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Patent # Description
US-9,475,812 Pyridonaphthyridine type dual PI3K and mTOR inhibitor and its preparation and use
The present invention relates to a pyridonaphthyridine compound as represented by general formula (I), which has a dual PI3K and mTOR inhibition effect, and its...
US-9,475,811 1-aza-bicyclo[3.3.1]nonanes
The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I); wherein the substituents are as defined in the specification, to processes for...
US-9,475,810 Compounds and formulations suitable for radical scavenging
The present invention relates to compositions and methods of using free radical scavengers with reduced .sup.1O.sub.2 generation. In certain embodiments, these...
US-9,475,809 Substituted oxopyridine derivatives and use thereof as factor xia/plasma
The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the...
US-9,475,808 Inhibitor compounds of phosphodiesterase type 10A
The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof: ...
US-9,475,807 2-(1H-indazol-3-yl)-1H-imidazo[4,5-C]pyridine and therapeutic uses thereof
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
US-9,475,806 Complement factor B inhibitors and uses there of
The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as...
US-9,475,805 Tricyclic compound
The invention provides a method of activating PPAR .gamma. and a method of treating or preventing a disease associated with PPAR .gamma. by administering a...
US-9,475,804 Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
Conjugates of an immune response modifier, a linker, and an antigen are disclosed. The linker is represented by formula (I): wherein A is CH or N, p is in a...
US-9,475,803 Sweet flavor modifier
The present invention includes compounds having structural formula (Ia): ##STR00001## or salts or solvates thereof. These compounds are useful as sweet...
US-9,475,802 Inhibitors of viral replication, their process of preparation and their therapeutical uses
Inhibitors of viral replication of formula (I), their process of preparation and their therapeutical uses. The present invention relates to compounds, their use...
US-9,475,801 Compounds as tyrosine kinase modulators
The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are...
US-9,475,800 Azetidine derivatives
Compounds of formula (I) are inhibitors of fatty acid amide hydrolase, (FAAH), and which are useful in the treatment of diseases or medical conditions which...
US-9,475,799 Synthesis of Raltegravir
The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from...
US-9,475,798 Azetidine estrogen receptor modulators and uses thereof
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds...
US-9,475,797 Phenyl triazole derivative and its use for modulating the GABA.sub.A receptor complex
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The...
US-9,475,796 1-pyrazolyl-3-((4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as p38 MAP kinase inhibitors
There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy,...
US-9,475,795 Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) in which m, n, W, X, Y, Z, R.sup.1, R.sup.2, R.sup.3...
US-9,475,794 Process for the preparation of polymorphs of imidacloprid
A process for the preparation of a Form I crystalline polymorph of imidacloprid, including: (i) dissolving imidacloprid in an appropriate amount of aqueous...
US-9,475,793 Conjugates and associated methods of producing them for the prevention or treatment of nicotine addiction
The present invention relates in part to chemical compounds, and methods for producing these compounds. The compounds may also be incorporated into compositions...
US-9,475,792 Materials for organic electroluminescence devices
The present invention describes indenofluorene derivatives of the general formula I, II, III or IV having emitting and hole-transporting properties, in...
US-9,475,791 Compositions and methods for treating estrogen-related medical disorders
Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of...
US-9,475,790 Method for preparing refined lactide from recovered polylactic acid
A method for preparing lactide from recovered polylactic acid, the method including the following steps: A. pretreating the recovered polylactic acid; B....
US-9,475,789 Use of polyenylpyrrole derivatives for treating inflammation
The preset invention relates to a method for treating inflammation comprising administering a subject in need thereof with a therapeutically effective amount of...
US-9,475,788 Antiprotozoal compounds
The invention is directed to a compound of formula I, a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing a compound of formula...
US-9,475,787 Process for the production of furan derivatives
A process for the production of furan derivatives from carbohydrates in the presence of an acidic catalyst, characterized in that N-methylpyrrolidone is used as...
US-9,475,786 Method for synthesising 2,5-di(hydroxymethyl)furan and 2,5-di(hydroxymethyl)tetrahydrofuran by selective...
A method for selective hydrogenation of furan-2,5-dialdehyde (DFF) into 2,5-di(hydroxymethyl)furan (DHMF) and into 2,5-di(hydroxymethyl)tetrahydrofuran...
US-9,475,785 Iminothiadiazine dioxide compounds as BACE inhibitors, compositions and their use
In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): ##STR00001## and include...
