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Methods for treating pancreatic cancer
The present disclosure is directed to methods of treating pancreatic cancer in subject using cancer with antibodies that specifically bind to progastrin.
Anti-CTLA-4 antibody compositions
The present invention provides for novel compositions of anti-CTLA-4 antibodies comprising a chelating agent. Also provided are method of treating diseases and...
Human IL-23 antigen binding proteins
Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same...
Methods and compositions for modulation of blood-neural barrier
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy...
Methods and compositions for targeting polyubiquitin
Anti-polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
Anti-glucosaminidase passive immunization for Staphylococcus aureus
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S....
Antigen specific multi epitope vaccines
The present invention relates to cancer vaccines composed of the signal peptide domain of tumor associated antigens or proteins. The peptide vaccines of the...
Murine anti-NY-ESO-1 T cell receptors
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides,...
Non-standard insulin analogues
An insulin analog comprises a B-chain polypeptide containing a cyclohexanylalanine substitution at position B24 and optionally containing additional amino-acid...
Glucagon antagonist-GIP agonist conjugates and compositions for the
treatment of metabolic disorders and obesity
Provided herein are peptide combinations comprising a GIP agonist peptide and a glucagon antagonist peptide. In some embodiments, the peptide combination is...
Glucagon like peptide analogs, composition, and method of use
The present invention relates to novel analogs of glucagon like peptide and compositions that are useful for up-regulating insulin expression in mammals and for...
Oxyntomodulin derivatives and pharmaceutical composition for treating
obesity comprising the same
The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native...
FGF-2 variants and methods of use thereof
A method of treating an individual (i) having abnormal bone; or (ii) afflicted with a disease or disorder related to normal or abnormal FGF receptors or a...
Method for the production of an immunostimulating mucin (MUC1)
The present invention relates to a method for producing or identifying a MUC1 molecule which is able to generate an immune response in humans. The invention...
Method for purifying protein
The present invention relates to protein purification. More particularly, a method for directly recovering an objective protein from a protein composition and...
Zein composition and methods of production
A high cysteine content zein composition is provided. A method and system for the manufacture of the bioproduct is likewise disclosed herein.
Virus-like particles and methods of use
The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the...
Stabilized polypeptides as regulators of RAB GTPase function
The present invention provides inventive polypeptides comprising a C terminal RAB binding domain (RabBD) of RAB family interacting proteins (FIPs) stabilized by...
Biologically active complex and its preparation
A biologically active complex comprising either a polypeptide having the sequence of a variant of a naturally occurring protein, wherein said polypeptide is at...
Angiogenic active lytic peptides
This invention relates to novel synthetic lytic peptide fragments of full-length peptides with the capacity to modulate angiogenic activity in mammals. The...
Short bio-active peptides for promoting wound healing
Peptides having four to six amino acid residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107...
Peptides for management of lactation
The present invention provides novel short peptides that are highly effective in inducing involution in a mammary gland of a lactating mammal and cessation of...
Prodrug of an ice inhibitor
This invention describes an ICE inhibitor prodrug (I) having good bioavailability. ##STR00001## Compound I is useful for treating IL-1 mediated diseases such...
Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, processes for their
The invention relates to AKR1C3 inhibitors and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to...
Method for preparing an extract of centella asiatica
The invention relates to a method for preparing a refined extract of Centella asiatica comprising a mixture of madecassoside and terminoloside. The method...
Small molecule compounds that control mammal-pathogenic nematodes
The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or...
Method of isolating purified RNA with reduced DNA contaminations
The present invention pertains to a method of isolating RNA from a sample comprising RNA, and DNA, comprising: a) adding an acidic denaturing composition...
Preparation of lignin
A method for the preparation of lignin from lignocellulosic material by pulping with alcohol, in particular with a C.sub.1-4 alcohol, water and a base, in...
Metal complexes comprising diazabenzimidazolocarbene ligands and the use
thereof in OLEDs
The present invention relates to metal-carbene complexes comprising a central atom selected from iridium and platinum, and diazabenzimidazolocarbene ligands, to...
Cyclic phosphinate derivatives and method of preparing the same
Provided are novel cyclic phosphinate derivatives and a method of preparing the same, and more particularly, cyclic phosphinate derivatives including...
Solid forms of tenofovir
The present invention relates to solid forms of tenofovir and methods for preparation, use and isolation of such forms.
Fused ring-containing oxazolidinones antibiotics
The present invention relates to a fused ring-containing oxazolidinone compound shown by general formula (I), a pharmaceutically acceptable salt thereof and a...
Methods for the preparation of diasteromerically pure phosphoramidate
Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: ##STR00001## The...
Silicone compound having a radical-polymerizable group and a method for
the preparation thereof
A silicon compound that contains a radical-polymerizable group. The silicone compound is liquid at room temperature and has good handling properties, has...
Mixed ligand gold(III) complexes and methods thereof
Gold(III) complexes having mixed ligands as anticancer agents. The atom is coordinated by bidentate ligands having diamino functional groups: a ...
Fused tricyclic ether carbamates and their use
Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds...
Compound for inhibiting the growth and proliferation of human liver cancer
cells and method for synthesizing it
The compound "2-((4-nitrophenyl)amino)-6,7,8,9-tetrahydro-3H-cyclohepta[4,5]thieno-[2,- 3-d]pyrimidin-4(5H)-one" and method of synthesizing it, wherein the ...
Compounds and therapeutic use thereof for protein kinase inhibition
Novel compound having the following formula: ##STR00001## wherein Y is N, O, or S. Also disclosed are a pharmaceutical compositions comprising the same,...
Two-carbon linked artemisinin-derived trioxane dimers
Two-carbon linked artemisinin-derived trioxane dimers and methods of their use for treating subjects infected with malaria or other parasitic infectious...
Synthesis of isohexide dicarbamates and derivatives thereof
Dicarbamates of the reduction products of 2-hydroxymethyl-5-furfural (HMF) and a method of preparing the same are described. The method involves reacting a...
Melampomagnolide B derivatives
The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, thiocarbamates, ester and amide derivatives of MMB....
Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic
This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium...
Modulators of virus assembly as antiviral agents
In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle...
Phosphoinositide 3-kinase inhibitor compounds and methods of use
Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R.sup.3 is a monocyclic heteroaryl group, and including stereoisomers, geometric...
Process for preparing oxymorphone, naltrexone, and buprenorphine
Methods are provided which include converting oripavine to other opiates, including converting oripavine to naltrexone, buprenorphine, 14-hydroxymorphinone...
Compounds for treatment of pain
The invention is directed to novel compounds, formulations containing said compounds or pharmaceutically acceptable salts thereof which are suitable for...
Transient protection of normal cells during chemotherapy
This invention is in the area of improved compounds, compositions and methods of transiently protecting healthy cells, and in particular hematopoietic stem and...
Macrocyclic compounds as ALK, FAK and JAK2 inhibitors
The present invention provides compounds of Formula I ##STR00001## or a pharmaceutically acceptable salt forms thereof, wherein R1, R2, R3, R4, R5, A and X...
Compounds of formula (I), described herein, exhibit human neutrophil elastase inhibitory properties, and are useful for the treatment of diseases and conditions...
Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives useful as
inhibitors of phosphodiesterase I
Optionally substituted (5- or 7- amino)-3,4-dihydro-(optionally 4-oxo, 4-thioxo or 4-imino)- 1H-pyrrolo [3,4-d]pyrimidin-2(6H)-ones, Compounds of Formula I,...