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Patent # Description
US-9,453,016 Terpenoid spiro ketal compounds with LXR agonists activity, their use and formulations with them
The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids...
US-9,453,015 Pyrazole derivative
It has been desired to develop a pharmaceutical composition, which is used in agents for preventing and/or treating various diseases related to PDE10 (e.g....
US-9,453,014 Cyclic amide derivatives as inhibitors of 11-.beta.-hydroxysteroid dehydrogenase and uses thereof
The present invention relates amide compounds of formula (I): ##STR00001## wherein R.sup.1, R.sup.1a, Ar, A, B, W.sup.1, W.sup.2, D, a, b, and c are defined...
US-9,453,013 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
Compounds of formula (I) defined herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention...
US-9,453,012 Aminomethylene pyrazolones with therapeutic activity
A compound having the structure according to formula III wherein: X is NH or S; R.sup.1 is H or (1C-4C)alkyl; R.sup.2 is (1C-4C)alkyl, phenyl or a monocyclic...
US-9,453,011 Crystal form of dabrafenib mesylate and preparation method thereof
The present invention involves novel crystal forms of Dabrafenib mesylate and preparation method thereof, wherein the novel crystal forms are more stable in...
US-9,453,010 Marker dyes for UV and short wave excitation with high stokes shift based on benzoxazoles
The invention concerns compounds based on benzoxazoles wherein selected substituents are each a reactive group A bound via a linker L and adapted to covalently...
US-9,453,009 Synthesis of deuterated morpholine derivatives
The present invention is directed to a process for preparing a 2,26,6-d.sub.4-morpholine derivative represented by Structural Formula (I): ##STR00001## or a...
US-9,453,008 Antithrombotic and antiatherosclerotic agent and method for producing same (variants)
The invention relates to the field of chemical and pharmaceutical industry and medicine and concerns compounds which can be used to produce agents for the...
US-9,453,007 Hepatitis C inhibitors and uses thereof
This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and...
US-9,453,006 Crystalline form having specific crystal habit and pharmaceutical composition containing this crystalline form...
Means for improving the solubility of luliconazole is provided. A crystal of luliconazole represented by the following formula is provided, wherein the crystal...
US-9,453,005 Inhibition of influenza M2 proton channel
Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are...
US-9,453,004 Formylated xanthocillin analogues as neuroprotective agents
Formylated xanthocillin analogs can be used in the treatment of neurodegenerative diseases. The analogs can be prepared synthetically, and at least some of the...
US-9,453,003 Pyrimidine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically...
US-9,453,002 Substituted imidazoles as N-type calcium channel blockers
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are...
US-9,453,001 Avanafil preparation method
Disclosed is a method for preparing avanafil (I) by using cytosine as the starting material. The preparation steps comprise: using cytosine as the raw material,...
US-9,453,000 Polycyclic compound
Disclosed is a compound represented by the formula (I): ##STR00001## or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or...
US-9,452,999 Glucagon receptor modulators
The present invention provides a compound of Formula (I) ##STR00001## or a pharmaceutically acceptable salt thereof wherein R.sup.1, R.sup.2, R.sup.3, A.sup.1,...
US-9,452,998 Protein kinase C inhibitors and methods of their use
PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved...
US-9,452,997 Piperidine and piperazine derivatives as autotaxin inhibitors
The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such...
US-9,452,996 Inhibitors of c-fms kinase
The invention is directed to compounds of Formula I: ##STR00001## wherein Z, X, J, R.sup.2 and W are set forth in the specification, as well as solvates,...
US-9,452,995 Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically...
US-9,452,994 Manufacturing process for pyrimidine derivatives
The invention relates to processes for manufacturing a compound of formula 5, ##STR00001## or a stereoisomer, tautomer or a salt thereof, wherein the...
US-9,452,993 Process for improved seaweed biomass conversion for fuel intermediates, agricultural nutrients and fresh water
The invention relates to an integrated process for the production of 5-hydroxymethyl furfural (HMF), K.sub.2SO.sub.4, levulinic acid and formic acid from...
US-9,452,992 Small molecule inhibitors of ebola and lassa fever viruses
The present invention relates to compositions and methods for the treatment of infection by enveloped viruses, such as Ebola and Lassa fever viruses.
