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Patent # Description
US-9,458,253 Amino silane-modified polymers
Modified macromolecular compounds obtainable by using specific amino silane polymerization initiator compounds and optionally chain end-modifying compounds are...
US-9,458,252 Starch esters and method of preparation
A lipophilic starch is provided along with methods of making the same. The starch is prepared by modifying the starch with an organic acid anhydride reagent,...
US-9,458,251 Cellulose resin and process for producing the same
A cellulose resin produced by binding a hydrogenated cardanol containing 3-pentadecylcyclohexanol, and cellulose or a derivative thereof through the reaction...
US-9,458,249 Cellulose ether containing cationic group
Provided is a cationic group-containing cellulose ether which, when incorporated in a hair wash, is able to give an excellent smoothness property and its...
US-9,458,248 Cellulose mixed esters
The present invention relates to cellulose mixed esters, processes for preparing these and uses of the cellulose mixed esters, for example in coating...
US-9,458,247 Methods for digestion of cellulosic biomass solids in the presence of a phenolic solvent generated in situ from...
Digestion of cellulosic biomass solids can be enhanced in the presence of a phenolic solvent. Methods for digesting cellulosic biomass solids can comprise...
US-9,458,246 Proteins specific for BAFF and B7RP1
Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such...
US-9,458,245 ANTI-C-MET tandem Fc bispecific antibodies
Provided herein are tandem Fcs and tandem Fc antibodies ("TFcAs"), e.g., tandem Fc bispecific antibodies ("TFcBAs"), which comprise one or at least two binding...
US-9,458,244 Single chain multivalent binding protein compositions and methods
Provided are protein, nucleic acid, and cellular libraries of single chain multivalent binding proteins (e.g., scDVD and scDVDFab molecules) and methods of...
US-9,458,243 Secondary antibody detected epitope and preparation of same
A method of preparing an epitope for a secondary antibody detected protein tag, comprising: constructing a expressing vector, comprising a nucleotide sequence...
US-9,458,242 Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may...
US-9,458,241 Antibody induced cell membrane wounding
Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent...
US-9,458,240 Anti-BAFFR antibody formulations
Anti-BAFFR antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration...
US-9,458,239 Monoclonal antibodies and fragment thereof directed against the human anti-mullerian hormone type II receptor...
The present invention relates to monoclonal antibodies and fragment thereof directed against the human Anti-Mullerian Hormone type II receptor (AMHR-II) and...
US-9,458,238 Nucleic acid molecules encoding antibodies which bind CCR4 and uses thereof
The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of...
US-9,458,237 Method for inducing cell death in acute lymphoblastic leukemic system cells
The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for...
US-9,458,236 Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human...
US-9,458,235 Method for treating a CX3CR1-associated disease with CX3CR1-binding polypeptides
The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates...
US-9,458,234 TLR2 antagonistic antibody and use thereof
The present invention is directed to a cross-reactive antibody, which specifically inhibits or blocks the mammalian Toll-like receptor 2 (TLR2)-mediated immune...
US-9,458,233 Anti-C5a binding moieties with high blocking activity
The present invention relates to binding moieties that specifically bind to a conformational epitope of C5a, in particular human C5a. Preferred binding moieties...
US-9,458,232 SAA domain-specific antibodies and peptide antagonists and use thereof to treat inflammatory diseases
Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and...
US-9,458,231 Modulators and methods of use
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.
US-9,458,230 Secretory IGA compositions, methods of making and methods of use thereof
Described herein is secretory IgA isolated from the intestinal luminal fluid and intestinal mucosal of animals such as pigs and cows. Also included are methods...
US-9,458,229 Immunogenic proteins and compositions
The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS).
US-9,458,228 Gram-positive bacteria specific binding compounds
The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully...
US-9,458,227 Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as...
US-9,458,226 Recombinant antibodies against H1N1 influenza
Antibodies that bind with high affinity to swine H1N1 virus are described. In vivo experiments showed that one such antibody is able to fully protect mice...
