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Patent # Description
US-9,486,470 Compositions including triciribine and one or more platinum compounds and methods of use thereof
This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced...
US-9,486,469 STAT5a and its functional tumor suppressor analogs for treatment of malignancies expressing NPM/ALK and other...
The invention provides methods of inhibiting epigenetic gene silencing in a cell expressing NPM/ALK or decreasing NPM/ALK content in a cell, by contacting a...
US-9,486,468 Compositions including anthocyanin or anthocyanidin for the prevention or treatment of articular...
Methods of treating an arthritic joint of a subject, including administering a pharmaceutical composition by injection into the arthritic joint, wherein the...
US-9,486,467 Method of treating colorectal cancer that expresses a mutated APC gene by administering erythromycin or tylosin
The present invention includes methods for treating or preventing a cancer in a mammal comprising administering to the mammal a therapeutically effective amount...
US-9,486,466 Veliparib in combination with carboplatin for the treatment of triple negative breast cancer
The invention relates to a method for the treatment of triple negative breast cancer in a subject, comprising administering to the subject an effective amount...
US-9,486,465 Attractant for bone marrow stem cells and method for attracting bone marrow stem cells
Provided are an attractant for bone marrow stem cells containing at least one of cinnamtannin B1 and pentagalloylglucose, and a method for attracting bone...
US-9,486,464 Composition and method of manufacture
A dietary supplement composition includes a synergistic combination of saffron and resveratrol for providing anti-oxidant and gene modulation effects for...
US-9,486,463 Chemosensory receptor ligand-based therapies
Provided herein are methods of modulating hormone concentrations in a subject comprising the administration of a composition comprising a chemosensory receptor...
US-9,486,462 Formulations of aminoglycosides and fosfomycin in a combination having improved chemical properties
The present invention is synergistic antibiotic compositions having pH adjusted profiles for manufacturing combination, and administration, particularly for...
US-9,486,461 Methods and compositions for inducing apoptosis by stimulating ER stress
The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a...
US-9,486,460 Bismuth containing liquid pharmaceutical suspensions
A liquid pharmaceutical suspension for oral administration containing a bismuth-containing pharmaceutical agent, a suspension system, and water. The suspension...
US-9,486,459 Porous silicon drug-eluting particles
The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the...
US-9,486,458 Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
The present invention refers to a new enzymatic process for obtaining 17.alpha.-monoesters of cortexolone and/or its 9,11-dehydroderivatives starting from the...
US-9,486,457 Use of cinnabarinic acid as a modulator of immune responses in autoimmune disorders
The present invention provides compounds and methods for preventing and treating an immune disorder in a subject.
US-9,486,456 Treatment of esophageal motility disorder using sepiapterin, tetrahydrobiopterin and derivatives thereof
The present invention discloses that diabetic rats showed a reduction in nitrergic relaxation of the gastric, impaired nNOS dimerization, decreased BH4 and...
US-9,486,455 Compounds for modulating TRPV3 function
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
US-9,486,454 Hydrazaline hydrochloride pellets and method of preparation
Embodiments of a hydrazaline hydrochloride composition for treatment of hypertension in humans each provide sustained release of hydralazine hydrochloride...
US-9,486,453 Composition and method for treatment of depression and psychosis in humans
Compositions and methods for the treatment of depression and psychoses in humans are disclosed. More particularly, the invention is directed to formulations...
US-9,486,452 Product and method for treating diarrhea
A method of treating diarrhea in a patient includes administering an H1 receptor antagonist and an H2 receptor antagonist to the patient.
US-9,486,451 Abuse resistant pharmaceutical compositions
The present invention relates to a composition comprising pharmaceutical active ingredients which are susceptible to, or have potential for, abuse. The...
US-9,486,450 Hydroxybupropion and related compounds as modulators of drug plasma levels
This disclosure relates to methods administering hydroxybupropion or a prodrug thereof in conjunction with dextromethorphan to a human being. Dosage forms, drug...
US-9,486,449 Cancer therapy
The subject invention provides for cancer therapy.
US-9,486,448 Pyrrolidine derived beta 3 adrenergic receptor agonists
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of...
