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Patent # Description
US-9,474,805 Derivatisation of granulocyte colony-stimulating factor
The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and...
US-9,474,804 Poly(vinyl ester) polymers for in vivo nucleic acid delivery
The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides...
US-9,474,803 Composition for stabilizing fusion protein in which protein and FC domain are fused
The present invention relates to a composition for stabilizing a fusion protein of a physiologically active protein and an Fc domain, and more particularly to a...
US-9,474,802 Compositions and methods to reduce hangover and reduce blood alcohol levels after alcohol consumption
Compositions and methods for preventing and/or reducing hangover, when consumed before, after or during drinking alcohol. Compositions of the inventions include...
US-9,474,801 Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor...
US-9,474,800 Expression vector encoding alphavirus replicase and the use thereof as immunological adjuvant
The present invention relates to an alphaviral replicase, especially Semliki Forest Virus replicase, or an expression vector encoding an alphaviral replicase,...
US-9,474,799 Functional influenza virus-like particles (VLPS)
Recombinant influenza virus proteins, including influenza capsomers, subviral particles, virus-like particles (VLP), VLP complexes, and/or any portions of...
US-9,474,798 Influenza M2 protein mutant viruses as live influenza attenuated vaccines
A method to prepare recombinant influenza viruses comprising a mutant M2 protein which has a deletion of two or more residues in the cytoplasmic tail and is...
US-9,474,797 African swine fever virus georgia strain adapted to efficiently grow in the vero cell line
We have developed an ASFV Georgia strain adapted to grow in Vero cell line. The resulting virus, ASF-GVAV, efficiently grows in Vero cells although it still is...
US-9,474,796 Crimean-Congo hemorrhagic fever virus vaccine
The genetically modified hemorrhagic fever virus of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and...
US-9,474,795 Polysaccharide-protein conjugate vaccines
Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group...
US-9,474,794 Antibodies that bind to adrenomedullin and to adrenomedullin receptors and the uses thereof as drugs
The invention relates to antibodies that bind to adrenomedullin and to proteins forming adrenomedullin receptors and to the uses thereof as drugs.
US-9,474,793 Vaccines and methods for prevention and treatment of drug-resistant HIV-1 and hepatitis B virus
The present invention provides methods for lowering a viral load of a virus resistant to an antiviral drug by inducing cytotoxic T lymphocytes (CTL) to...
US-9,474,792 Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides
Methods of treating or ameliorating metabolic diseases using a PLA2G12A polypeptide or PLA2G12A mutant polypeptide are provided. In various embodiments the...
US-9,474,791 Sterile autologous, allogenic or xenogenic implant and the method of its production
The subject of the invention is a sterile, dehydrated acellular implant, which during its rehydration by water or bodily fluids displays anisotropic expansion...
US-9,474,790 Stable, protracted GLP-1/glucagon receptor co-agonists for medical use
The invention relates to novel stable and protracted GLP-1/glucagon receptor co-agonists, to the use of said peptides in therapy, to methods of treatment...
US-9,474,789 Methods and compositions for promoting organ growth and development
Methods and compositions are provided for promoting organ development in warm blooded animals, and in particular in certain aspects a premature infant or...
US-9,474,788 Methods for the reactivation of latent HIV using cytosine methylation inhibitors and NF-KB activators
The present disclosure provides methods and compositions for reactivating latent immunodeficiency virus in an immunodeficiency virus-infected cell. The methods...
US-9,474,787 Mesenchymal stem cells for the treatment of CNS diseases
An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a...
US-9,474,786 Treatment of allodynia
The present invention relates to use of Cometin in a method of treatment of allodynia, hyperalgesia, spontaneous pain and/or phantom pain. In a preferred...
US-9,474,785 Chimeric fibroblast growth factor 19 proteins and methods of use
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine...
US-9,474,784 Therapeutic applications of SMAD7
The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions...
US-9,474,783 HIP/PAP protein and derivatives thereof for use in treating cancer
This invention concerns a HIP/PAP protein or derivative thereof, for its use in treating or managing cancer and preferentially solid tumors.
US-9,474,782 Use of decorin for increasing muscle mass
The invention concerns decorin for increasing muscle mass, particularly in the treatment of muscular dystrophies.
US-9,474,781 Method for inhibiting cell death during liver failure by administering a caspase recruitment domain
The invention refers to the use of a polynucleotide encoding "apoptosis repressor with caspase recruitment domain" (ARC) or a functional fragment thereof,...
