as shown in the specification: ##STR00001## ...
US-9,447,080 Viral polymerase inhibitors
The present invention relates to viral polymerase inhibitors of formula (I) or salts, N-oxides, solvates, hydrates, racemates, enantiomers or isomers thereof,...
US-9,447,079 PRMT1 inhibitors and uses thereof
Described herein are compounds of Formula (I-a) and (I-b), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the...
US-9,447,078 Substituted heterocyclic compounds for disease treatment
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and...
US-9,447,077 Crystalline pharmaceutical and methods of preparation and use thereof
Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed....
US-9,447,076 Inhibitor of p38 map kinase
A compound has the following formula: ##STR00001## The compound is a p38 MAP kinase inhibitor. The compound and its pharmaceutically acceptable salts can be...
US-9,447,075 Pyridazine derivatives as EAAT2 activators
Pyridazine derivatives that activate the excitatory amino acid transporter 2 (EAAT2), and methods use thereof for treating or preventing diseases, disorders,...
US-9,447,074 Compounds
A compound of formula (I): ##STR00001## or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating...
US-9,447,073 Fungicidal compositions
The instant invention describes tetrazole compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof...
US-9,447,072 Pyridone derivative and pharmaceutical containing same
General formula (I): The present invention pertains to: a pyridone derivate or a salt thereof represented by general formula (I); or a medicine containing the...
US-9,447,071 Crystalline polymorphs of the free base of ...
Disclosed are crystalline free base ansolvate forms of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde (or Compound 1), such as...
US-9,447,070 5-substituted isoindoline compounds
This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of...
US-9,447,069 ROR modulators and their uses
The invention relates to ROR modulators; compositions comprising an effective amount of a ROR modulator; and methods for treating or preventing diseases...
US-9,447,068 Functionalized polymer compositions
The invention relates to functionalized polymers including homopolymers and copolymers and their uses in industrial applications and in agricultural...
US-9,447,067 Method of preparing intermediate of salmeterol
A method of preparing an intermediate of salmeterol (Compound 1, 2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol) includes: reacting compound 2 with...
US-9,447,066 Salts and crystal forms
This invention relates to salts and crystal forms of (S)-6-chloro-7-(1,1-dimethylethyl)-2-trifluoromethyl-2H-1-benzopyran-3-ca- rboxylic acid, Compound A, which...
US-9,447,065 Pharmaceutical composition
The present invention provides a pharmaceutical composition which prevents from decreasing the blood exposure of the third generation coxib-drugs, a process for...
US-9,447,064 Heterocyclic compound preparing
Disclosed is a process for selectively producing (D+1)-member heterocyclic compounds from corresponding unactivated dienes or derivatives thereof in the...
US-9,447,063 Disubstituted adamantyl derivative or pharmaceutically acceptable salt thereof, production method for same, and...
The present invention relates to a novel disubstituted adamantyl derivative or the pharmaceutically acceptable salts thereof, a method for preparing the same,...
US-9,447,062 Manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain...
A manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a...
US-9,447,061 Process for preparing epichlorohydrin from dichlorohydrin
The present invention pertains to a process for preparing a product rich in epichlorohydrin, comprising the steps of: a) reacting a mixture of dichlorohydrin...
US-9,447,060 Small molecule modulators of pRb inactivation
The present invention provides a small molecule treatment of diseases/conditions caused by a virus carrying a viral oncoprotein. In one embodiment, the virus...
US-9,447,059 Intermediate for manufacture of polymerizable compound and process for manufacture thereof
The present invention pertains to a compound represented by a formula (I) and a method for producing thereof (in the formula, A.sup.x is an organic group having...
US-9,447,058 Substituted 1,3-thiazoles as heat shock transcription factor 1 activators
The present invention relates to 1,3-thiazole compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically...
US-9,447,057 Schiff bases of thiazoles: a new class of ureases inhibitors
One embodiment of the invention relates to treating diseases associated with increased urease enzyme activity comprising administering an effective amount of a...
US-9,447,056 Solid forms of epalrestat
The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidinea- cetic acid and a novel betaine...
US-9,447,055 .alpha.-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
The invention provides .alpha.-amino esters of a hydroxypropylthiazolidine carboxamide derivative, ...
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