US-9,486,447 Compositions and methods for controlling neuronal excitation
Embodiments of the technology described herein relate, at least in part, to methods of modulating the activity of a neuron by contacting the neuron with a...
US-9,486,446 Orally disintegrating solid preparation
The present invention provides an orally-disintegrating solid preparation comprising fine granules showing controlled release of a pharmaceutically active...
US-9,486,445 Combination therapy for proliferative disorders
Treatment of proliferative diseases with a combination of a b-Raf inhibitor and MDM2 inhibitor.
US-9,486,444 Anti-cancer compound
Anti-cancer compounds include N-arylmethylidene piperidones having structural formula I: ##STR00001## where R is a hydrogen, halogen, methyl, methoxy, or...
US-9,486,443 Pharmaceutical composition for preventing or treating hypertriglyceridemia or hypertriglyceridemia-associated...
The present invention is a method for treating hyperlipidemia comprising (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(p- ...
US-9,486,442 Methods for treating or preventing brain infections
The invention is directed to methods of treating organ specific infections in a host organism by administering compounds that target host receptors and/or host...
US-9,486,441 Compounds, compositions and methods for making the same
The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful...
US-9,486,440 Uses of indole-ketones or indolidones as neuro-protective drugs
The present invention provides a method of using indole-ketone or indolidone such as SU4312, SU5416, SU11248 (Sunitinib), or indirubin-3-oxime to treat a...
US-9,486,439 Use of NK-1 receptor antagonist serlopitant in pruritus
The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical...
US-9,486,438 Combination dosage forms and therapies for supporting bone health
Combined therapies and oral dosage forms based on genistein for the support of osteoporotic health.
US-9,486,437 Methods of using low-dose doxepin for the improvement of sleep
Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g.,...
US-9,486,436 Method for making bismuth containing liquid pharmaceutical suspensions
A method of producing a liquid pharmaceutical suspension by mixing magnesium aluminum silicate, gellan gum, bismuth subsalicylate, and methyl cellulose.
US-9,486,435 (Het)aryl-p-quinone derivatives for treatment of mitochondrial diseases
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial...
US-9,486,434 Method for delivery and use of isothiocyanates for prophylaxis and/or therapy of bladder cancer
Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is...
US-9,486,433 Compositions and methods for treating non-alcoholic steatohepatitis
Compositions and method are disclosed comprising ethyl icosapentate for use in treatment of non-alcoholic steatohepatitis (NASH).
US-9,486,432 Compositions and methods for treating macular degeneration
Methods of retarding formation of a lipofuscin pigment in the retina and of treating or ameliorating the effects of a disease characterized by an accumulation...
US-9,486,431 Drug delivery medical device
Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one...
US-9,486,430 Treatment of neurodegenerative disease
A method for reducing alpha-synuclein amyloid protein in a patient suffering from Parkinson's Disease comprising administering to the patient an effective...
US-9,486,429 Therapeutic methods employing nitric oxide precursors
Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well...
US-9,486,428 Treatment of intrahepatic cholestatic diseases
Treatment of intrahepatic cholestatic diseases by therapy with MBX-8025 or an MBX-8025 salt.
US-9,486,427 Administration of aerosolised iloprost
The present invention relates to novel methods, compositions and kits useful for the treatment of pulmonary diseases such as pulmonary arterial hypertension. In...
US-9,486,426 Method of administration of gamma hydroxybutyrate with monocarboxylate transporters
One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient. It has been...
US-9,486,425 4-oxo-2-pentenoic acid and liver disorders
The present invention relates generally to compositions with a health benefit. In particular, the invention relates to treatment or prevention of liver...
US-9,486,424 Creatine oral supplementation using creatine hydrochloride salt
The present invention is directed to a third generation form of creatine, specifically a creatine hydrochloride salt, that drives significant improvements in...
US-9,486,423 Redox-directed chelators targeting intracellular metal ions
The present invention provides redox-activated chelators and methods for using the same to treat cancer. In one particular embodiment, the redox-activated...
US-9,486,422 Small molecule inhibitors of Mcl-1 and the uses of thereof
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having ...
US-9,486,421 Treatment of lung cells with histone deacetylase inhibitors
Lung disease, such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), asthma or acute and chronic bronchitis, can be treated with an...
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