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Process for producing polyurethane resin
A process for producing a polyurethane resin of the present invention includes a step (i) of obtaining a prepolymer by adding an alcohol (B) to isocyanate (A)...
Premix and method for producing a thermally expandable and curable
A two-component premix for preparing a heat-expandable and heat-curable epoxy-based material, comprises an isocyanate, a diol or polyol, an epoxy prepolymer, a...
Foam material on the basis of phenolic resin
Disclosed is a method of preparing a bio-based thermosetting foam material with improved properties, in particular improved flame retardant properties, which...
Lactamic polymer containing an acetoacetate moiety
The invention provides lactamic polymers comprising an acetoacetate moiety. The lactamic polymers may be readily functionalized and the functionalized lactamic...
Molecularly imprinted polymers
The present invention refers to new classes of polymerizable monomers targeting biotin, a biotin derivative, a biotin analog or a biotinylated molecule and...
Heat-shrinkable tube having tearability
The present disclosure relates to a heat-shrinkable tube having tearability, which is made of a fluororesin, and particularly, to a heat-shrinkable tube having...
Vinyl terminated polyethylene with long chain branching
Vinyl terminated polyolefins with long chain branching produced with Salan catalysts having carbazole moieties.
Process for preparing olefin polymer by slurry loop polymerization having
high powder density
The instant invention pertains to a process for preparing an ethylene homo- or copolymer in the presence of a supported chromium catalyst by slurry loop...
Chloroprene rubber, method for producing same, chloroprene rubber
composition and vulcanized product of...
Provided are a chloroprene rubber that is less adhesive to rolls and gives a vulcanized product superior in physical properties, a production method thereof, a...
Metallocenes and catalyst compositions derived therefrom
This invention relates to a novel group 4 transition metal metallocene catalyst compound that is asymmetric having two non-identical indenyl ligands with...
Enhanced procatalyst composition and process
Disclosed herein are processes for preparing procatalyst compositions and polymers, i.e., propylene-based polymers, produced therefrom. The present procatalyst...
The invention provides a method for producing a polymeric photoinitiator of the general formula I: Polymer-[CR2-CHR-Spacer (PI).sub.n].sub.m, (I) wherein m is...
Method for production of cellulose nano crystals from cellulose-containing
A process is disclosed for recovering pure cellulose from a cellulose-containing sludge, the process comprising treating a sludge cellulose source under...
Anti-ETBR antibodies and immunoconjugates
The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody...
Compositions and methods for treatment of cancer
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T...
GITR antigen binding proteins and methods of use thereof
Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic...
Method for the production of domain antibodies
The present invention relates to a method for producing a domain antibody in a yeast, wherein the formation of disulfide bridges in the domain antibody is...
The invention relates to a composition comprising a glycoprotein comprising the Fc domain of an antibody, or a fragment thereof, comprising an Asn (asparagine)...
Antibody-based constructs directed against tyrosine kinase receptors
The present invention features antibody-based constructs that include a combination of two or more of a tetrameric antibody, a single chain antibody, a diabody,...
Epithelial membrane protein-2 (EMP2) and proliferative vitroretinopathy
Methods of preventing retinal detachment associated with proliferative vitreoretinopathy are provided by administering agents which antagonize the activity or...
Polynucleotides encoding antagonists of IL-17A, IL-17F, and IL-23p19
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include...
CDR-modified anti-Siglec-15 antibody
Provided is a pharmaceutical composition for the treatment and/or prophylaxis of abnormal bone metabolism targeting a protein encoded by a gene strongly...
Nanoantibodies, binding Chlamydia trachomatis antigen, method for
inhibition of infection induced by Chlamydia...
A nanoantibody specifically binding surface antigen of Chlamydia trachomatis and having SEQ ID NO:2 amino acid sequence is disclosed. A nanoantibody...
Broadly neutralizing human immunodeficiency virus type 1 (HIV-1)
GP120-specific monoclonal antibody
The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for...
Nucleic acids encoding a cold- and menthol-sensitive receptor
The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member...
Neuronal exocytosis inhibiting peptides
The invention relates to peptides of general formula (I): R.sub.1-AA-R.sub.2 (I) which can regulate neuronal exocytosis, their stereoisomers and racemic or...
Site-specific pegylated linear salmon calcitonin analogues
The present invention relates to site-specific PEGylated linear salmon calcitonin analogs, or pharmaceutically acceptable salts thereof, process for their...
Fusion molecules and IL-15 variants
The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such...
Chimeric fibroblast growth factor 21 proteins and methods of use
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine...
Engineered potent cytotoxic stapled BH3 peptides
Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences...
Engineered nucleic acids and methods of use thereof
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of ...
Peptides having activity of inhibiting infections of respiratory viruses
and use of the same
Peptides having activity of inhibiting infections of respiratory viruses and use of the same are disclosed. The peptides can be synthesized by chemical or...
Methods and compositions comprising tau oligomers
Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed...
Compositions and methods for treating erectile dysfunction
The present invention features compositions and methods for the treatment of erectile dysfunction. The compositions include substantially pure polypeptides...
Compositions for treatment of celiac disease
The invention provides agents and vaccines for treating and diagnosing celiac disease. In particular, the present invention provides a combination of three...
Assembly activating protein (AAP) and its use for the manufacture of
parvovirus particles essentially...
The present invention relates to nucleic acids encoding the novel parvoviral protein "assembly activating protein" (AAP), the encoded polypeptides, methods of...
Polymers containing multivalent amyloid-beta-binding D-peptides and their
The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have...
Herbicide-resistant proteins, encoding genes, and uses thereof
Some embodiments of the present invention can include herbicide-resistant proteins, coding genes, and uses thereof. Certain herbicide-resistant proteins can...
Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
The present invention provides novel n-alkenyl glycosides and glycoconjugates, n-alkyl glycoamino acids, and methods for the synthesis thereof. In another...
Stabilized alpha helical peptides and uses thereof
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to...
Peptides that block leukocyte recruitment and methods of use
Disclosed are novel peptides comprising SEQ ID NO: 1 and modifications thereof, which are effective in blocking leukocyte recruitment. The disclosed peptides...
Anti-heparan sulfate peptides that block herpes simplex virus infection in
Provided are anti-heparan sulfate peptides and methods that employ those peptides for the prevention or treatment of viral infections, including herpesviral...
Peptides having NF-.kappa.B inhibitory activity, or composition comprising
Provided are small peptide fragments derived from the NF-.kappa.B p65 subunit and a pharmaceutical or cosmetic composition comprising the same. The peptides...
Short peptides and a method of use as an antioxidant
A short chain polypeptide having antioxidant activity is provided. The short chain polypeptide has 2 to 4 amino acids bonded to form a polypeptide chain having...
Acyl dipeptide derivative
An acyl dipeptide derivative represented by the formula (1): ##STR00001## wherein an acyl group represented by R.sup.1--CO-- is a saturated or unsaturated,...
Method for the selective enrichment and labeling of phosphorproteins
A method for the introduction of a labeling structure such as fluorescent molecules or a Raman tag to a compound is described. Imidazole functionalized resins...
Combined synthesis route for desogestrel and etonogestrel
The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and...
Labeled nucleotide analogs
Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions that include structural components including double-stranded nucleic...
Oligonucleotides useful for detecting and analyzing nucleic acids of
The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and...
Hydroxylated KRN7000 analogue and use thereof
The invention provides a compound represented by the formula (I) ##STR00001## wherein R.sub.1 is a hydrogen atom or a hydroxyl group; two R.sub.2 are the same...