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Neutralizing GP41 antibodies and their use
Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are...
Binding molecule having influenza A virus-neutralizing activity produced
from human B cell
The present invention relates to a binding molecule having influenza A virus-neutralizing activity derived from a human B cell, and the binding molecule having...
Process for obtaining immunoglobulins from colostral milk
Suggested is a process for obtaining immunoglobulins, wherein (a) colostral milk from days 0 to 7 is subjected to thermal treatment, skimming the cream, (b) the...
Polynucleotides encoding rodent antibodies with human idiotypes and
animals comprising same
The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes...
Cell culture process
A method for producing recombinant polypeptides, including antibodies, having targeted levels of carboxyl terminal (C-terminal) lysine or arginine residues is...
Methods and compositions using a Klotho-FGF23 fusion polypeptide
The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion...
Chimeric FGF21 proteins with enhanced binding affinity for .beta.-klotho
for the treatment of type II diabetes,...
The present invention relates to chimeric proteins that include an N-terminus coupled to a C-terminus, where the N-terminus includes an N-terminal portion of...
Human Notch3 based fusion proteins as decoy inhibitors of Notch3 signaling
This invention provides a fusion protein comprising a signal peptide, EGF repeats 1-X of the extracellular domain of human Notch3 receptor protein wherein X is...
Lead compound for otoprotection: targeting HGF signaling with dihexa
A novel method of preventing or reducing ototoxicity in vertebrates undergoing treatment with therapeutically effective amounts of platinum-based...
Fusion protein for enhancing immunogenicity of bacterial antigen/immunogen
Establishment of an effective and uniform vaccine development strategy is key to conquering current and emerging infectious diseases. Despite successes against...
Method for producing web protein, a fused protein, recombinant DNA, an
expression vector, a host cell and...
The invention relates to the field of biotechnology and provides a method for producing recombinant proteins from the orb-weaving spider silk in yeast cells....
High MAST2-affinity polypeptides and uses thereof
The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of...
Methods for treatment of nephrotic syndrome and related conditions
The present disclosure provides a method for treating and/or preventing a condition characterized as a nephrotic syndrome, such as but not limited to minimal...
Brassica plant comprising a mutant INDEHISCENT allele
This invention relates to crop plants of which the fruit dehiscence properties are modulated. More specifically the invention relates to improved methods and...
Fermentation process for producing a virulence factor from bordetella
A process for fermenting Bordetella species comprising incubating a sample of bacteria of a Bordetella species in a first environment under at least one bvg...
Insecticidal proteins and methods for their use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
Conjugated Vi saccharides
Two Vi conjugates have been prepared by carbodiimide-mediated synthesis, using adipic acid dihydrazide derivatized CRM.sub.197 (a non-toxic variant of...
Modified virus vectors and methods of making and using the same
The present invention provides AAV capsid proteins (VP1, VP2 and/or VP3) comprising a modification in the amino acid sequence in the three-fold axis loop 4 and...
Method for producing bio-active agent for the prevention of disease caused
by White Spot Syndrome Baculovirus...
A method of producing an agent capable of eliciting immune response against White Spot Syndrome Baculovirus complex in crustaceans of Penaeidae family upon...
Antimicrobial peptide WY-21 and application thereof
An antimicrobial peptide WY-21 has amino acid sequence of Val-Lys-Phe-Phe-Arg-Lys-Leu-Lys-Lys-Ser-Val-Lys-Glu-Lys-Ile-Gly-Lys-Glu-P- he-Lys-Arg (SEQ ID NO: 1)....
Hexadepsipeptide analogues as anticancer compounds
This invention relates to an isolated compound of Formula (1) ##STR00001## or derivatives or pharmaceutically acceptable salts thereof. The invention also...
Melanoma antigen peptide and uses thereof
The present invention relates to a melanoma antigen peptide comprising the amino acids sequence selected in the group consisting of SEQ ID NO: 10, SEQ ID NO:...
Protease-resistant compounds useful as shuttles through the blood-brain
barrier and shuttle-cargo constructs
The peptides of formula (I) where: R.sub.1 is the group attached to the N-terminal of the first amino acid of the sequence P, optionally via the ligand X, and...
Peptide-based inhibitor of interleukin-10 or interferon-gamma signaling
A peptide or peptidomimetic comprising an amino acid sequence based on conserved regions of IL10 or IFN-gamma receptor sequences, and related compounds and...