US-9,475,784 4,6-diarylaminothiazines as BACE1 inhibitors and their use for the reduction of beta-amyloid production
Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: wherein R.sup.1 and R.sup.2 are independently hydrogen, or...
US-9,475,783 Antimicrobial agents
The invention provides compounds of formula (I): ##STR00001## wherein R.sup.1-R.sup.7 and W have any of the values defined in the specification, and salts...
US-9,475,782 Guanidine compounds, and use thereof as binding partners for 5-HT5 receptors
The present invention relates to guanidine compounds of the general formula I ##STR00001## corresponding enantiomeric, diastereomeric and/or tautomeric forms...
US-9,475,781 Fumarate analogs and uses thereof
Aspects of the present disclosure include compounds that find use for the treatment of a variety of autoimmune and inflammatory diseases and disorders....
US-9,475,780 Process for the synthesis of cyclic alkylene ureas
The invention relates to a process for the synthesis of cyclic alkylene ureas comprising reacting in the presence of a basic catalyst, a difunctional amine A...
US-9,475,779 Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
Substituted bicyclic dihydropyrimidinones of formula 1 ##STR00001## which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of,...
US-9,475,778 Sulfate of 5-hydroxy-1H-imidazole-4-carboxamide
Sulfate of 5-hydroxy-1H-imidazole-4-carboxamide has such characteristics as suppressed blue coloring, high purity, low hygroscopic property, and superior...
US-9,475,777 Thermally robust, highly porous, and partially fluorinated organic framework with affinity for hydrocarbons,...
Porous partially fluorinated materials which bind aliphatic and aromatic hydrocarbons, fluorocarbons and freons with high weight adsorption capacities are...
US-9,475,776 PRMT1 inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein...
US-9,475,775 Benzazepine dicarboxamide compounds
This invention relates to novel benzazepine dicarboxamide compounds of the formula ##STR00001## wherein R.sup.1 to R.sup.4 are as defined in the description...
US-9,475,774 Alpha-hydrogen substituted nitroxyls and derivatives thereof as catalysts
Novel alpha-hydrogen substituted nitroxyl compounds and their corresponding oxidized (oxoammonium cations) and reduced (hydroxylamine) forms, and the use of...
US-9,475,773 NK3 receptor antagonist compound (NK3RA) for use in a method for the treatment of polycystic ovary syndrome (PCOS)
A method for treating polycystic ovarian syndrome and related conditions with a compound (I): or a pharmaceutically acceptable salt thereof. ##STR00001##
US-9,475,772 Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof
The invention relates to new and improved processes for the preparation of Indacaterol and pharmaceutically acceptable salts thereof as well as intermediates...
US-9,475,771 Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids
4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and...
US-9,475,770 Low-temperature synthesis of methylphenidate hydrochloride
The present invention describes a process for the preparation of methylphenidate hydrochloride. The process involves the esterification of ritalinic acid and...
US-9,475,769 Zinc halide mediated cyclization process leading to tricyclic indoles
The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over...
US-9,475,768 Luminogen compounds and the use of the same for biosensing and cellular imaging
Provided herein are a luminogen compound of formula (I) including a AIE luminophore moiety conjugated with a maleimide moiety and a use of the same for...
US-9,475,767 Polyurethane (meth) acrylates using modified hydroxythiols
The invention provides intermediates of the formula: ##STR00001## as well as a method of their preparation by reacting a thiol having at least two hydroxyl...
US-9,475,766 Substituted aromatic sulfur compounds and methods of their use
Compounds of formula II are described: ##STR00001## wherein D, n, R.sub.a, R.sub.b, and R.sub.c are as herein defined, along with pharmaceutical compositions...
US-9,475,765 Polymorphs of N- (2 -methoxybenzoyl) -4- [ (methylaminocarbonyl) amino] benzenesulfonamide
The present invention relates to solid forms of herbicide safeners, to processes for their preparation, compositions comprising the solid forms and methods of...
US-9,475,764 Synthesis of tetrabutylammonium bis(fluorosulfonyl)imide and related salts
The present invention is directed to methods comprising adding ammonia, either as an ammonium salt or as a gas at pressures below 0.01 MPa, to a sulfuryl...
US-9,475,763 Photoresist comprising nitrogen-containing compound
New nitrogen-containing compounds are provided that comprise multiple hydroxyl moieties and photoresist compositions that comprise such nitrogen-containing...
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