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Methods and compositions relating to improved lentiviral vectors and their
The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy,...
Adenoviral vectors for transduction of vascular tissue
The invention relates to the field of gene transfer, and in particular to the use of adenoviral vectors of serotype Ad49 for gene delivery to vascular tissue.
Generating genotypic variations in plant genomes by gamete infection
A method of generating genotypic variation in a genome of a plant is disclosed. The method comprising introducing into a gamete or a gamete producing tissue of...
Gene capable of imparting environmental stress resistance to plants and
method for utilizing the same
According to the present invention, environmental stress resistance is imparted to a plant or the environmental stress resistance of a plant is improved. At...
Method for speeding up plant growth and improving yield by introducing
phosphatases in transgenic plant
Transgenic plants having increased growth rate, increased sugar content, and increase yield are disclosed, and methods for making the same. The transgenic...
Methods for transferring molecular substances into plant cells
Provided are methods for introducing a molecule of interest into a plant cell comprising a cell wall. Methods are provided for genetically or otherwise...
Recombinant vector for producing and secreting peptide or protein of
interest by propionibacteria and...
The present invention relates to a recombinant vector for expressing and secreting, by a Propionibacterium, at least one eukaryotic peptide or protein of...
Modification of RNA, producing an increased transcript stability and
It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be...
Two-adaptor library for high-throughput sequencing on DNA arrays
The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences using adaptors interspersed in...
Methods and compositions for inhibition of immune responses and
The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The...
RNAi inhibition of alpha-ENaC expression
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC...
Antisense modulation of superoxide dismutase 1, soluble expression
Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense...
The invention is based on a finding that silencing PME-1 gene sensitizes cancer cells for apoptosis-inducing activity of certain small molecule chemotherapeutic...
Guanosine-rich oligonucleotide (GRO) compositions, methods and uses for
treating respiratory syncytial virus...
Provided herein is a method of treating Respiratory Syncytial Virus (RSV) infection in a cell. The method involves administering the guanosine-rich ...
DNA virus MicroRNA and methods for inhibiting same
The invention relates to isolated nucleic acid molecules comprising the sequence of a human cytomegalovirus microRNA. In another embodiment, the invention...
RNAi-mediated inhibition of connexin 43 for treatment of IOP-related
RNA interference is provided for inhibition of connexin 43 (Cx43) in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as...
Methods targeting miR-128 for regulating cholesterol/lipid metabolism
Methods for targeting microRNA 128 (miR-128) for regulating cholesterol/lipid metabolism and insulin sensitivity.
iRNA agents with biocleavable tethers
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose that further...
RNA-interference by single-stranded RNA molecules
The present invention relates to sequence and structural features of single-stranded (ss)RNA molecules required to mediate target-specific nucleic acid...
Diagnosis and treatment of friedreich's ataxia
The present invention is directed to oligonucleotides based on peptide nucleic acid oligonucleotide or an equivalent oligonucleotide analogue, such as...
Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site
The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence...
Method for producing novel hipsc by means of siRNA introduction
A novel compound to induce a pluripotent stem cell is provided. A novel anti-malignant-tumor substance is provided. A pluripotent stem cell-inducing agent,...
Plants with useful traits and related methods
The present invention provides methods for obtaining plants that exhibit useful traits by transient suppression of the MSH1 gene of the plants. Methods for...
Polynucleotides and polypeptides in plants
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of...
Ultra-high-speed nucleic acid extracting apparatus and nucleic acid
extracting method using same
A nucleic acid extraction device, which can realize automation, ultra-miniaturization and super-high speed in the nucleic acid extraction reaction, has no...
Factor VII polypeptides that are modified and uses thereof
Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among...
Cellulolytic enzyme compositions and uses thereof
The present invention relates to recombinant filamentous fungal host cells producing cellulolytic enzyme compositions and methods of producing and using the...
Recombinant polymerases with increased phototolerance
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that...
Ketoreductase polypeptides for the production of azetidinone
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme....
Recombinant newcastle disease viruses useful as vaccines or vaccine
The present invention concerns an antigenomic RNA of Newcastle Disease virus (NDV) carrying one or more foreign genes inserted before NP gene, between P and M...
Attenuated viruses useful for vaccines
This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the...
Method for rejuvenating cells
The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In...
Self-renewing endodermal progenitor lines generated from human pluripotent
stem cells and methods of use thereof
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof are disclosed.
Ex vivo development, expansion and in vivo analysis of a novel lineage of
Disclosed herein are new methods of producing a novel line of dendritic cells. The method comprises subjecting a sample of hematopoietic stem/precursor cells to...
Method for proliferation of antigen-specific T cells
The present invention relates to an in vitro method for priming genetically modified T cells suitable for administration to a patient having a tumor. The...
Enhanced expression of human or humanized immunoglobulin in non-human
The present invention describes transgenic animals with human(ized) immunoglobulin loci and transgenes encoding human(ized) Ig.alpha. and/or Ig.beta. sequences....
Method of tissue repair using a piezoelectric scaffold
Provided is an electroactive structure and method for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a...
Ferromagnetic cell and tissue culture microcarriers
A porous, collagen coated, ferromagnetic cell culture microcarrier, which is suitable for in vitro cell and tissue culture and which facilitates 3D ...
Thermoresponsive substrate with microgels, method for its preparation and
culture method for biological cells
The invention relates to a culture substrate having thermoresponsive microgel particles that have a thermoresponsive polymer and modulator particles fixed to...
The culture device (100, 200) for culturing algae includes a culture pond (110) including an opening (112) on an upper side thereof and accommodating an alga...
Instrumented and controlled fermentation system and process with VOC
A fermentation system include a volatile organic compound (VOC) recovery sub-system and an instrumented control devise for detecting anomalous condition with a...
Method for the regeneration of PVPP from a membrane filter retentate after
clarification and stabilization of a...
A method of preparing a yeast fermented beverage is disclosed, comprising: (a) fermenting wort with yeast to produce a fermented liquid; (b) optionally removing...
Method and apparatus for the recovery of PVPP after contact with a yeast
fermented beverage by sedimentation...
A method of preparing a yeast fermented beverage is provided, which method comprises (a) fermenting wort with a biologically active yeast to produce a fermented...
Cleaning agent for semiconductor provided with metal wiring
A cleaning agent for a microelectronic device provided with metal wiring, which has an excellent ability to remove polishing particle residues derived from a...
Wafer cleaning formulation
Methods and systems for cleaning corrosion product of a metallic layer from the surface of a substrate are provided. According to one embodiment, a treatment...
Compositions and methods for cleaning, disinfecting, and sanitizing that
are effluent neutral
Methods are provided which include a method of cleaning, sanitizing, or disinfecting, wherein the method comprises: contacting a soiled substrate with a...
Cleaning solution, cleaning facility and method of cleaning mount
A method of cleaning a mount substrate comprising the step of: preparing a cleaning solution and cleaning the mount substrate by using the cleaning solution....
Non-toxic hand cleaner comprising a ternary solvent mixture
A cleaning composition comprises between about 10% to about 50% of at least one organic solvent comprising vegetable oil. The composition further comprises...
Method for cleaning surfaces
A method for cleaning an outdoor surface includes combining a first composition from a first vessel with a second composition from a second vessel. The first...
Builder granules and process for their preparation
A process for preparing builder granules suitable for use in a granular or tabletted detergent compositions, particularly for machine dishwash, involves forming...