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Patent # Description
US-9,476,062 Methods and compositions relating to improved lentiviral vectors and their applications
The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy,...
US-9,476,061 Adenoviral vectors for transduction of vascular tissue
The invention relates to the field of gene transfer, and in particular to the use of adenoviral vectors of serotype Ad49 for gene delivery to vascular tissue.
US-9,476,060 Generating genotypic variations in plant genomes by gamete infection
A method of generating genotypic variation in a genome of a plant is disclosed. The method comprising introducing into a gamete or a gamete producing tissue of...
US-9,476,059 Gene capable of imparting environmental stress resistance to plants and method for utilizing the same
According to the present invention, environmental stress resistance is imparted to a plant or the environmental stress resistance of a plant is improved. At...
US-9,476,058 Method for speeding up plant growth and improving yield by introducing phosphatases in transgenic plant
Transgenic plants having increased growth rate, increased sugar content, and increase yield are disclosed, and methods for making the same. The transgenic...
US-9,476,057 Methods for transferring molecular substances into plant cells
Provided are methods for introducing a molecule of interest into a plant cell comprising a cell wall. Methods are provided for genetically or otherwise...
US-9,476,056 Recombinant vector for producing and secreting peptide or protein of interest by propionibacteria and...
The present invention relates to a recombinant vector for expressing and secreting, by a Propionibacterium, at least one eukaryotic peptide or protein of...
US-9,476,055 Modification of RNA, producing an increased transcript stability and translation efficiency
It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be...
US-9,476,054 Two-adaptor library for high-throughput sequencing on DNA arrays
The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences using adaptors interspersed in...
US-9,476,053 Methods and compositions for inhibition of immune responses and autoimmunity
The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The...
US-9,476,052 RNAi inhibition of alpha-ENaC expression
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC...
US-9,476,051 Antisense modulation of superoxide dismutase 1, soluble expression
Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense...
US-9,476,050 Combination therapy
The invention is based on a finding that silencing PME-1 gene sensitizes cancer cells for apoptosis-inducing activity of certain small molecule chemotherapeutic...
US-9,476,049 Guanosine-rich oligonucleotide (GRO) compositions, methods and uses for treating respiratory syncytial virus...
Provided herein is a method of treating Respiratory Syncytial Virus (RSV) infection in a cell. The method involves administering the guanosine-rich ...
US-9,476,048 DNA virus MicroRNA and methods for inhibiting same
The invention relates to isolated nucleic acid molecules comprising the sequence of a human cytomegalovirus microRNA. In another embodiment, the invention...
US-9,476,047 RNAi-mediated inhibition of connexin 43 for treatment of IOP-related conditions
RNA interference is provided for inhibition of connexin 43 (Cx43) in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as...
US-9,476,046 Methods targeting miR-128 for regulating cholesterol/lipid metabolism
Methods for targeting microRNA 128 (miR-128) for regulating cholesterol/lipid metabolism and insulin sensitivity.
US-9,476,045 iRNA agents with biocleavable tethers
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose that further...
US-9,476,044 RNA-interference by single-stranded RNA molecules
The present invention relates to sequence and structural features of single-stranded (ss)RNA molecules required to mediate target-specific nucleic acid...
US-9,476,043 Diagnosis and treatment of friedreich's ataxia
The present invention is directed to oligonucleotides based on peptide nucleic acid oligonucleotide or an equivalent oligonucleotide analogue, such as...
US-9,476,042 Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences
The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence...
US-9,476,041 Method for producing novel hipsc by means of siRNA introduction
A novel compound to induce a pluripotent stem cell is provided. A novel anti-malignant-tumor substance is provided. A pluripotent stem cell-inducing agent,...
US-9,476,040 Plants with useful traits and related methods
The present invention provides methods for obtaining plants that exhibit useful traits by transient suppression of the MSH1 gene of the plants. Methods for...
US-9,476,039 Polynucleotides and polypeptides in plants
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of...
US-9,476,038 Ultra-high-speed nucleic acid extracting apparatus and nucleic acid extracting method using same
A nucleic acid extraction device, which can realize automation, ultra-miniaturization and super-high speed in the nucleic acid extraction reaction, has no...
