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Patent # Description
US-9,464,104 Ono pincer ligands and ono pincer ligand comprising metal complexes
Embodiments of the invention are directed to ONO pincer ligands that can be in a trianionic, protonated or protonated equivalent form. The ONO pincer ligand can...
US-9,464,103 Spirocyclic sulfones as gamma secretase inhibitors
Disclosed herein are compounds of Formula (I), wherein each of the substituents is given the definition as set forth in the specification and claims. Also...
US-9,464,102 Prodrugs of pyridone amides useful as modulators of sodium channels
The invention relates to prodrug compounds of formula I: ##STR00001## wherein R.sup.2, R.sup.3, R.sup.5, R.sup.7 and X are as defined herein. The invention...
US-9,464,101 Production of lithium diphenylphosphide
Lithium diphenylphosphide solutions in a solvent, e.g., diethoxymethane (DEM), that are more stable than when tetrahydrofuran (THF) is used as a solvent....
US-9,464,100 Organosilicon compound, adhesive composition and article
An organosilicon compound having a hydrolyzable silyl group and a catechol group in the molecule is novel. When modified by surface treatment with an adhesive...
US-9,464,099 Method for producing hydrosilanes containing carbon
The present invention provides processes for preparing carbon-containing hydridosilanes, in which an optionally boron- or phosphorus-doped hydridosilane is...
US-9,464,098 Substituted triazole boronic acid compounds
The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to...
US-9,464,097 Gold complexes
Gold (I) hydroxide complexes of the form Z--Au--OH and digold complexes of the form Z--Au-(.mu.OH)--Au--Z where groups Z are two electron donors are provided....
US-9,464,096 Therapeutic compounds
The invention provides compounds of formula I: ##STR00001## or a salt thereof as described herein. The invention also provides pharmaceutical compositions...
US-9,464,095 Production method of high-purity nitrogen-containing heterocyclic compound
A method for producing a high-purity nitrogen-containing heterocyclic compound includes: a process (a) and a process (b): (a) a process of mixing a mixture...
US-9,464,094 Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
Stable crystalline forms of a compound represented by the formula (IA): ##STR00001## an acid addition salt, and/or a solvate thereof are provided by the...
US-9,464,093 Substituted imidazo[4',5':4,5]cyclopenta[1,2-e]pyrrolo[1,2-a]pyrazines and ...
This document relates to compounds and compositions useful for treating cancers, such as brain and nervous system cancers. For example, such compounds include a...
US-9,464,092 Transient protection of normal cells during chemotherapy
This invention is in the area of improved compounds, compositions and methods of transiently protecting healthy cells, and in particular hematopoietic stem and...
US-9,464,091 Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo...
US-9,464,090 Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their...
US-9,464,089 Heterocyclic compounds and uses thereof
The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the...
US-9,464,088 Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus...
US-9,464,087 Difluoromethylation of unsaturated compounds
A reagent for carrying out a difluoromethylation reaction of unsaturated compounds and ring-nitrogen-containing aromatic compounds, a zinc ...
US-9,464,086 Crystalline forms of N,N-dicyclopropyl-4-(1,5-dimethyl-1 ...
Crystalline form, Form N-2, of N,Ndicyclopropyl-4-(1,5-dimethyl-1Hpyrazol-3-ylamino)-6-ethyl-1-methyl-1,- ...
US-9,464,085 Inhibitor compounds of phosphodiesterase type 10A
The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof. ...
US-9,464,084 P2X7 modulators
The present invention is directed to compounds of Formulas (I, IIa and IIb): ##STR00001## The invention also relates to pharmaceutical compositions comprising...
US-9,464,083 Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-yl- ...
The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl- ...
US-9,464,082 Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
The present application relates to: (a) compounds of Formula (I): ##STR00001## and salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6,...
US-9,464,081 Pyrrolidine derivatives and their use as complement pathway modulators
The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as a factor D...
US-9,464,080 Substituted pyrido[2,3-d]pyrimidines for dry skin and anti-ageing application
The present invention relates to the cosmetic use, as agent for preventing and/or treating an aesthetic defect in the skin and/or its appendages that is...
US-9,464,079 Treatment of proliferative disorders with a chemiluminescent agent
Methods employing chemiluminescent agents as therapeutically active agents in the treatment of proliferative disorders are disclosed. The chemiluminiscent...
US-9,464,078 Monohydrate of azaadamantane derivatives
The invention relates to a crystalline monohydrate of (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.1.sup.3,7]- decane dihydrogen citrate,...
US-9,464,077 Nitrogen-containing aromatic heterocyclic compound
Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action,...
US-9,464,076 Benzothiophene derivative
Compounds having PDE10A inhibitory activity and having general formula (I), or an isotope thereof or a pharmaceutically acceptable salt thereof, and a...
US-9,464,075 Influenza A virus inhibition
Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are...
US-9,464,074 Method for producing epoxy compound
There is provided a method for producing an epoxy compound having an epoxy ring bonded to a triazinetrione ring via a long chain alkylene group, an olefin...
US-9,464,073 Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
The present invention relates to pyrimidine hydroxy amide compounds, the use of such compounds in the inhibition of HDAC6, and the use of such compounds in the...
US-9,464,072 Treatment of central nervous system disorders
A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and...
US-9,464,071 Pyrazolyl quinoxaline kinase inhibitors
The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of...
US-9,464,070 Sterically hindered amine stabilizer
The present invention relates to oxygen-substituted sterically hindered amines of the formulae I or II: (II), wherein, for example, F.sub.2, R.sub.3, R.sub.5,...
US-9,464,069 1,2-disubstituted cyclobutyl compounds
The invention refers to compounds of general formula (I) ##STR00001## wherein the variables take various meanings, pharmaceutical compositions containing them...
US-9,464,068 Allyl compound and method for producing the same
The allyl compound of the present invention is represented by general formula (.alpha.): ##STR00001## wherein ring Z.sup.1 is a naphthalene ring, ring Z.sup.2...
US-9,464,067 Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for...
Disclosed are indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for...
US-9,464,066 Deuterated compounds useful for treating neurodegenerative diseases
The present application is related to deuterated compounds which are novel neurotrophin mimetics. The application also discloses the treatment of disorders...
US-9,464,065 Compounds and methods for inducing chondrogenesis
The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into...
US-9,464,064 HCV helicase inhibitors and methods of use thereof
The present invention discloses thioflavine S and primuline derivatives which inhibit hepatitis C virus helicase and protease activity. Consequently, the...
US-9,464,063 Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators
Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes...
US-9,464,062 Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2B activity modulators
Pharmaceutical compositions of the invention comprise disubstituted oxazolidin-2-ones derivatives having a disease-modifying action in the treatment of diseases...
US-9,464,061 N-hydroxylamino-barbituric acid derivatives
The present disclosure provides N-hydroxylamino-barbituric acid compounds of formulae (1)-(4), pharmaceutical compositions and kits comprising them, and methods...
US-9,464,060 Compounds
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, ##STR00001## wherein R.sup.1, X, m, R.sup.2, Y,...
US-9,464,059 Benzamide derivatives
Disclosed are benzamide derivatives having the formula ##STR00001## wherein X is selected from the group consisting of H, halo, --C.sub.1-C.sub.6 alkyl, aryl,...
US-9,464,058 Imidazolylketone derivatives
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 n are as described herein,...
US-9,464,057 Anti-malarial agents
The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the...
US-9,464,056 Fungicidal 4-methylanilino pyrazoles
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein R.sup.1 is F, Cl or Br; R.sup.2 is H,...
US-9,464,055 Quinoline derivatives useful as CB-1 inverse agonists
The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders...
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