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Patent # Description
US-9,481,714 Fusion proteins for use as immunogenic enhancers for inducing antigen-specific T cell responses
A fusion protein for use as an immunogen enhancer for enhancing antigen-specific T cell responses is disclosed. The fusion protein comprises: (a) an...
US-9,481,713 Self-assembling peptides incorporating modifications and methods of use thereof
The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The...
US-9,481,712 Peptidomimetics possessing photo-controlled biological activity
The present invention relates to pharmaceutically and/or diagnostically active compounds, in particular peptide analogs (peptidomimetics), which can be...
US-9,481,710 Evaluation peptide for use in quantification of protein using mass spectrometer, artificial standard protein,...
Disclosed is an evaluation peptide for evaluating the efficiency of a pretreatment in the quantification of a protein using a mass spectrometer, having high...
US-9,481,709 Boropeptide inhibitors of enteropeptidase and their uses in treatment of obesity, overweight and/or diseases...
Novel compounds, particularly derivatives of boroarginine, boroornithine and borolysine that selectively modulate, regulate, and/or inhibit enteropeptidase....
US-9,481,708 Process for producing Sovaprevir
The disclosure includes novel processes for producing Sovaprevir comprising adding ##STR00001## compound E to F-1 to provide Sovaprevir. The disclosure...
US-9,481,707 .alpha.-oxoacyl amino-caprolactam derivative
The purpose of the present invention is to provide a pharmaceutical composition that is useful for the treatment of diseases that are caused by an increase in...
US-9,481,706 Purification of non-glycosylated polypeptides
The current invention reports a method for the purification of a not-glycosylated, heterologous polypeptide, which has been recombinantly produced in a...
US-9,481,705 Modular radiochemistry synthesis system
A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote...
US-9,481,704 2'-substituted carba-nucleoside analogs for antiviral treatment
Provided are compounds of Formula I, ##STR00001## as well as pharmaceutical compositions containing compounds of Formula I and methods for treating...
US-9,481,703 HCV polymerase inhibitors
The invention provides compounds of the formula: ##STR00001## wherein B is a nucleobase selected from the groups (a) to (d): ##STR00002## and the other...
US-9,481,702 Glycoside compound, method for producing thioether, ether, method for producing ether, method for producing...
The invention provides a glucoside compound, which is capable of providing a phosphoramidite, which can be produced at low cost and can produce a nucleic acid...
US-9,481,701 Method for 2-sulfation of glycosides
Method for selective 2-sulfation of glycosides.
US-9,481,700 Method for preparing isofagomine and its derivatives
A method for preparing isofagomine, its derivatives, intermediates and salts thereof using novel processes to make isofagomine from D-(-)-arabinose and...
US-9,481,699 Platinum(II) complexes with thione ligands and methods thereof
Platinum(II) complexes having thione-based heterocyclic ligands as anticancer agents. The central platinum atom is coordinated by four of the ligands, each...
US-9,481,698 Process for preparing ceftaroline fosamil
The present invention relates to a novel process for preparing ceftaroline fosamil as well as to intermediates of this process.
US-9,481,696 Thiophosphates and thiophosphate derivatives as lubricant additives
The present invention provides thiophosphates and thiophosphate derivatives useful as antiwear additive components, lubricant additive compositions and...
US-9,481,695 Amino acid-modified siloxanes, process for preparing them and application
A process for preparing amino acid-modified siloxanes that can be carried out under mild conditions is provided as well as organically modified silicones for...
US-9,481,694 Solid solution pigment nanoparticles and method for producing solid solution pigment nanoparticles having...
The problem addressed by the present invention is to provide; solid solution pigment nanoparticles having a homogeneous solid solution ratio; a method for...
US-9,481,693 Mixed ligand gold(III) complexes as anti-cancer agents
Gold(III) complexes with mixed ligands as anticancer agents. The gold(III) cations are coordinated to bidentate ligands having diamino functional groups: a...
US-9,481,692 Heterocyclic modulators of HIF activity for treatment of disease
The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and...