US-9,452,991 Piperidine derivatives as human papilloma virus inhibitors
HPV inhibitors with formula (I) where G.sub.1 represents a hydrocarbonated bond or chain possibly substituted by one or two alkyl groups, G.sub.2 represents a...
US-9,452,990 Complement pathway modulators and uses thereof
The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the...
US-9,452,989 Compounds, sensors, methods, and systems for detecting gamma radiation
Methods, compositions, and systems for detecting gamma radiation is disclosed and described. A compound for detecting gamma radiation can comprise a conjugated...
US-9,452,988 Bendamustine derivatives and methods of using same
The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.
US-9,452,987 Five-membered cyclic anion use thereof as an electrolyte
A pentacyclic anion salt is provided for use thereof in electrolyte compositions. The compound has an inorganic, organic or organometallic cation M of valency m...
US-9,452,986 6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use
Compounds of formula (I) ##STR00001## and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R.sup.1, R.sup.2, and...
US-9,452,985 Tau imaging probe
An object of the present invention is to provide a probe for imaging a .beta.-sheet structure protein which can be used for the diagnosis of conformational...
US-9,452,984 Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted) picolinates
4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine...
US-9,452,983 Method for refining quinolinic acid
Provided is a method for refining quinolinic acid, including the steps of: preparing a fermentation solution including at least one of quinolinic acid and a...
US-9,452,982 Pyridinyl cyclohexanecarboxamide cooling compounds
A method of providing a cooling effect to a product includes the incorporation into the product of at least one compound of the formula I ##STR00001## in which...
US-9,452,981 Pyroglutamic acid esters with improved biodegradability
A pyroglutamic acid ester of formula (1) in which A represents a C.sub.2 to C.sub.4 alkylene group; x represents a number from 1 to 100; R' represents an...
US-9,452,980 Substituted benzamides
The invention relates to compounds of formula ##STR00001## wherein R, R.sup.1, R.sup.2, X, and Y are as defined herein and to a pharmaceutically suitable acid...
US-9,452,979 Method for synthesizing organic matter and submerged plasma device
An organic substance synthesis method according to an embodiment of the present invention is carried out using a submerged plasma device (1000), for example,...
US-9,452,978 Chain transfer agent and emulsion polymerization using the same
To provide a novel compound having both a surface-activating ability and a polymerization controlling ability. A compound represented by the following general...
US-9,452,977 Cyclopentylacrylamide derivative
A compound having a hypoglycemic effect is provided. The compound and a pharmaceutically acceptable salt thereof are useful for the treatment or prevention of...
US-9,452,976 Pactamycin analogs and methods of making thereof
This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster from Streptomyces pactum ATCC 27456, characterization of individual...
US-9,452,975 Biobased carbodiimides, a process for preparation thereof and use thereof
The present invention relates to novel biobased carbodiimides, a process for production thereof and use thereof. The biobased carbodiimides according to the...
US-9,452,974 Stereoselective synthesis of metyrosine
Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure...
US-9,452,973 Modulators of the relaxin receptor 1
Disclosed are modulators of the human relaxin receptor 1, for example, of formula (I), wherein A, R.sup.1, and R.sup.2 are as defined herein, that are useful in...
US-9,452,972 Methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof
Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl...
US-9,452,971 Manufacturing process for memantine
A method for manufacturing 3,5-dimethyl-1-adamantanamine of the present invention comprises: (i) a step of reacting 3,5-dimethyl-1-adamantanol with an acid and...
US-9,452,970 Method for hydrogenating nitroaromatic systems with selected platinum catalysts
A method is described for the catalytic hydrogenation of aromatic nitro compounds with hydrogen to the corresponding amines in the presence of a supported...
US-9,452,969 Polyorganosiloxane compound, method for preparing the same, and copolycarbonate resin comprising the same
A polyorganosiloxane compound, a method of preparing the same, and a copolycarbonate resin comprising the same are disclosed. Particularly, a copolycarbonate...
US-9,452,968 Separation of adipic acid and dodecanedioic acid from corresponding monoacid and hydroxy acid
Disclosed is a process for the separation and purification of a diacid from a fermentation broth withdrawn directly from a fermentation zone for producing the...
US-9,452,967 Process for production of acrylic acid or its derivatives
Processes for the catalytic dehydration of hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid...
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