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Stable pharmaceutical liquid formulations of the fusion protein TNFR:Fc
The present invention relates to stable pharmaceutical liquid formulations of the fusion protein TNFR:Fc comprising different buffer systems and stabilizers. In...
FC binding protein and method for manufacturing same
Disclosed are: an Fc binding protein having increased stability with respect to heat, acid, and/or alkalinity compared with the wild type; a method for...
Protein binding domains stabilizing functional conformational states of
GPCRs and uses thereof
The disclosure relates to the field of GPCR structure biology and signaling. In particular, it relates to protein binding domains directed against or capable of...
Glucagon-like-peptide-2 (GLP-2) analogues
GLP-2 analogs are disclosed which comprise one of more substitutions as compared to h[Gly2]GLP-2 and which may have the property of an altered GLP-1 activity,...
Hybrid polypeptides with selectable properties
The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and...
Glucose dependent insulinotropic polypeptide analogs, pharmaceutical
compositions and use thereof
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and...
Method and compositions for treatment of calcineurin-related diseases
Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt...
Protein engineered systems for delivery of molecules
Provided are compositions and methods for efficient delivery of polynucleotides and/or small molecules to or into cells. The compositions comprises a peptide...
The invention relates to immunostimulatory oligonucleotides and methods of using immunostimulatory oligonucleotides to induce an antigen-specific immune...
Variants of the major allergen Phl P 1 from timothy grass
The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterized in that a preparation, hitherto not...
Plasmid-encoded neurotoxin genes in Clostridium botulinum serotype A
The present invention provides a novel isolated plasmid, wherein the plasmid is a native plasmid found in unique C. botulinum type A strains and encode either...
Nucleic acid construct comprising nucleic acid derived from genome of
hepatitis C virus of genotype 3a
A nucleic acid includes, in the following order, a 5' untranslated region comprising a particular nucleotide sequence of the genome of hepatitis C virus...
Method of producing japanese encephalitis vaccine stably storable over
long time and use of the vaccine
The present inventors improved methods for inactivating Japanese encephalitis virus vaccines, and assessed the safety of vaccines produced by combining multiple...
Modular DNA-binding domains and methods of use
The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically...
Short peptides for enhancing muscle function
The present invention relates to shortened peptides comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding...
Cyclotides as immunosuppressive agents
The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression...
The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in...
Compositions for treating glioma
Isolated peptides, compositions and methods of use for treating tumors infiltrated with macrophages, such as glioblastomas.
Substrate-mimetic Akt inhibitor
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the...
There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds...
Agonists of neurotrophin receptors and their use as medicaments
The invention relates to compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts and prodrugs thereof, wherein R.sub.1, R.sub.2, and...
Activated carbon filtration for purification of benzodiazepine ADCs
Disclosed are methods of purifying mixtures comprising benzoidiazepine antibody-drug conjugates.
Process for the purification of a growth factor protein
A process of purifying the Growth Factor Protein G-CSF (Granulocyte Colony Stimulating Factor) in a purification sequence employing chromatography, comprising...
Method of synthesizing peptides, proteins and bioconjugates
The invention relates to the synthesis of peptides, proteins and related bioconjugates, and in particular, to such synthesis using a peptide ligation method...
Nucleic acid chemical modifications
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): ##STR00001## Another aspect...
Process for the preparation of macrolide antibacterial agents
Described herein are processes for the preparation of compounds of formula (I): ##STR00001## and pharmaceutically acceptable salts, solvates, and hydrates...
Method for preparing albiflorin and paeoniflorin
The present invention discloses a method for preparing high purity paeoniflorin and albiflorin simultaneously comprising: extraction the raw material Paeonia...
Glycodendrimers of polypropyletherimine
A glycodendrimer comprising: a) a non-toxic dendrimer polypropyletherimine core supporting on average in the range of 9 to 64 terminal carboxylic acid groups,...
Crystal structures of SGLT2 inhibitors and processes for preparing same
The present invention relates to physical crystal structures of a compound of the formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.2a, R.sup.3 and...
Glucokinase activator compounds, compositions containing such compounds,
and methods of treatment
Novel pyridine-2-carboxamide derivatives of formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2...
Methylphenidate-prodrugs, processes of making and using the same
The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or...
Group 11 mono-metallic precursor compounds and use thereof in metal
The present application provides precursor compounds useful for deposition of a group 11 metal on a substrate, for example, a microelectronic device substrate,...
Halogen free syntheses of aminosilanes by catalytic dehydrogenative
Compounds and method of preparation of Si--X and Ge--X compounds (X=N, P, As and Sb) via dehydrogenative coupling between the corresponding unsubstituted...
C2-azaspiro iminothiazine dioxides as BACE inhibitors, compositions, and
In its many embodiments, the present invention provides certain C2-azaspirosubstituted iminothiazine dioxide compounds. The novel compounds of the invention are...
Broad spectrum beta-lactamase inhibitors
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
Provided are chemical entities selected from compounds of formula (I), wherein R.sub.1, R.sub.2 and m have meanings given in the description, and...
Oxidative degradation products of atrovastatin calcium
The present invention relates to oxidative degradation products of atorvastatin calcium and the process of the preparation thereof. The present invention also...
Macrocycles as factor XIa inhibitors
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all...
Protein kinase C inhibitors and uses thereof
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders...
Deuterium-enriched pyridinonecarboxamides and derivatives
The present invention relates to deuterium-enriched pyridinonecarboxamides and their derivatives of the formula 1, and pharmaceutically acceptable salts...
ACC inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
Tricyclic compounds and PBK inhibitors containing the same
Tricyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
Polymorphs of darunavir
The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising...
Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and
amides, preparation and therapeutic use...
The present disclosure relates to a series of substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides of formula (Ia) and formula (Ib). ...
Use of small molecule inhibitors targeting the interaction between Rac
GTPase and p67 (phox)
Inhibitors of p67.sup.phox protein are provided herein, as well as pharmaceutical compositions and methods recited thereto.
Provided are a compound represented by general formula (I), or the pharmaceutically acceptable salt thereof, ##STR00001## (wherein R.sup.a represents a...
Substituted pentylenetetrazoles as GABA receptor activity modulators
Provided are compounds having formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, and R.sup.10...
Linked purine pterin HPPK inhibitors useful as antibacterial agents
The disclosure provides linked purine pterin compounds and analogs thereof that are novel HPPK inhibitors. The HPPK inhibitors described herein are compounds...
Pyrimidinones as factor XIa inhibitors
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all...
Antiviral therapies with phospholipase D inhibitors
Disclosed are methods of treating viral infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is...