US-9,481,691 CDK inhibitors
Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
US-9,481,690 Polymorphs of 2-(4-(2-(1-(isopropyl-3-methyl-1H-1,2,4,triazol-5-yl)-5,6-dihydrobenzo[f] ...
The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]- ...
US-9,481,689 sGC stimulators
Compounds of Formulae I' and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds...
US-9,481,688 (Thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT.sub.2A...
A dual H1/5-HT.sub.2A receptor antagonist of the formula: ##STR00001## its uses, and methods for its preparation are described.
US-9,481,687 IRAK inhibitors and uses thereof
The present invention provides arylo-fused thienopyrimidine compounds, compositions thereof, and methods of using the same.
US-9,481,686 Process for preparing enantiomerically enriched oxamides
The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof....
US-9,481,685 Imaging neuroinflammation
The present invention concerns in vivo imaging and in particular in vivo imaging of the peripheral benzodiazepine receptor (PBR). A tetracyclic indole in vivo...
US-9,481,684 Gonadotropin releasing hormone receptor antagonists, method for the preparation thereof and pharmaceutical...
Disclosed are a gonadotropin releasing hormone receptor antagonist and a pharmaceutical composition including the same, which can be useful in preventing or...
US-9,481,683 1,3-benzothiazinone sulfoxide and sulfone compounds
A compound, having the following formula: ##STR00001## or resonance form thereof, or salt thereof, or salt of resonance form thereof is provided, wherein...
US-9,481,682 Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to...
US-9,481,681 Dihydroetorphines and their preparation
The present invention provides a process for the preparation of a compound of formula (VI), or a salt or derivative thereof, ##STR00001## wherein R.sup.1 and...
US-9,481,680 Process for the preparation of key intermediates of omarigliptin
An improved process for the preparation of a key intermediate for the synthesis of the active ingredient Omarigliptin is provided. The key intermediate is a...
US-9,481,679 Process for the preparation of tofacitinib and intermediates thereof
The present invention provides compounds of Formula III and Formula VI, and processes for their preparation. The present invention further provides use of the...
US-9,481,678 Substituted pyrrolo[2,3-D]dipyrimidines for selectively targeting tumor cells with FR-alpha and FR-beta type...
Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These...
US-9,481,677 Biaryl ether sulfonamides and their use as therapeutic agents
This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention...
US-9,481,676 Azepino[4,5-B]indoles and methods of use
This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described,...
US-9,481,675 Gyrase inhibitors
Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula I are disclosed: ##STR00001## ...
US-9,481,674 Dihydropyrrolopyridine inhibitors of ROR-gamma
Provided are novel compounds of Formula (I): ##STR00001## pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful...
US-9,481,673 6-alkynyl-pyridine derivatives
6-Alkynyl-pyridine of general formula (I) ##STR00001## their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments...
US-9,481,672 Bicyclically substituted uracils and the use thereof
The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in...
US-9,481,671 Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
A method of treating a glomerular disease selected from the group consisting of mesangial proliferative glomerulonephritis, collapsing glomerulopathy,...
US-9,481,670 Triazine compounds
The present invention relates to novel triazine compounds of formula (1), methods of their preparation, pharmaceutical compositions containing these compounds...
US-9,481,669 Pladienolide pyridine compounds and methods of use
The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds...
US-9,481,668 Quinoline inhibitor of the macrophage stimulating 1 receptor MSTR1
The compound N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-5-ethyl-1 -(pyrimidin-5-yl)-1H-pyrazole-4-carboxamide ##STR00001## and ...
US-9,481,667 Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of...
US-9,481,666 Substituted dihydroisoquinolinone compounds
This invention relates to compounds of general formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, L, X and Z are as defined herein, and...
US-9,481,665 Process for preparing PI3K inhibitor buparsilib
The present disclosure provides a new process for preparing PI3K inhibitor buparsilib. The whole reaction route of the present invention is simple and easy to...
US-9,481,664 Androgen receptor modulators and uses thereof
Described herein are compounds that are androgen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds...
US-9,481,663 Crystalline forms of an androgen receptor modulator
Described herein are amorphous and crystalline forms of the androgen receptor modulator ...
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