Process for purification of a fatty acid binding protein
A process for purification of a fatty acid binding proteins such as, e.g., Sm14 of Pichia pastoris or type-3 FABP protein of Fasciola hepatica. The process...
Process for the synthesis of therapeutic peptides
The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase...
Protopanoxadiol derivative, preparation method thereof and application
The present invention provides a protopanoxadiol derivative of structural formula I or II, a preparation method and an application thereof. The present...
Synthetic intermediate of
1-(2-deoxy-2-fluoro-4-thio-.beta.-D-arabinofuranosyl) cytosine, synthetic
A compound represented by a formula [1D] as shown below (wherein R.sup.1A, R.sup.1B, R.sup.2A, R.sup.2B, R.sup.3A and R.sup.3B represent a hydrogen atom, an...
Anticancer agents of the anthracyclin family
Anthracyclin compounds of the general structure: ##STR00001## are disclosed. In these compounds R.sup.1 is methyl, acetyl or hydroxyacetyl; R.sup.2--R.sup.5...
Method for lignin separation from black liquor comprising removal of
sulfur compounds from formed water effluent
The method is for separation of lignin from original black liquor (BL.sub.IN) having a first precipitation phase (PR1/PR2) for precipitation of lignin by a...
Phosphonates with reduced toxicity for treatment of viral infections
There are provided, inter alia, acyclic nucleoside phosphonate compounds having reduced toxicity and enhanced antiviral activity, and pharmaceutically accepted...
Formylpyrrole-based heterocycles for nucleic acid attachment to supports
A compound has Formula I: ##STR00001## A, B, C, D, W, X, Y, and Z are independently selected from hydrogen, optionally substituted C.sub.1-C.sub.6 alkyl,...
Concentrated therapeutic phospholipid compositions
The invention relates to concentrated therapeutic phospholipid compositions; methods for treating or preventing diseases associated with cardiovascular disease,...
Method for the hydrosilylation of a siloxane photocatalysed by a
The invention concerns a method of hydrosilylation between a siloxane compound (A) comprising at least one hydrogen atom bonded to a silicon atom and an...
Organopolysiloxane and use thereof as surfactant, powder treatment agent,
thickening agent of oil-based raw...
The present invention provides a co-modified organopolysiloxane having a specified chemical structure in which a sugar alcohol-modified group and a silylalkyl...
Tris(trimethyl siloxyl)silane vinylic monomers and uses thereof
The invention provides a TRIS-containing vinylic monomer which comprises one sole (meth)acryloyloxy group and a tris(trimethylsiloxy)silyl group covalently...
Fluorine-containing nano composite particles and method for producing the
Fluorine-containing nano composite particles comprising a condensate of a fluorine-containing alcohol represented by the general formula: R.sub.F-A-OH [I]...
therapeutic uses thereof
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
Fused pyrimidines as inhibitors of p97 complex
Disclosed are fused pyrimidine compounds having scaffolds composed of left and right rings, the left ring being a saturated carbocyclic or heterocyclic ring and...
Methods for the preparation of hydromorphone
The present application relates to methods for the preparation of morphine derivatives. In particular, the present application relates to methods for the...
Substituted 2- amidoquinazol-4-ones as matrix metalloproteinase-13
The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a...
Process for preparation of Darunavir
Provided are a process for preparation of darunavir or solvates or a pharmaceutically acceptable salt thereof substantially free of bisfuranyl impurities and a...
Substituted imidazo[1,2-a]pyrazines as TNF activity modulators
A series of imidazo[1,2-a]pyrazine derivatives, being potent modulators of human TNF.alpha. activity, are accordingly of benefit in the treatment and/or...
Substituted 7-azabicycles and their use as orexin receptor modulators
The present invention is directed to compounds of Formula I: ##STR00001## wherein ring A is phenyl, naphthalenyl, pyridyl, quinolinyl, isoquinolinyl,...
Selective PI3K delta inhibitors
The present invention relates to selective inhibitors of PI3K delta protein kinases, methods of preparing them, pharmaceutical compositions containing them and...
Pyrazole substituted imidazopyrazines as casein kinase 1 d/e inhibitors
The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity...
Disclosed are compounds of Formula 1, ##STR00001## and pharmaceutically acceptable salts thereof, wherein L, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5,...
Substituted benzothienyl-pyrrolotriazines and uses thereof
This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory...
nes as selective NK-3 receptor...
The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis...
Tricyclic pyrrolopyridine compound, and JAK inhibitor
To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly...