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Anti-ETBR antibodies and immunoconjugates
The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody...
This application relates to methods for the purification of saccharide antigen-carrier protein conjugates. In particular, the invention provides a method for...
The present disclosure provides crystalline insulin-conjugates. The present disclosure also provides formulations, methods of treatment, methods of...
Material, method for preparing same, and uses thereof
A material including a continuous aqueous phase and a dispersed phase in the form of droplets containing an amphiphilic lipid and a surfactant having the...
Branched alkyl and cycloalkyl terminated biodegradable lipids for the
delivery of active agents
The present invention relates to a cationic lipid of formula (I) having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain)...
Controlled release formulations of levodopa and uses thereof
The current invention provides a controlled release oral solid formulation of levodopa comprising levodopa, a decarboxylase inhibitor, and a carboxylic acid....
Entrapment of bioactives in sol-gel alumina materials
Provided is a platform for entrapment within alumina sol-gel carriers of labile biologically active materials such as proteins, therapeutic enzymes, enzymes of...
Compositions and methods for nucleic acid delivery
The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a...
Amorphous medicinal fine particles produced by pulsed laser ablation in
liquid and the production method thereof
The present disclosure is directed to an in-liquid laser-based method for fabricating a solution of fine particles of amorphous solid medicinal compounds, a...
Methods for treating prostate cancer
Disclosed herein are methods and compositions for reducing the recurrence of prostate cancer and for treating prostate cancer.
Method for stabilising an immunoglobulin G composition in liquid form
This invention is related to a stabilizing formulation for immunoglobulins G compositions comprising a sugar alcohol, glycine and a non-ionic detergent, which...
Arranging interaction and back pressure chambers for microfluidization
An improved method for the manufacture of an oil-in-water emulsion comprises using a microfluidization device whose interaction chamber comprises a plurality of...
Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other
The present invention provides improved treatment methods by the administration of both an inhibitor of indoleamine-2,3-dioxygenase in addition to the...
Recombinant poxvirus vector comprising tetanus toxin fragment C
The present invention relates to a recombinant poxvirus comprising tetanus toxin fragment C for improved immunogenicity of an antigen and related methods and...
Recombinant viral vectors and methods for inducing a heterosubtypic immune
response to influenza A viruses
The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to influenza A...
RSV mucosal vaccine
A composition comprising the following composition: an AD vehicle including a synthetic peptide and a lipid, wherein the synthetic peptide includes the amino...
Dengue virus vaccine composition
Vaccine compositions that comprise at least one antigen based on the dengue virus (DV) capsid protein and the oligonucleotide identified as SEQ ID NO 1. The...
Attenuated african swine fever virus strain induces protection against
challenge with homologous virulent...
African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal viral disease of domestic pigs that has significant economic...
Avirulent, immunogenic flavivirus chimeras
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural...
Vault compositions for immunization
Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an...
Immunogenic compositions comprising Lawsonia intracellularis
The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of...
Compositions produced using enteric pathogens and methods of use
The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or...
Modified protozoan expressing at least two variable surface proteins
(VSP), a vaccine comprising it and...
Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also...
Application of mRNA for use as a therapeutic against tumour diseases
The present invention relates to a pharmaceutical composition comprising at least one mRNA comprising at least one coding region for at least one antigen from a...
This invention provides methods and compositions for using Listeria monocytogenes as an adjuvant for enhancing immune responses in a subject.
Method for treating stage IV melanoma
The present invention relates to a method of treating Stage IV melanoma in a subject. The method includes the step of administering to the subject a...
Therapeutic agent for disc herniation
The present invention provides a therapeutic agent for disc herniation, which has extremely few adverse side effects, can achieve a prolonged pain-ameliorating...
Compositions and methods for enhancing metal ion dependent drug therapies
Methods and compositions are provided for increasing responsiveness to therapeutic metalloproteases including increasing and/or maximizing responsiveness and...
Method for monitoring development of somatic mosaicism
The invention is directed to treatment of systemic DNA mutation diseases accompanied with development of somatic mosaicism and elevation of blood extracellular...
Methods for treatment of complications of prematurity comprising
administration of IGF-I and IGFBP-3
The present invention relates to a composition comprising Insulin Growth Factor I (IGF-I) or an analog thereof in combination with Insulin Growth Factor Binding...
Stabilization of FSH
The present invention pertains in general to the field of stabilization of FSH formulations, in particular liquid FSH formulations. The stabilization is...
Method for inducing twin calving
The present invention provides a method for inducing twin calving. The method according to the present invention comprises firstly treatment to inducing atresia...
Method for treating brain cancer using a novel tumor suppressor gene and
The present invention is directed to methods of using HSS1 (Hematopoietic Signal peptide-containing Secreted 1), HSM1 (Hematopoietic Signal peptide-containing...
Transfer factor for improving fertility
A method of using a fertility enhancement food to improve human fertility. This fertility enhancement food consists of transfer factor, lactic acid generating...
Methods and pharmaceutical compositions for treatment of retinal occlusion
The present invention relates to methods and compositions for the treatment of retinal vein occlusion.
Poly-glutamic acid anti-anthrax compositions and methods for using the
Methods and compositions for inhibiting entry of an anthrax toxin and/or an anthrax toxin protein into a cell are provided. Aspects of the subject methods...
Romidepsin formulations and uses thereof
Provided herein are liquid concentrate formulations of romidepsin. Also provided are methods for producing these formulations and uses thereof. In one...
Antibiotic peptide derived from helicobacter pylori ribosomal protein L1
and uses thereof
The present invention relates to a peptide derived from the Helicobacter pylori ribosomal protein L1, and the use of this peptide an antibiotic. More...
Use of degarelix in the treatment of endometriosis and related diseases
The use of degarelix in the treatment of endometriosis, in particular in the treatment of endometriotic ovarian cysts and recurrent endometriotic lesions...
Antimicrobial and antiviral composition
A method of reducing the number of microorganisms entering the nose and proliferating in the nasal cavity including application of a solution of an...
Skin salve for treating intertrigo
The subject patent discloses a method for treating intertrigo on the underside of a female breasts which comprises (1) applying a skin salve to the underside of...
Method for alleviating cravings and discomfort associated with smoking
A method for alleviating cravings and discomfort of a user due to nicotine addiction upon immediate cessation of tobacco by said user, comprising the steps of...
Bacterial extract for respiratory disorders and process for its
The present invention relates to an extract from bacterial strains, such as Staphylococcus, Moraxella, Klebsiella, Streptococcus, and Haemophilus. The extract...
Bacteriotherapy for clostridium difficile colitis
This document discusses, among other things, receiving a plurality of donor fecal samples from a plurality of donors and storing and indexing each respective...
Placental tissue grafts
A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the...
Cross-linked dehydrated placental tissue grafts and methods for making and
using the same
Described herein are tissue grafts produced by contacting dehydrated placental tissue grafts with a cross-linking agent. The tissue grafts described herein...
Non-invasive in vivo imaging and methods for treating type I diabetes
The present invention provides novel drug discovery platforms and methods for treating type I diabetes.
Method for inducing differentiation enabling tumorigenesis of IPS cells to
The object of the invention is to provide a technique of suppressing tumorigenesis in IPS cells and inducing differentiation into target differentiated cells....
Methods of using regenerative cells in the treatment of cartilage defects
Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating...
Dialysis precursor composition
A dialysis acid precursor assembly including a dialysis acid precursor composition of dry components including anhydrous glucose, a dry acid, a magnesium...