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Methods and compositions for eliciting an immune response against
hepatitis B virus
The present invention relates to immunization of hypo-responsive groups of individuals. In particular, the present invention provides methods and compositions...
Influenza virus vaccines and uses thereof
The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1...
Influenza virus-like particles (VLPS) comprising hemagglutinin produced
within a plant
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza...
The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic...
GNA1870-based vesicle vaccines for broad spectrum protection against
diseases caused by Neisseria meningitidis
The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly...
Capsular polysaccharide solubilisation and combination vaccines
Precipitated bacterial capsular polysaccharides can be efficiently re-solubilised using alcohols as solvents. The invention provides a process for purifying a...
Isolation of lymphocytes and delivery to splenectomy patients
The present invention includes a method and device for the isolation of lymphocytes, particularly splenic lymphocytes, for administration to patients. In...
Recombinant Lactococcus lactis expressing Escherichia coli colonization
factor antigen I (CFA/I) fimbriae and...
The present disclosure relates generally to therapeutic compositions comprising recombinant bacteria. Further, the disclosure elaborates upon methods of...
Chimeric peptides comprising HER-2 B-cell epitopes and Tcell helper
Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the...
Use of C1-inhibitor for the treatment of secondary edema of the central
The subject of the present invention is, in the most general aspect, the prevention and/or treatment of a secondary edema. In particular, the present invention...
Activators of CXCR3 for the treatment of angiopathies of the eye
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or...
Platelet activation and growth factor release using electric pulses
Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses...
Lectin conjugates for mucin hydration
The invention provides, inter alia, conjugates of a hydratable polymer (such as PEG, polyethylene glycol) and a lectin (such as wheat germ agglutinin, WGA),...
Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of...
Pharmaceutical composition for treating medical conditions and a method
for treating alimentary disorders and...
The present invention refers to a pharmaceutical composition that includes an active ingredient, such as a peptide, which acts as an antagonist and/or inverse...
Use of CHEC peptides to treat neurological and cardiovascular diseases and
The present invention describes compositions and methods for treating and preventing non-degenerative neurological diseases and disorders associated with...
Methods for treating HCV
The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12...
Use of panduratin derivatives or an extract of Boesenbergia pandurata for
enhancing muscle mass growth,...
The present invention relates to the novel use of panduratin derivatives or an extract of Boesenbergia pandurata for enhancing muscle mass growth, fighting...
Composition for preventing or improving metabolic syndrome comprising tea
plant leaf, flower and seed extract
Disclosed is a composition for preventing or improving metabolic syndrome, including a tea plant leaf extract, a tea plant flower extract and a tea plant seed...
Herbal compositions for the prevention or treatment of urinary
incontinence and overactive bladder
Provided in one embodiment is an herbal compositions for the prevention or treatment of urogenital system disorders including urinary incontinence, overactive...
Neuroprotective natural extract from passion fruit
Methods for the treatment and prevention of neural cell and neuro-pathological disorders are provided, comprising contacting the neural cells, or administering...
Probiotic therapies for autism
Provided is a method and a composition for improving behavioral performance in an individual comprising identifying an individual in need of treatment, and...
Use of live bacteria for growth promotion in animals
The present invention relates to the use of F4.sup.+ non-pathogenic Escherichia coli strains to promote growth in an animal. The present invention also relates...
In vivo and ex vivo expansion of hematopoietic stem cells with a targeted
combination of clinically tested, FDA...
The present invention provides a therapeutic approach to maintain and expand HSCs in vivo using currently available medications that target GSK-3 and mTOR. The...
Enhanced stem cell composition
The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and...
Mesenchymal stem cells and supports for tissue regeneration, repair and
Materials and methods for preparing mesenchymal stem cells are described such that the mesenchymal stem cells remain for a longer period of time than would...
Human facilitating cells
The present disclosure relates to human facilitating cells (hFC), and methods of isolating, characterizing, and using such hFCs.
Compositions and methods for treatment of hemorrhage
Methods of treating hemorrhage are provided, comprising diagnosing one or more hemorrhaging or potentially hemorrhaging vessels in a patient and administering...
Collateral gene inactivation biomarkers and targets for cancer therapy
Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a...
Composition for the management of nausea and vomiting
A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a...
NSAIDs-induced gastrointestinal mucosal disorder alleviator and
manufacturing method thereof
A method of manufacturing a medical drug of alleviating damage of gastrointestinal mucosal induced by a non-steroidal anti-inflammatory drug, NSAID, the medical...
Disclosed herein are vesicular formulations that include one or more phospholipids and one or more surfactants and in certain embodiments the use of such...
Acne formulations, treatments, and pressure sensitive patches for delivery
of acne formulations
There are disclosed formulations, medicated skin treatments, methods of treating acne, pressure-sensitive patches with acne formulations, and skin treatments....
Vitamin D compounds and methods for reducing ocular hypertension (OHT)
The present invention relates to compounds and methods for reducing intraocular pressure and treating ocular hypertension in a subject.
Solid ganaxolone compositions and methods for the making and use thereof
In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter...
Pregnancy hormone combination for treatment of autoimmune diseases
The present invention relates to pregnancy hormone combinations and methods of treatment for autoimmune diseases having at least two hormonal components, a...
Oral transmucosal pharmaceutical compositions including testosterone and a
Formulations for oral transmucosal compositions including a synergistic combination of low doses of testosterone with a clomiphene-like selective estrogen...
Topical compositions and methods for making and using same
The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof.
(Bacterio)chlorophyll photosensitizers for treatment of eye diseases and
An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and...
Methods of treating disorders associated with protein aggregation
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an...
Compounds and methods for inducing chondrogenesis
Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes.
Substituted diketopiperazines and their use as oxytocin antagonists
Compounds of formula (1) ##STR00001## wherein R.sub.1 is 2-indanyl, R.sub.2 is 1-methylpropyl, R.sub.3 is 2-methyl-1,3-oxazol-4-yl and R.sub.4 and R.sub.5...
Pyrrole antifungal agents
The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n...
Heterocyclic compounds and methods of use thereof
Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFR.beta. kinase mediated diseases. Also provided are pharmaceutical...
Modulators of toll-like receptors
Provided are modulators of TLRs of Formula II: ##STR00001## pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic...
Small molecule TRAIL gene induction by normal and tumor cells as an
Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating...
Imidazopyridine derivatives, process for preparation thereof and
therapeutic use thereof
The invention relates to compounds corresponding to formula (I): ##STR00001## in which R.sub.2 and R.sub.3 together form, with the carbon atoms of the...
Abuse resistant pharmaceutical compositions
The present invention relates to a composition comprising pharmaceutical active ingredients which are susceptible to, or have potential for, abuse. The...
Methods for treating pancreatic cancer using combination therapies
comprising liposomal irinotecan
Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional...
Biphenyl compounds useful as muscarinic receptor antagonists
This invention provides compounds of formula I: ##STR00001## wherein a, b, c, d, m, n, p, s, t, W, Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6,...