US-9,458,225 Method for purifying lactoferrin
The present invention relates to a method for purifying lactoferrin, which is a pharmacologically important milk protein having various physiological...
US-9,458,224 Method for obtaning thin fibril collagen by contacting native collagen with an antibody
A collagen material having a form of thin fibrils generally free of fibril-bundling proteogylcan interactions, and a method for providing the thin fibril...
US-9,458,223 Von willebrand factor variants having improved factor VIII binding affinity
The present invention relates to a polypeptide comprising a modified von Willebrand Factor (VWF) having a higher Factor VIII binding affinity than non-modified...
US-9,458,222 Method of producing recombinant ADAMTS13 in cell culture
Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a...
US-9,458,221 Adenoviral expression vector encoding a CD40L fusion protein
Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit encoding a secretable polypeptide, the...
US-9,458,220 Single-chain insulin agonists exhibiting high activity at the insulin receptor
Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties can...
US-9,458,219 Human insulin analogue and acylated derivative thereof
The present invention provides a human insulin analog, an acylated derivative thereof and a physiologically acceptable salt. The present invention further...
US-9,458,218 Therapeutic agents comprising fusions of insulin and elastic peptides
The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible,...
US-9,458,217 Methods of managing graft versus host disease
This disclosure relates to the use of drugs to prevent graft versus host disease (GVHD) in a subject after, before, or during a hematopoietic stem cell...
US-9,458,216 Nucleic acid encoding chimeric IL-1 receptor type I antagonists
Featured herein are non-naturally occurring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor...
US-9,458,215 Compositions and methods for osteogenic gene therapy
The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure...
US-9,458,214 Dual function fibroblast growth factor 21 proteins
The present invention relates to dual function fusions proteins comprising fibroblast growth factor 21 (FGF21) and Exenatide, Exendin-4, or GLP-1. Also...
US-9,458,213 Compositions and methods for diagnosing prostate cancer based on detection of SLC45A3-ELK4 fusion transcript
RNA transcripts representing a fusion of a human SLC45A3 nucleic acid and a human ELK4 nucleic acid that are associated with prostate cancer are described....
US-9,458,212 Nanoparticles containing a peptide, vectors containing said nanoparticles, and pharmaceutical uses of said...
The present invention relates to nanoparticles containing a P140 peptide and to carriers, with or without dispersant, containing the nanoparticles. The present...
US-9,458,211 Recombinant proteins that simultaneously bind HGF, VEGF-A and serum albumin, comprising ankyrin repeat domains
New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat...
US-9,458,210 Antibody reacting with native Cochlin-tomoprotein (CTP) and method for measuring CTP using same
An immunological measurement is performed using anti-CTP antibody characterized by recognizing an antigenic determinant included in the polypeptide represented...
US-9,458,209 Methods and compositions using Klotho-FGF fusion polypeptides
The present invention is directed to fusion polypeptides comprising a Klotho protein or an active fragment thereof and FGF23 or an active fragment thereof.
US-9,458,208 Optically-based stimulation of target cells and modifications thereto
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for...
US-9,458,207 Methods for refolding G-CSF from inclusion bodies
New methods for the refolding of recombinant granulocyte colony stimulating factor (G-CSF) from inclusion bodies are disclosed. The methods comprise two...
US-9,458,206 L-amino acid-producing bacterium and a method for producing an L-amino acid
A bacterium belonging to the family Enterobacteriaceae, which has an ability to produce an amino acid such as L-cysteine and has been modified to have specific...
US-9,458,205 Modified DNA-binding proteins and uses thereof
Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including...
US-9,458,204 Fusobacterium polypeptides and methods of use
The present invention provides isolated polypeptides isolatable from a Fusobacterium spp. Also provided by the present invention are compositions that include...
US-9,458,203 Integrin-blocking polypeptides and uses thereof
A series of integrin blockers that present strong angiogenesis inhibiting performance, high integrin affinity and integrin-bonding capacity is provided. This...
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