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Patent # Description
US-9,487,815 Means and methods for the determination of (D)-2-hydroxyglutarate (D2HG) or (D)-2-hydroxyadipic acid
The present invention relates to a method for detecting (D)-2-hydroxyglutarate or (D)-2-hydroxyadipic acid in a sample, the method comprising the steps of: a)...
US-9,487,814 Stabilized formulation for luminescent detection of luciferase and nucleoside phosphates
Methods, kits and compositions containing a mixture of D-luciferin and L-luciferin for light generation with luciferase are disclosed that have improved...
US-9,487,812 Optical alignment deformation spectroscopy
A microfluidic system, device, and method are disclosed. The microfluidic system may include a first microfluidic channel and a second microfluidic channel,...
US-9,487,811 Biosensor structures for improved point of care testing and methods of manufacture thereof
The present invention relates to analytical testing devices and methods for fabricating electrochemical creatinine biosensors, and in particular using point of...
US-9,487,810 Methods of cell culture
Polypeptide preparations having target levels of glycans, and methods of producing such polypeptide preparations using DMSO, are described.
US-9,487,808 Rapid assembly of multiple arbitrary length DNA fragments
Aspects herein relate to composition, and related methods, for isolating and assembling DNA molecules without intermediate cloning steps.
US-9,487,807 Compositions and methods for producing single-stranded circular DNA
The present invention provides methods, kits, and compositions for producing single-stranded circular DNA by PCR. In particular, hairpin primers are provided,...
US-9,487,806 Method for producing L-amino acid
A method for producing of an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and...
US-9,487,805 Betaine esters and process for making and using
A variety of betaine esters, including dialkylaminoalkyl cocoate betaines and dialkylaminoalkyl hydrogenated cocoate betaines are disclosed. These betaines can...
US-9,487,803 Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic...
US-9,487,801 Biocontrol
Provided is an arthropod male germline gene expression system suitable for conditional expression of an effector gene in an Arthropod male germline. The system...
US-9,487,800 Interleukin 15 as selectable marker for gene transfer in lymphocytes
The present invention relates to the use of interleukin-15 (IL-15) as selectable marker for gene transfer, preferably of at least one gene of therapeutic...
US-9,487,799 Inbred tomato line PSQ 23-2293
The invention provides seed and plants of tomato line PSQ 23-2293. The invention thus relates to the plants, seeds and tissue cultures of tomato line PSQ...
US-9,487,798 DIG-10 insecticidal cry toxins
DIG-10 Cry toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are disclosed.
US-9,487,797 Genomic plant sequences and uses thereof
The present invention discloses rice genomic promoter sequences. The promoters are particularly suited for use in rice and other cereal crops. Methods of...
US-9,487,796 Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
Isolated polynucleotides having a nucleic acid sequence at least 80% homologous to SEQ ID NO:1, 3, 5, 7, 9, 11, 158, 159, 160, 161, 162-204, 206-211, 214-287...
US-9,487,795 Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield, biomass, oil...
Provided are isolated polynucleotides which comprise a nucleic acid sequence encoding a polypeptide which exhibits at least 94% sequence identity to SEQ ID NO:...
US-9,487,794 Feruloyl-CoA:monolignol transferase
The invention relates to nucleic acids encoding a feruloyl-CoA:monolignol transferase and the feruloyl-CoA:monolignol transferase enzyme that enables...
US-9,487,793 Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants
Provided are method of increasing oil content, growth rate, biomass, yield and/or vigor of a plant. The methods are effected by upregulating in the plant an...
US-9,487,792 Regulatory sequences to control gene expression in plants
The present invention discloses regulatory sequences, promoters and terminators, and their use in plants. The regulatory sequences can be used to make gene...
US-9,487,791 Method for improved protein production in filamentous fungi
The present invention relates to a method for genetically modifying a filamentous fungus host for improved protein production. The method comprises that a...
US-9,487,790 Nuclear based expression of genes for production of biofuels and process co-products in algae
Various embodiments provide, for example, vectors, expression cassettes, and cells useful for transgenic expression of nucleic acid sequences. In various...
US-9,487,789 E. coli plasmid DNA production
General methods and strains of bacteria are described that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin...