US-9,476,037 Factor VII polypeptides that are modified and uses thereof
Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among...
US-9,476,036 Cellulolytic enzyme compositions and uses thereof
The present invention relates to recombinant filamentous fungal host cells producing cellulolytic enzyme compositions and methods of producing and using the...
US-9,476,035 Recombinant polymerases with increased phototolerance
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that...
US-9,476,034 Ketoreductase polypeptides for the production of azetidinone
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme....
US-9,476,033 Recombinant newcastle disease viruses useful as vaccines or vaccine vectors
The present invention concerns an antigenomic RNA of Newcastle Disease virus (NDV) carrying one or more foreign genes inserted before NP gene, between P and M...
US-9,476,032 Attenuated viruses useful for vaccines
This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the...
US-9,476,031 Method for rejuvenating cells
The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In...
US-9,476,030 Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof are disclosed.
US-9,476,029 Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells
Disclosed herein are new methods of producing a novel line of dendritic cells. The method comprises subjecting a sample of hematopoietic stem/precursor cells to...
US-9,476,028 Method for proliferation of antigen-specific T cells
The present invention relates to an in vitro method for priming genetically modified T cells suitable for administration to a patient having a tumor. The...
US-9,476,027 Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
The present invention describes transgenic animals with human(ized) immunoglobulin loci and transgenes encoding human(ized) Ig.alpha. and/or Ig.beta. sequences....
US-9,476,026 Method of tissue repair using a piezoelectric scaffold
Provided is an electroactive structure and method for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a...
US-9,476,025 Ferromagnetic cell and tissue culture microcarriers
A porous, collagen coated, ferromagnetic cell culture microcarrier, which is suitable for in vitro cell and tissue culture and which facilitates 3D ...
US-9,476,024 Thermoresponsive substrate with microgels, method for its preparation and culture method for biological cells
The invention relates to a culture substrate having thermoresponsive microgel particles that have a thermoresponsive polymer and modulator particles fixed to...
US-9,476,023 Culture device
The culture device (100, 200) for culturing algae includes a culture pond (110) including an opening (112) on an upper side thereof and accommodating an alga...
US-9,476,022 Instrumented and controlled fermentation system and process with VOC recovery
A fermentation system include a volatile organic compound (VOC) recovery sub-system and an instrumented control devise for detecting anomalous condition with a...
US-9,476,021 Method for the regeneration of PVPP from a membrane filter retentate after clarification and stabilization of a...
A method of preparing a yeast fermented beverage is disclosed, comprising: (a) fermenting wort with yeast to produce a fermented liquid; (b) optionally removing...
US-9,476,020 Method and apparatus for the recovery of PVPP after contact with a yeast fermented beverage by sedimentation...
A method of preparing a yeast fermented beverage is provided, which method comprises (a) fermenting wort with a biologically active yeast to produce a fermented...
US-9,476,019 Cleaning agent for semiconductor provided with metal wiring
A cleaning agent for a microelectronic device provided with metal wiring, which has an excellent ability to remove polishing particle residues derived from a...
US-9,476,018 Wafer cleaning formulation
Methods and systems for cleaning corrosion product of a metallic layer from the surface of a substrate are provided. According to one embodiment, a treatment...
US-9,476,017 Compositions and methods for cleaning, disinfecting, and sanitizing that are effluent neutral
Methods are provided which include a method of cleaning, sanitizing, or disinfecting, wherein the method comprises: contacting a soiled substrate with a...
US-9,476,016 Cleaning solution, cleaning facility and method of cleaning mount substrate
A method of cleaning a mount substrate comprising the step of: preparing a cleaning solution and cleaning the mount substrate by using the cleaning solution....
US-9,476,015 Non-toxic hand cleaner comprising a ternary solvent mixture
A cleaning composition comprises between about 10% to about 50% of at least one organic solvent comprising vegetable oil. The composition further comprises...
US-9,476,014 Method for cleaning surfaces
A method for cleaning an outdoor surface includes combining a first composition from a first vessel with a second composition from a second vessel. The first...
US-9,476,013 Builder granules and process for their preparation
A process for preparing builder granules suitable for use in a granular or tabletted detergent compositions, particularly for machine dishwash, involves forming...
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