US-9,474,780 GIP and GLP-1 co-agonist compounds
The present invention relates to dual incretin peptide mimetic compounds that agonize receptors for both human glucose-dependent insulinotropic polypeptide...
US-9,474,779 Therapeutically active compositions and their methods of use
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a...
US-9,474,778 Herbal polypharmaceutical for preventing and treating atherosclerosis
Herbal MDR for the prevention and treatment of atherosclerosis which includes a summary of the genus Gentiana and a summary of the genus Hippocratea, in...
US-9,474,777 Plant extract and the process for treating hepatic fibrosis and liver cancer
An extract of Graptopetalum paraguayense prepared by a method that includes: extracting a Graptopetalum paraguayense (GP) starting material with an alcoholic...
US-9,474,776 Integrative fungal solutions for protecting bees
The present invention is based on a plurality of benefits from the extracts of mycelia of individual fungal species, and mixtures of species, to provide an...
US-9,474,775 Compound, extract isolated from antrodia camphorate, and method using the same
Disclosed is a compound isolated from Antrodia camphorata, represented by formula I: ##STR00001## wherein R1 is a hydrogen atom or an acetyl group; and a...
US-9,474,774 Pyridine alkaloids, preparation process thereof, and the uses of the pyridine alkaloids
The present invention relates to novel pyridine alkaloid compounds of formula (I): ##STR00001## or a pharmaceutically acceptable derivative thereof as...
US-9,474,773 Lactobacillus supplement for alleviating type 1 diabetes
Isolated Lactobacillus strains are useful in preventing or delaying the development of Type 1 Diabetes (T1D). A probiotic composition comprising the...
US-9,474,772 Method for generating non-pluripotent progenitors of surrogate pancreatic cells
Fresh human pancreas tissue can be used as a source of cells whence to identify and select a non-stem cell population that is predisposed to be a source for...
US-9,474,771 Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor...
US-9,474,770 Prophylactic agent and/or therapeutic agent for sepsis
The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for...
US-9,474,769 Methods of treating cancers
A method of treating cancer. The method includes introducing an effective amount of an oxidative catalyzing agent including titanium oxide, zinc oxide,...
US-9,474,768 Lubricant formulations
A composition for lubricant formulations is disclosed. The composition may include hypochlorite, dimethicone, and an emulsifier for improvement of lubricity....
US-9,474,767 Compositions and methods for inhibiting bone growth
Compositions and methods are provided for a matrix that inhibits bone growth in a patient in need thereof. In one embodiment, a method of inhibiting bone growth...
US-9,474,766 Use of a reduced calorie infant formula containing nucleotides and/or carotenoids for reducing adverse health...
The present disclosure is directed to reduced calorie infant formulas, and in particular, reduced calorie infant formulas that have at least one nucleotide...
US-9,474,765 Composition for lipolysis, containing phosphatidylcholine, and preparation method therefor
A composition for inducing lipolysis includes phosphatidylcholine and a preparation method therefor. More particularly, the composition for inducing lipolysis...
US-9,474,764 Infant nutrition for improving fatty acid composition of brain membranes
The present invention relates to infant nutrition, in particular to infant nutrition comprising special lipid globules for improvement of the fatty acid...
US-9,474,763 Compositions and methods for amelioration and prevention of drug-induced toxicity
Pharmaceutical compositions including combinations of protective agents selected from isosilybin B, methylsulfonylmethane (MSM), phosphatidylcholine, cysteine...
US-9,474,762 Triazolopyridine compounds
The invention relates to compounds of formula (I) and salts thereof: ##STR00001## wherein the substituents are as defined in the specification; a compound of...
US-9,474,761 Use of NK-1 receptor antagonists for treating hypomagnesemia, neurogenic inflammation, and cardiac dysfunction...
The present disclosure provides methods for alleviating or preventing the negative physiological side effects associated with the administration of EGFR...
US-9,474,760 Hypotensive lipid and timolol compositions and methods of using same
New compositions for and methods of treating ocular hypertension provide for effective treatment of ocular hypertension often using reduced concentrations of...
US-9,474,759 Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses,...
Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed,...
US-9,474,758 Thienopyrimidinedione derivatives as TRPA1 modulators
The present invention is related to novel thienopyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular,...
US-9,474,757 Methods for treating cancer using TOR kinase inhibitor combination therapy
Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount...
US-9,474,756 Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
The present disclosure relates to stable formulations of receptor tyrosine kinase inhibitors (TKI), e.g., pazopanib; methods of preparation thereof; and use of...
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