US-9,487,788 E. coli plasmid DNA production
General methods and strains of bacteria are described that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin...
US-9,487,787 Method for regulating protein function in cells using synthetic small molecules
Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described....
US-9,487,786 Immunosuppression compound and treatment method
A method and compound for suppressing an immune response in a mammalian subject, for the treatment or prevention of an autoimmune condition or transplantation...
US-9,487,785 Multi-targeting short interfering RNAs
The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to...
US-9,487,784 Antisense antibacterial method and compound
A method and antisense compound for inhibiting the growth of pathogenic bacterial cells are disclosed. The compound contains no more than 12 nucleotide bases...
US-9,487,783 Targeting microRNAs for metabolic disorders
Described herein are compounds comprising modified oligonucleotides that are complementary to miR-103 and/or miR-107 and methods of treating diseases and...
US-9,487,782 Methods for the treatment of leber congenital amaurosis
The present invention relates to a method for treating a Leber congenital amaurosis in a patient harboring the mutation c.2991+1655 A>G in the CEP290 gene,...
US-9,487,781 Compositions and methods for treatment of ovarian cancer
The disclosure provides compositions and methods for treating an ovarian cancer in a subject. More specifically, the disclosure provides microRNA (miRNA)...
US-9,487,780 Antisense compounds targeting genes associated with fibronectin
Provided are compounds comprising oligonucleotides complementary to a fibronectin transcript. Certain such compounds are useful for hybridizing to a fibronectin...
US-9,487,779 siRNA-mediated gene silencing
The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
US-9,487,778 Oligonucleotide modulators of the toll-like receptor pathway
Disclosed herein are double stranded nucleic acid molecules and pharmaceutical compositions comprising same useful in the treatment of, inter alia, acute and...
US-9,487,777 RNAi probes targeting cancer-related proteins
RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal...
US-9,487,776 Method of identifying myelodysplastic syndromes
Myelodysplastic syndromes display both hematological and biological heterogeneity with variable leukemia potential. To determine whether microRNAs expression...
US-9,487,775 Method for the synthesis of a bifunctional complex
Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex...
US-9,487,774 Compositions, methods, and kits for identifying candidate molecules from encoded chemical libraries
The subject matter relates to relates to a one-bead-one-sequence composition, a library of tagged chemicals comprising a plurality of one-bead-one-sequence...
US-9,487,773 Cell-based methods for coupling protein interactions and binding molecule selection
The invention relates to cell-based methods for diversifying, expressing and selecting binding molecules, e.g., antibodies, and target molecules to which they...
US-9,487,772 Inhibitors of human phosphatidylinositol 3-kinase delta
Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K.delta.) activity, and methods of treating diseases, such as disorders of immunity and...
US-9,487,771 Method of peptide hydrolysis, peptidase, the composition for use as a bacteriostatic and bactericidal agent, a...
The invention relates to new method of peptide hydrolysis, in particular of the cell walls of Gram-positive bacteria, wherein the active form of LytM or...
US-9,487,770 Recombinant cellulase and use thereof
The present invention provides Hahella chejuensis-derived recombinant cellulase and a use thereof. The recombinant cellulase according to the present invention...
US-9,487,769 Alpha-amylase mutants
The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one...
US-9,487,768 Methods and products for expressing proteins in cells
The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to...
US-9,487,767 Selection in fungi
The present invention relates to methods for constructing a recombinant fungal host cell comprising one or more copies of a polynucleotide construct integrated...
US-9,487,766 Therapeutic strategies to treat CNS pathology in mucopolysaccharidoses
The invention provides for nucleotide sequences encoding for a chimeric sulfatase, viral vectors expressing such sequences for gene therapy and pharmaceutical...
US-9,487,765 Stabilized transglutaminase and process for production thereof
Disclosed is a transglutaminase having excellent stability. Also disclosed is a process for producing the transglutaminase. Specifically disclosed is a...
US-9,487,764 Bacteria engineered to treat diseases associated with hyperammonemia
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are...
US-9,487,763 Nonribosomal peptide synthetases
The present disclosure is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS)-derived drug and analogs thereof. The invention...
US-9,487,762 Method and system for producing triterpenes
A method and system are provided for the production of triterpene including methylated triterpenes. The method and system include isolated nucleic acid...
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