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Patent # Description
US-9,453,067 Stable pharmaceutical liquid formulations of the fusion protein TNFR:Fc
The present invention relates to stable pharmaceutical liquid formulations of the fusion protein TNFR:Fc comprising different buffer systems and stabilizers. In...
US-9,453,066 FC binding protein and method for manufacturing same
Disclosed are: an Fc binding protein having increased stability with respect to heat, acid, and/or alkalinity compared with the wild type; a method for...
US-9,453,065 Protein binding domains stabilizing functional conformational states of GPCRs and uses thereof
The disclosure relates to the field of GPCR structure biology and signaling. In particular, it relates to protein binding domains directed against or capable of...
US-9,453,064 Glucagon-like-peptide-2 (GLP-2) analogues
GLP-2 analogs are disclosed which comprise one of more substitutions as compared to h[Gly2]GLP-2 and which may have the property of an altered GLP-1 activity,...
US-9,453,063 Hybrid polypeptides with selectable properties
The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and...
US-9,453,062 Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and...
US-9,453,061 Method and compositions for treatment of calcineurin-related diseases
Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt...
US-9,453,060 Protein engineered systems for delivery of molecules
Provided are compositions and methods for efficient delivery of polynucleotides and/or small molecules to or into cells. The compositions comprises a peptide...
US-9,453,059 Immunostimulatory oligonucleotides
The invention relates to immunostimulatory oligonucleotides and methods of using immunostimulatory oligonucleotides to induce an antigen-specific immune...
US-9,453,058 Variants of the major allergen Phl P 1 from timothy grass
The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterized in that a preparation, hitherto not...
US-9,453,057 Plasmid-encoded neurotoxin genes in Clostridium botulinum serotype A subtypes
The present invention provides a novel isolated plasmid, wherein the plasmid is a native plasmid found in unique C. botulinum type A strains and encode either...
US-9,453,056 Nucleic acid construct comprising nucleic acid derived from genome of hepatitis C virus of genotype 3a
A nucleic acid includes, in the following order, a 5' untranslated region comprising a particular nucleotide sequence of the genome of hepatitis C virus...
US-9,453,055 Method of producing japanese encephalitis vaccine stably storable over long time and use of the vaccine
The present inventors improved methods for inactivating Japanese encephalitis virus vaccines, and assessed the safety of vaccines produced by combining multiple...
US-9,453,054 Modular DNA-binding domains and methods of use
The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically...
US-9,453,053 Short peptides for enhancing muscle function
The present invention relates to shortened peptides comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding...
US-9,453,052 Cyclotides as immunosuppressive agents
The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression...
US-9,453,051 Cyclosporin derivatives
The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in...
US-9,453,050 Compositions for treating glioma
Isolated peptides, compositions and methods of use for treating tumors infiltrated with macrophages, such as glioblastomas.
US-9,453,049 Substrate-mimetic Akt inhibitor
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the...
US-9,453,048 IAP antagonists
There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds...
US-9,453,047 Agonists of neurotrophin receptors and their use as medicaments
The invention relates to compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts and prodrugs thereof, wherein R.sub.1, R.sub.2, and...
US-9,453,046 Activated carbon filtration for purification of benzodiazepine ADCs
Disclosed are methods of purifying mixtures comprising benzoidiazepine antibody-drug conjugates.
US-9,453,045 Process for the purification of a growth factor protein
A process of purifying the Growth Factor Protein G-CSF (Granulocyte Colony Stimulating Factor) in a purification sequence employing chromatography, comprising...
US-9,453,044 Method of synthesizing peptides, proteins and bioconjugates
The invention relates to the synthesis of peptides, proteins and related bioconjugates, and in particular, to such synthesis using a peptide ligation method...
US-9,453,043 Nucleic acid chemical modifications
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): ##STR00001## Another aspect...
US-9,453,042 Process for the preparation of macrolide antibacterial agents
Described herein are processes for the preparation of compounds of formula (I): ##STR00001## and pharmaceutically acceptable salts, solvates, and hydrates...
US-9,453,041 Method for preparing albiflorin and paeoniflorin
The present invention discloses a method for preparing high purity paeoniflorin and albiflorin simultaneously comprising: extraction the raw material Paeonia...
US-9,453,040 Glycodendrimers of polypropyletherimine
A glycodendrimer comprising: a) a non-toxic dendrimer polypropyletherimine core supporting on average in the range of 9 to 64 terminal carboxylic acid groups,...
US-9,453,039 Crystal structures of SGLT2 inhibitors and processes for preparing same
The present invention relates to physical crystal structures of a compound of the formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.2a, R.sup.3 and...
US-9,453,038 Glucokinase activator compounds, compositions containing such compounds, and methods of treatment
Novel pyridine-2-carboxamide derivatives of formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2...
US-9,453,037 Methylphenidate-prodrugs, processes of making and using the same
The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or...
US-9,453,036 Group 11 mono-metallic precursor compounds and use thereof in metal deposition
The present application provides precursor compounds useful for deposition of a group 11 metal on a substrate, for example, a microelectronic device substrate,...
US-9,453,035 Halogen free syntheses of aminosilanes by catalytic dehydrogenative coupling
Compounds and method of preparation of Si--X and Ge--X compounds (X=N, P, As and Sb) via dehydrogenative coupling between the corresponding unsubstituted...
US-9,453,034 C2-azaspiro iminothiazine dioxides as BACE inhibitors, compositions, and their use
In its many embodiments, the present invention provides certain C2-azaspirosubstituted iminothiazine dioxide compounds. The novel compounds of the invention are...
US-9,453,032 Broad spectrum beta-lactamase inhibitors
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
US-9,453,031 Chemical entities
Provided are chemical entities selected from compounds of formula (I), wherein R.sub.1, R.sub.2 and m have meanings given in the description, and...
US-9,453,030 Oxidative degradation products of atrovastatin calcium
The present invention relates to oxidative degradation products of atorvastatin calcium and the process of the preparation thereof. The present invention also...
US-9,453,029 Macrocycles as factor XIa inhibitors
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all...
US-9,453,028 Protein kinase C inhibitors and uses thereof
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders...
US-9,453,027 Deuterium-enriched pyridinonecarboxamides and derivatives
The present invention relates to deuterium-enriched pyridinonecarboxamides and their derivatives of the formula 1, and pharmaceutically acceptable salts...
US-9,453,026 ACC inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
US-9,453,025 Tricyclic compounds and PBK inhibitors containing the same
Tricyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
US-9,453,024 Polymorphs of darunavir
The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising...
US-9,453,023 Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use...
The present disclosure relates to a series of substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides of formula (Ia) and formula (Ib). ...
US-9,453,022 Use of small molecule inhibitors targeting the interaction between Rac GTPase and p67 (phox)
Inhibitors of p67.sup.phox protein are provided herein, as well as pharmaceutical compositions and methods recited thereto.
US-9,453,021 Pyrimidodiazepinone compound
Provided are a compound represented by general formula (I), or the pharmaceutically acceptable salt thereof, ##STR00001## (wherein R.sup.a represents a...
US-9,453,020 Substituted pentylenetetrazoles as GABA receptor activity modulators
Provided are compounds having formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, and R.sup.10...
US-9,453,019 Linked purine pterin HPPK inhibitors useful as antibacterial agents
The disclosure provides linked purine pterin compounds and analogs thereof that are novel HPPK inhibitors. The HPPK inhibitors described herein are compounds...
US-9,453,018 Pyrimidinones as factor XIa inhibitors
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all...
US-9,453,017 Antiviral therapies with phospholipase D inhibitors
Disclosed are methods of treating viral infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is...
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